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Croma PhilArt Next (1 x 2 ml)

Croma PhilArt Next (1 x 2 ml)

PhilArt (by Croma-Pharma)

Medical device – injectable skin booster / biostimulator
  • CE Marked medical device (PhilArt / PolyPhil Next) for intradermal use in aesthetic medicine.
  • Manufactured by Croma Pharma GmbH under ISO 13485 Compliant quality management for medical devices.
  • Based on PN HPT (Polynucleotide High Purification Technology), ensuring a high Purity, highly biocompatible polynucleotide ingredient.
  • Compliant with current European medical device regulations applicable to CE Marked injectable biostimulators.
Intradermal polynucleotide and hyaluronic acid gel for skin rejuvenation

Description

Croma PhilArt Next is an advanced CE-marked injectable skin booster containing a synergistic combination of highly purified polynucleotides (PN) and non-crosslinked hyaluronic acid for intradermal use. Supplied as a sterile, apyrogenic, single-use gel in a 1 x 2 ml pre-filled syringe (PN-HPT 20 mg/2 ml and HA 20 mg/2 ml), it is designed for mature, dehydrated and photo-aged skin presenting with medium to deep wrinkles, loss of elasticity, scars and stretch marks. By deeply hydrating the skin, stimulating fibroblasts and supporting collagen and elastin synthesis, PhilArt Next improves skin texture, firmness, tone and radiance on the face, neck, décolletage, hands and scarred areas.

Bnefits

  • Deep skin rehydration: delivers long-lasting hydration to combat dryness and improve skin texture.
  • Skin rejuvenation and biostimulation: stimulates fibroblast activity, promoting collagen and elastin synthesis for firmer, more elastic skin.
  • Wrinkle correction: targets medium to deep wrinkles, smoothing lines and improving overall skin quality.
  • Scar and stretch-mark remodeling: supports regeneration of tissue in areas with scars, acne scars and stretch marks.
  • PN-HPT technology: uses highly purified long-chain polynucleotides derived from fish DNA, with a proven safety and tolerability profile and strong antioxidant action.
  • Dual-action formula: combination of polynucleotides (10 mg/ml) and non-crosslinked hyaluronic acid (10 mg/ml) for synergistic hydration, viscoelastic support and tissue repair.
  • Versatile treatment areas: suitable for face, neck, décolletage and hands, as well as localized scarred or photo-aged skin.
  • CE-marked medical device manufactured under ISO 13485 quality standards, ensuring consistent purity and safety.
  • Natural-looking results: improves tone, texture and radiance without excessive volumisation, preserving a healthy, luminous glow.

Indications

  • Mature and dehydrated skin showing signs of ageing.
  • Medium to deep facial wrinkles and folds.
  • Loss of skin elasticity, firmness and tone.
  • Photo-damaged skin with dullness and rough texture.
  • Scars and acne scars (facial and body).
  • Stretch marks.
  • Skin quality improvement on face, neck, décolletage and hands.
  • Adjunct to other aesthetic procedures (e.g. PRP, fillers, peels) as part of a comprehensive rejuvenation plan, as decided by a qualified practitioner.

Composition

  • Polynucleotides (PN-HPT) 20 mg/2 ml (10 mg/ml) – highly purified long-chain polynucleotides derived from fish DNA.
  • Non-crosslinked hyaluronic acid 20 mg/2 ml (10 mg/ml).
  • Mannitol – slows hyaluronic acid degradation and provides antioxidant support (as stated in technical fact sheet).
  • Buffering and stabilising excipients in a sterile, apyrogenic gel vehicle suitable for intradermal administration.

Formulation

  • Sterile, apyrogenic, visco-surgical gel for intradermal injection.
  • Single-use, pre-filled 2 ml syringe containing a combination of polynucleotides (10 mg/ml) and non-crosslinked hyaluronic acid (10 mg/ml).
  • Medical device based on PN-HPT (Polynucleotide High Purification Technology) for high purity and reduced risk of contaminants.
  • No lidocaine / local anaesthetic in the formulation.
  • Designed exclusively for professional medical use.

Packaging

  • Box containing 1 x 2 ml pre-filled glass syringe of PhilArt Next.
  • Includes 2 x 30G ½" (13 mm) sterile needles for intradermal injection.
  • Each syringe is batch-coded for full traceability.

Usage

  • For professional use only: must be administered by suitably qualified healthcare professionals trained in intradermal injection techniques and the use of polynucleotide-based biostimulators.
  • Injection depth: intradermal, typically using microdroplet, linear retrograde or fan techniques according to the treatment area and clinical judgement.
  • Treatment areas: face (including mid-face), neck, décolletage, hands and selected areas with scars or stretch marks.
  • Recommended protocol: usually 3 to 4 treatment sessions spaced approximately 14–21 days apart, depending on skin condition and practitioner assessment.
  • Maintenance: follow-up sessions may be scheduled approximately every 4–6 months (or 6–9 months in some protocols) to maintain results, tailored to the individual patient.
  • Before treatment: perform full medical history, clinical examination and obtain informed consent; disinfect the treatment area according to local clinical protocols.
  • After treatment: advise patients about possible temporary injection-site reactions (redness, swelling, bruising, tenderness or small bumps) and provide appropriate aftercare instructions; avoid make-up, intense heat exposure (sauna, sunbeds) and vigorous exercise for a short period after treatment as advised by the practitioner.

Contraindications

  • Known hypersensitivity or allergy to any component of the product, including polynucleotides of fish origin or hyaluronic acid.
  • History of severe allergies or anaphylactic reactions.
  • Active skin infections, inflammatory skin disease or lesions at the proposed injection sites.
  • Known coagulation disorders or current use of anticoagulant or antiplatelet therapy where intradermal injections are deemed unsafe by the treating physician.
  • Autoimmune diseases or uncontrolled systemic disease, unless the treating specialist considers the procedure safe and appropriate.
  • Current or recent local or systemic infection, fever or general illness.
  • Pregnancy and breastfeeding (treatment generally not recommended due to lack of safety data in these populations).
  • Known tendency to form keloids or hypertrophic scars in the planned treatment area.
  • Any other condition that, in the judgement of the treating healthcare professional, would contraindicate intradermal aesthetic injections.

Adverse Effects

  • Common, usually transient injection-site reactions: redness, swelling, tenderness, bruising and small palpable bumps at the treatment points, typically resolving within a few days.
  • Temporary itching, warmth or mild discomfort in the treated areas.
  • Rare: infection, prolonged inflammation, nodules or hypersensitivity reactions; immediate medical evaluation is required if such events occur.
  • Very rare: allergic reactions including those related to fish-derived polynucleotides; immediate medical attention is required if signs of severe allergy or anaphylaxis appear.

Storage Conditions

  • Store according to the manufacturer’s instructions (typically at controlled room temperature, protected from extreme heat and direct sunlight).
  • Do not freeze.
  • Keep the syringe in its original packaging until use to maintain sterility and protect from light.
  • Do not use after the expiry date printed on the pack.
  • Keep out of the sight and reach of children.
  • Single-use only: any unused product must be discarded after the procedure according to local regulations for medical waste.

Duration

A typical initial course consists of 3\u20134 sessions at 2\u20133 week intervals. Results in skin hydration, elasticity and texture usually last around 6\u20139 months (up to approximately 6\u201312 months in some sources), after which maintenance treatments are recommended according to individual response.

Onset

Initial improvement in hydration and skin radiance may be visible within days to weeks after the first sessions, with progressive enhancement of firmness, elasticity and wrinkle reduction over the full treatment course as collagen and elastin synthesis are stimulated.

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