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AFTER PURI EYES 2% PN

AFTER PURI EYES 2% PN

Puri

Skin Booster
  • Uses certified medical Grade polynucleotides (PN) with documented certificate of analysis (CoA).
  • Manufactured in sterilised facilities operating under Good Manufacturing Practice (GMP).
  • Produced within an ISO Certified quality management system as indicated by the manufacturer.
  • Listed by international distributors as a CE Marked PN under Eye skin booster.
  • Cold Chain handling recommended by some distributors to preserve bioactivity of PN ingredients.
Under-eye Polynucleotide Injectable Skin Booster

Description

AFTER PURI EYES 2% PN (AETERDERM PURI EYES) is an injectable under-eye skin booster based on medical-grade polynucleotides (PN) combined with hyaluronic acid for the delicate peri-orbital area. It is specifically formulated to improve wrinkles, dark circles, and loss of elasticity around the eyes by stimulating dermal cell proliferation, collagen and elastin synthesis, and promoting wound recovery. The PN, derived from salmon DNA, works as a regenerative biopolymer to enhance tissue repair and dermal density, while hyaluronic acid provides deep moisturising and skin-plumping effects. Clinical data presented by the manufacturer show significant improvements in dermal wound closure, skin tone, texture, and moisture after a treatment course. The product is supplied as a pre-filled syringe (approx. 1 ml) intended for professional mesotherapy-style injection using 32G 4 mm meso needles, typically in a series of 3–4 sessions spaced 2–3 weeks apart.

Bnefits

  • Targets the delicate under-eye area with a formulation optimised for thin, fragile skin.
  • Medical-grade polynucleotides (PN) stimulate fibroblast activity, collagen and elastin synthesis, improving firmness and elasticity.
  • Generates a lifting effect by increasing dermal density via dermal cell proliferation.
  • Hyaluronic acid component draws moisture deep into the skin, providing intensive hydration and plumping.
  • Improves fine lines, wrinkles and crepey skin around the eyes.
  • Helps reduce the appearance of dark circles and uneven skin tone by improving skin thickness and dermal quality.
  • Supports wound recovery and tissue repair following aesthetic procedures.
  • Clinically documented improvements in skin roughness, pore volume, pigmentation and texture after treatment.
  • Low pain and minimal downtime when injected correctly with fine mesotherapy needles.
  • Produced with certified medical-grade PN and in GMP- and ISO-compliant, sterilised facilities.

Indications

  • Periorbital (under-eye) fine lines and superficial wrinkles.
  • Loss of elasticity and firmness in the under-eye area.
  • Dull, tired or uneven under-eye skin tone and visible dark circles.
  • Thin, fragile skin around the eyes requiring dermal density and thickness improvement.
  • Post-procedural skin quality optimisation around the eyes, as part of a professional treatment plan.
  • General under-eye rejuvenation in adults, as assessed appropriate by a qualified practitioner.

Composition

  • Polynucleotide (PN) 2 mg (approximately 2 mg/ml) derived from salmon DNA (medical-grade).
  • Hyaluronic acid (HA) – concentration not explicitly stated, included for deep moisturising and skin-plumping effect.
  • Physiological buffer and excipients (water for injection, salts and stabilisers) as per manufacturer’s formulation.
  • Solution is sterile, pyrogen-free and intended for single use only.

Formulation

  • Injectable under-eye skin booster based on medical-grade polynucleotides (PN) with hyaluronic acid.
  • Transparent or slightly opalescent sterile solution in a pre-filled syringe, suitable for intradermal/mesotherapy use.
  • Optimised viscosity for delivery through 32G 4.0 mm mesotherapy needles around the periorbital region.
  • Biocompatible, non-immunogenic PN polymer designed to stimulate regeneration rather than act as a bulk filler.

Packaging

  • Box containing one pre-filled syringe (approximately 1 ml) of AFTER PURI EYES 2% PN.
  • Syringe supplied sterile with Luer-lock fitting; single-use only.
  • Outer carton printed with AETERDERM PURI EYES branding, batch number, lot code and expiry date.
  • Intended for professional use in medical and aesthetic clinics; may be sold as part of clinical starter or treatment packs by distributors.

Usage

  • For professional use only; must be administered by suitably trained and licensed healthcare or aesthetic practitioners familiar with under-eye injection anatomy and complication management.
  • Conduct a full medical history and examination to confirm indication and rule out contraindications; obtain informed consent in line with local regulations.
  • Cleanse the face thoroughly and disinfect the under-eye treatment area with appropriate antiseptic solution.
  • Recommended needle: 32G 4.0 mm mesotherapy needles as per the manufacturer’s usage guide.
  • Recommended injection plane: primarily intradermal or very superficial subcutaneous injections in the periorbital area, avoiding vascular structures.
  • Injection detail from the manufacturer’s guide: approximately 0.02–0.035 cc per injection point, placed as small papules at 6–8 mm intervals, with around 15–30 injection points per eye region (to be adjusted according to the patient’s anatomy and practitioner’s protocol).
  • Inject slowly with low pressure, aspirating and observing standard precautions to avoid intravascular injection.
  • After injection, gently massage the treated area to help distribute the product and minimise unevenness, while avoiding excessive pressure.
  • Typical treatment cycle recommended: 3–4 sessions at intervals of about 2–3 weeks, followed by maintenance treatments as clinically indicated.
  • Post-treatment care usually includes avoiding make-up over injected areas for several hours, avoiding intense heat, saunas, sun exposure, or vigorous exercise for 24 hours, and following any additional instructions given by the clinic.
  • Do not reuse leftover product; discard all used syringes and needles immediately in appropriate sharps containers.

Contraindications

  • Known hypersensitivity or allergy to polynucleotides (including fish or salmon-derived products), hyaluronic acid, or any excipient in the formulation.
  • History of severe allergic reactions or anaphylaxis to injectable aesthetic products.
  • Active local infection, inflammation, dermatitis, eczema or other skin disease at or near the proposed injection sites.
  • Systemic infection, poorly controlled systemic illness, or immunocompromised status where elective injectables pose increased risk, unless specifically assessed and cleared by an appropriate specialist.
  • Bleeding disorders, significant coagulopathy, or use of anticoagulant/antiplatelet therapy where the risk of bleeding or haematoma cannot be adequately controlled.
  • Pregnancy or breastfeeding, due to limited safety data for PN-based injectables in these populations.
  • Patients under 18 years of age or younger than the legally permitted minimum for aesthetic procedures in the relevant jurisdiction.
  • Previous adverse reaction to polynucleotide or PN-based products.
  • Intravascular injection is strictly contraindicated; extreme caution is required in high-risk vascular areas.
  • Use with caution or avoid in patients with unrealistic expectations or body dysmorphic concerns until appropriately managed.

Adverse Effects

  • Common, usually transient injection-site reactions such as redness, tenderness, swelling, and bruising around the eye area.
  • Small papules, nodules or unevenness at injection points, typically resolving as the product disperses over several days.
  • Mild pruritus, warmth or discomfort in the treated area shortly after injection.
  • Haematoma or ecchymosis, particularly in the highly vascular periorbital region.
  • Infection at the injection site if aseptic technique or aftercare are inadequate.
  • Allergic or hypersensitivity reactions to PN (fish-derived) or other components, which may rarely be severe.
  • Very rare but serious complications related to vascular compromise (including skin necrosis or visual disturbance) if product is inadvertently injected into or compresses a blood vessel; these require urgent specialist management.
  • Any prolonged, worsening or unusual symptoms should prompt immediate clinical review and appropriate intervention.

Storage Conditions

  • Store in a cool, dry place within the temperature range specified by the manufacturer (commonly 2–25 °C), avoiding freezing.
  • Protect from direct sunlight and excessive heat to maintain product stability.
  • Keep the syringe in its original packaging until use to preserve sterility and protect from physical damage.
  • Do not use the product after the expiry date printed on the carton and syringe.
  • Do not use if packaging, blister, or syringe is damaged, has been opened previously, or shows signs of contamination.
  • Store out of reach of children and unauthorised persons.

Duration

Manufacturer treatment protocol recommends 3\u20134 sessions spaced 2\u20133 weeks apart. Clinical improvements in skin texture, tone and elasticity can persist for several months after a full course, with maintenance sessions scheduled according to individual response and practitioner discretion (commonly every 6\u201312 months).

Onset

Hydration and subtle smoothing may be noticeable shortly after treatment, while more pronounced improvements in wrinkles, skin tone, and dermal density develop progressively over several weeks as polynucleotides stimulate fibroblast activity and tissue remodelling.

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