Ameela Rejuvenation
Ameela Rejuvenation
Injectable Skin BoosterPolynucleotide-based biostimulatory gel for face, neck, hands and scalp
Certifications
- CE Marked polynucleotide injectable product for aesthetic use in applicable European/UK markets
- Manufactured under ISO 13485 Compliant medical device quality management systems (as part of the Ameela polynucleotide range)
- Produced using highly purified wild salmon DNA sourced through a traceable, regulated agri Food supply chain
- Formulated and marketed for professional use only in accordance with regional medical device and aesthetic practice regulations
- CE Marked polynucleotide injectable product for aesthetic use in applicable European/UK markets
- Manufactured under ISO 13485 Compliant medical device quality management systems (as part of the Ameela polynucleotide range)
- Produced using highly purified wild salmon DNA sourced through a traceable, regulated agri Food supply chain
- Formulated and marketed for professional use only in accordance with regional medical device and aesthetic practice regulations
Polynucleotide-based biostimulatory gel for face, neck, hands and scalp
Description
Ameela Rejuvenation is an advanced injectable biostimulatory treatment based on polymerised polynucleotides derived from highly purified wild salmon DNA. Formulated as a viscoelastic, sterile polynucleotide gel, it is designed to enhance skin tone, elasticity and texture across the face, neck, décolleté, hands and scalp, as well as to improve hair and scalp quality. By deeply hydrating tissues, supporting fibroblast activity and defending against oxidative stress, Ameela Rejuvenation helps smooth fine lines and wrinkles, improve firmness and radiance, and revitalise dull or lax skin without adding filler-like volume.
Bnefits
- Visibly improves skin tone, firmness and elasticity on the face, neck, décolleté, hands and scalp
- Softens the appearance of fine lines, wrinkles and hollowing in delicate areas (e.g. tear troughs)
- Deeply hydrates and revitalises dull or dehydrated skin
- Provides antioxidant protection against the visible effects of environmental and oxidative stress
- Supports tissue regeneration, helping to restore skin structure and density over time
- Helps condition the scalp and improve the appearance of hair thickness and quality
- Non-volumising biostimulant that maintains natural facial contours and expressions
- Suitable as a stand-alone regenerative skin booster or combined with other aesthetic treatments
- Clinically associated with measurable wrinkle reduction after a short treatment course
- Long-lasting results with simple maintenance schedule (typically one treatment every 6–9 months)
Indications
- Fine lines and wrinkles on the face and neck
- Skin laxity and loss of firmness or elasticity
- Dull, dehydrated or uneven skin appearance
- Loss of contour and early sagging, including mid-face and jawline support when using Rejuvenation protocols
- Deep tear troughs and periocular hollowing (under specialist protocols)
- Visible ageing and texture changes in the neck and décolleté
- Ageing or sun-damaged skin on the hands
- Scalp and hair concerns such as reduced hair quality or thinning (as part of hair/scalp protocols)
- General bio-stimulation and structural skin improvement in multiple areas
Composition
- Polymerised polynucleotide (PDRN) gel 2% (polynucleotide gel 20 mg/ml) in a 2 ml pre-filled syringe (total 40 mg polynucleotides)
- Polynucleotides of animal origin derived from highly purified wild salmon DNA
- Molecular weight of polynucleotides: at least 1000 KDa
- pH between 6.8 and 7.5
- Viscosity: approximately 28–43 Pa·s (measured pre-sterilisation)
- Sterile, pyrogen-free, viscoelastic injectable gel in physiological buffer
- Free from protein impurities that could trigger significant immune reactions (highly purified DNA fragments)
Formulation
- Viscoelastic, sterile, non-pyrogenic polynucleotide gel (PDRN) for injectable use
- Polymerised polynucleotide formulation engineered for multi-area rejuvenation (face, neck, décolleté, hands and scalp)
- Biocompatible and biodegradable gel that is gradually resorbed while stimulating tissue repair
- Non-crosslinked, non-volumising structure designed for hydration, bio-stimulation and structural support rather than filling
- Formulated from wild salmon DNA with high biological integrity and traceable sourcing
Packaging
- Single pre-filled 2 ml syringe of Ameela Rejuvenation polynucleotide gel
- Syringe supplied in a branded Ameela Rejuvenation carton with protective blister or tray
- Outer and inner packaging labelled with product name, volume (2 ml), concentration (20 mg/ml), lot number, expiry date, storage conditions and regulatory symbols
- Intended for single-patient, single-use only; any unused product must be discarded after the procedure
Usage
- Ameela Rejuvenation is for professional medical aesthetic use only and must be administered by suitably trained healthcare practitioners experienced in injectable treatments.
- Obtain a full medical history, assess indications and suitability for polynucleotide treatment, and secure informed consent prior to injection.
- Cleanse and disinfect the treatment area thoroughly using an appropriate antiseptic, taking care to avoid mucosal surfaces and eyes.
- Topical anaesthetic may be applied according to clinic protocol and manufacturer guidance, then completely removed before injection.
- Using a suitable fine needle or cannula, inject small amounts of the gel into the appropriate dermal or subdermal planes in the selected areas (face, neck, décolleté, hands or scalp), following recommended techniques such as micro-depot, linear threading or fanning.
- Avoid intravascular injection and take particular care in anatomical danger zones; aspirate in line with clinic policy and apply precise, low-pressure injection technique.
- Distribute product evenly across the treatment zone; gently mould if needed to reduce any palpable irregularities while avoiding excessive pressure.
- A standard treatment protocol typically consists of 2–3 sessions spaced approximately 2–3 weeks apart, with adjustments based on individual skin condition and practitioner judgement.
- Advise patients that maintenance sessions are often recommended every 6–9 months to sustain results.
- Provide post-treatment guidance including avoiding makeup on treated areas for the recommended period, refraining from intense exercise, heat exposure (sauna, sunbeds) and alcohol for 24–48 hours, and not massaging or manipulating treated areas unless instructed.
- Monitor for early adverse reactions; instruct patients to report any persistent pain, marked swelling, unusual discolouration or other concerning symptoms immediately.
- Dispose of all used syringes, needles and other sharps in approved sharps containers and handle clinical waste according to local regulations.
- Do not reuse the syringe or any residual product; Ameela Rejuvenation is strictly single-use.
Contraindications
- Known hypersensitivity or allergy to polynucleotides, salmon-derived products or any component of the formulation
- Active skin infections, inflammation, dermatitis or herpetic lesions at or near the proposed injection sites
- Severe chronic inflammatory or autoimmune conditions affecting the treatment area without appropriate specialist assessment
- History of severe anaphylactic reactions or multiple serious allergies (relative contraindication requiring careful risk–benefit assessment)
- Pregnancy and breastfeeding due to insufficient safety data
- Uncontrolled bleeding or coagulation disorders, or concurrent anticoagulant/antiplatelet therapy without medical evaluation (relative contraindication)
- Recent aggressive procedures (e.g. deep chemical peels, ablative lasers, surgery) in the same area without adequate healing interval
- Any systemic illness or local condition that, in the practitioner’s clinical judgement, makes injectable polynucleotide treatment unsafe or inappropriate
Adverse Effects
- Expected transient injection-site reactions including redness, swelling, tenderness, warmth or mild pain
- Local bruising or haematoma formation at injection points, particularly in vascular areas such as the periocular region or neck
- Temporary palpable nodules, papules or unevenness that generally resolve as oedema subsides or with appropriate practitioner management
- Short-term itching, tightness or heightened sensitivity in treated areas
- Occasional more pronounced or prolonged swelling or inflammatory response, especially in predisposed individuals
- Low risk of infection, abscess or granulomatous reaction if aseptic technique is not strictly followed or in susceptible patients
- Very rare risk of intravascular injection or vascular compromise, as with any injectable treatment; practitioners must be familiar with recognition and emergency management of such events
- Any persistent, severe or unusual adverse effect should prompt immediate medical review and be managed according to local clinical and device-vigilance protocols
Storage Conditions
- Store in a clean, dry environment at the temperature range specified in the official product leaflet (commonly within 2 °C to 25 °C).
- Protect from direct sunlight and sources of heat or freezing temperatures.
- Do not freeze; freezing may alter the polynucleotide gel structure and compromise efficacy and safety.
- Keep the pre-filled syringe in its original carton and blister until use to maintain sterility and protect from light.
- Do not use after the expiry date printed on the packaging or if the packaging, blister or syringe appears damaged or compromised.
Duration
Usual protocols involve 2\u20133 treatment sessions spaced about 2\u20133 weeks apart, with results commonly lasting around 6\u20139 months. Maintenance is typically 1 treatment every 6\u20139 months, tailored to patient age, lifestyle and skin condition.
Onset
Patients may notice initial improvements in hydration and radiance within the first few weeks, with progressive benefits in tone, elasticity and wrinkle reduction developing over subsequent weeks and becoming more pronounced after completion of the 2\u20133 session course.
