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Ami Plus

Ami Plus

Ami Plus X

Skin Boosters
  • Manufactured in GMP Certified facilities in South Korea (as stated in trade and manufacturer information)
  • Professional Use injectable polynucleotide (PN) skin booster marketed for medical aesthetic practitioners
  • Compliance with relevant Korean cosmetic/medical manufacturing standards; practitioners must verify local regulatory status (e.g. CE/MHRA) in their own jurisdiction before use
Polynucleotide (PN) injectable skin booster

Description

Ami Plus X is a next-generation polynucleotide (PN) injectable skin booster formulated with 2% highly purified polynucleotides (PN 20 mg/ml; 40 mg total in 2 ml) derived from salmon DNA. Designed for full-face, neck, décolletage and hand rejuvenation, it works at a cellular level to stimulate the skin’s own repair mechanisms, intensify hydration, and support collagen and elastin synthesis. This biostimulatory treatment improves skin density, firmness and bounce, helps refine pores and smooth superficial wrinkles, and promotes a more even, radiant complexion without adding heavy, filler-like volume.

Bnefits

  • Stimulates the skin’s natural repair mechanisms for deep regeneration and revitalisation
  • Supports collagen and elastin production, improving skin firmness, bounce and tone
  • Enhances moisture retention for a plumper, more supple and hydrated skin feel
  • Helps smooth the appearance of superficial lines, fine wrinkles and mild folds
  • Refines skin texture and contributes to a more even, luminous complexion
  • Strengthens the skin barrier and improves overall skin health and resilience
  • Provides antioxidant support, helping to defend against environmental and oxidative stress
  • Offers non-volumising, natural-looking rejuvenation suitable for a wide range of ages and skin types

Indications

  • Global skin revitalisation and rejuvenation of the face, neck, décolletage and hands
  • Dull, dehydrated or tired-looking skin needing improved hydration and radiance
  • Loss of skin firmness, elasticity and density due to ageing or environmental damage
  • Superficial wrinkles and fine lines, including early signs of photoageing
  • Uneven skin tone and texture, enlarged pores and roughness
  • Supportive treatment after other aesthetic procedures where deep regeneration is desired (according to practitioner protocol)
  • Patients seeking a regenerative, non-filler injectable to improve overall skin quality

Composition

  • Polynucleotides (PN) 2% – 20 mg/ml (total 40 mg PN in 2 ml)
  • Highly purified polynucleotides (PN / PDRN) derived from salmon DNA
  • Sterile, pyrogen-free aqueous gel in physiological buffer suitable for intradermal injection
  • Clear/transparent liquid formulation designed for skin booster applications

Formulation

  • High-concentration 2% PN (20 mg/ml) polynucleotide injectable skin booster
  • Biocompatible, DNA-derived polymer fragments that support dermal matrix regeneration
  • Non-crosslinked, non-volumising biostimulatory formulation focused on repair and hydration rather than bulk filling
  • Viscosity suitable for dermal/mesotherapy injection using fine-gauge needles
  • Developed and manufactured in South Korea in GMP-certified facilities

Packaging

  • 1 pre-filled syringe × 2 ml Ami Plus X PN 2% per box
  • Each syringe contains 40 mg of polynucleotides (PN) at 20 mg/ml concentration
  • Single-use, sterile packaging intended for professional injectable use only
  • Outer carton and inner blister labelled with product name, volume, lot number, expiry date and origin (South Korea)

Usage

  • Ami Plus X is for professional use only and must be administered by trained medical or aesthetic practitioners.
  • Before treatment, take a full medical history, assess indications and contraindications, and obtain informed consent.
  • Cleanse and disinfect the treatment area (face, neck, décolletage, hands) using appropriate antiseptic measures.
  • If needed, apply topical anaesthetic according to clinic protocol and remove it completely before injection.
  • Inject into the dermis or superficial subdermal plane using a fine needle (commonly 30G–32G) or appropriate mesotherapy device.
  • Typical treatment areas include the face, neck, décolletage and hands; adjust injection patterns and depth to skin thickness in each area.
  • According to manufacturer guidance, approximately 2 ml is sufficient for both cheeks and neck; 4 ml can be used for full-face treatment when using more than one syringe in a session.
  • Recommended injection volume per point is roughly 0.05–0.1 ml for thinner skin and 0.1–0.2 ml for thicker skin, distributed across multiple points.
  • Employ micro-bolus, linear threading, fanning or mesotherapy nappage techniques depending on clinical judgement, while carefully avoiding intravascular injection.
  • Standard protocols generally recommend a series of 2–4 treatment sessions spaced about 2–4 weeks apart, depending on skin condition and desired outcome.
  • After injection, gently smooth the treated area if necessary to optimise distribution, avoiding excessive pressure.
  • Advise patients to avoid sun exposure, alcohol, hot showers, saunas and vigorous exercise for several days post-treatment (often 3–7 days) and to use sunscreen as directed.
  • Dispose of all used needles, syringes and consumables in approved sharps and clinical waste containers; do not reuse any remaining product.

Contraindications

  • Known hypersensitivity or allergy to polynucleotides, salmon-derived ingredients or any component of the formulation
  • Active skin infections, inflammatory skin diseases or lesions (e.g. dermatitis, herpes) at or near the intended injection sites
  • Severe autoimmune or connective tissue disorders affecting the skin, unless carefully evaluated by a specialist
  • History of severe anaphylactic reactions or multiple serious allergies (relative contraindication requiring cautious risk assessment)
  • Pregnancy and breastfeeding, due to lack of sufficient safety data for injectable polynucleotide treatments
  • Uncontrolled coagulation disorders or current use of systemic anticoagulant/antiplatelet therapy without appropriate medical assessment (relative contraindication)
  • Recent aggressive cosmetic procedures (e.g. deep chemical peels, ablative laser, surgery) in the treatment area without adequate healing time
  • Any other systemic disease or local condition that, in the practitioner’s judgement, makes injectable skin booster treatment unsuitable

Adverse Effects

  • Transient redness, swelling, tenderness or mild pain at injection sites
  • Small bruises or haematomas, especially in vascular areas such as around the eyes or on the neck and décolletage
  • Temporary papules, bumps or slight unevenness at injection points that usually resolve as oedema settles
  • Mild itching, tightness or sensitivity in the treated region during the early post-treatment period
  • Occasional more prolonged swelling or inflammatory response in sensitive individuals
  • Low risk of infection, abscess or granulomatous reaction if aseptic technique is not rigorously followed or in susceptible patients
  • Very rare risk of intravascular injection or vascular compromise, as with any injectable; requires prompt recognition and management by trained professionals
  • Any persistent, worsening or unusual adverse effect should be promptly evaluated and managed according to local clinical and regulatory guidelines

Storage Conditions

  • Store between approximately 1–25°C in a cool, dry, dark place away from direct sunlight.
  • Do not freeze, as freezing may damage the polynucleotide structure and compromise safety and efficacy.
  • Keep the syringe in its original blister and carton until immediately before use to maintain sterility and protect from light.
  • Single-use only: do not reuse any remaining product after opening; discard according to clinical waste regulations.
  • Respect the expiry date printed on the packaging and do not use if the packaging or syringe is damaged or compromised.

Duration

Common protocols recommend a course of 2\u20134 sessions spaced approximately 2\u20134 weeks apart, with results typically lasting several months; maintenance treatments can be scheduled according to individual skin response and practitioner guidance.

Onset

Initial improvements in hydration, glow and skin softness are often observed after the first session, with more noticeable changes in firmness, texture and fine lines developing progressively over the following weeks and consolidating after completion of the treatment course.

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