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Exosomes ASCE (20mg+5ml)

Exosomes ASCE (20mg+5ml)

ASCE+

Exosome skin booster
  • Classified and marketed as a professional topical/mesotherapy exosome Based skin booster rather than as a medicinal product or dermal filler.
  • Manufactured by ExoCoBio using proprietary ExoSCRT exosome isolation and purification technology under cosmetic and aesthetic product quality systems.
  • Listed in independent scientific reviews as a commercial exosome product for topical skin rejuvenation, stored at 2–8°C, derived from Rosa damascena stem cells.
  • ExoCoBio reports cosmetic registrations with regulatory authorities in multiple territories (e.g., Korea, US, EU) for ASCE+ products, though local status may vary by market and indication.
  • Practitioners should verify and comply with local regulations and professional guidelines regarding the use of exosome Containing cosmetic and mesotherapy products.
Lyophilised exosome derma signal kit for skin rejuvenation

Description

Exosomes ASCE+ SRLV (20mg+5ml) is a professional exosome-based skin booster developed by ExoCoBio as part of the ASCE+ Derma Signal line. Each kit contains 5 billion purified, lyophilised exosomes derived from Rosa damascena (Damask rose) stem cells using the patented ExoSCRT technology, combined with a hyaluronic-acid-based activator. The formulation delivers nano-sized extracellular vesicles, growth factors, peptides, amino acids, coenzymes, vitamins, minerals, glutathione, retinol and other actives to support skin regeneration, repair and anti-inflammatory action. Designed primarily for use with mesotherapy, microneedling or other in-clinic procedures on intact skin, ASCE+ SRLV targets fine lines, wrinkles, enlarged pores, pigmentation, redness, acne scarring and overall loss of elasticity and radiance, providing a comprehensive regenerative and anti-ageing solution.

Bnefits

  • Provides approximately 5 billion standardized exosomes per vial, supporting intensive skin regeneration at a cellular level.
  • Delivers 96 types of miRNAs and over 200 proteins that orchestrate anti-inflammatory, anti-ageing and skin-brightening effects.
  • Hydrates deeply through hyaluronic acid, improving moisture balance and skin plumpness.
  • Helps visibly reduce fine lines, wrinkles and age-related loss of firmness by stimulating collagen and elastin synthesis.
  • Improves overall skin tone and radiance while helping to reduce hyperpigmentation and uneven coloration.
  • Softens acne scars, refines enlarged pores and smooths rough or coarse texture.
  • Calms redness, irritation and inflammatory skin conditions, including atopic dermatitis and rosacea, when used under professional supervision.
  • Strengthens and reconstructs the skin barrier by improving the dermis and subcutaneous tissue environment.
  • Accelerates post-procedure recovery, reduces downtime and supports wound-healing processes when used after treatments such as lasers, RF microneedling and other energy-based or needling procedures on intact skin.
  • Offers plant-derived, acellular exosomes that avoid direct use of human cells while still providing potent regenerative signalling.

Indications

  • Skin rejuvenation and anti-ageing for the face, neck and décolletage.
  • Enlarged pores and redness in combination with texture irregularities.
  • Rough, dry or dull skin lacking vitality and glow.
  • Loss of elasticity and firmness, flaccid or sagging skin.
  • Acne-prone skin with residual acne scars and uneven texture.
  • Skin with reduced regenerative capacity or impaired barrier function.
  • Sensitive, thin skin prone to irritation from environmental or procedural stress.
  • Inflammatory dermatoses such as atopic dermatitis and rosacea, when used as part of a medically supervised aesthetic protocol.
  • Hyperpigmentation and age spots requiring brightening and reduction of melanin content.
  • Adjunctive care after aesthetic procedures (e.g., microneedling, RF microneedling, laser treatments, peels) on intact skin to improve recovery and outcomes.

Composition

  • Two-vial system per kit:
  • Vial 1 – Lyophilised Exosome Powder (20mg):
  • • Rosa Damascena Callus Extracellular Vesicles (rose stem-cell-derived exosomes) – central active component delivering nano-sized vesicles rich in growth factors, cytokines and signalling molecules.
  • • 5 growth factors – recombinant sh-oligopeptides and sh-polypeptides that stimulate cell proliferation, collagen synthesis and tissue repair.
  • • 6 peptides – including signalling and biomimetic peptides (e.g., Acetyl Hexapeptide-8, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Copper Tripeptide-1 and related complexes) that target wrinkles, firmness and matrix renewal.
  • • 19 amino acids – such as alanine, arginine, aspartic acid, glutamic acid, glycine, histidine, lysine, ornithine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine and others that support protein synthesis and tissue regeneration.
  • • 4 coenzymes – including nicotinamide adenine dinucleotide (NAD+), thiamine diphosphate, flavin adenine dinucleotide and coenzyme A to enhance cellular metabolism and repair.
  • • Vitamins – such as ascorbic acid (vitamin C) and retinol (vitamin A) to provide antioxidant, brightening and anti-wrinkle effects.
  • • Minerals – including magnesium, potassium and other trace elements for cellular balance and enzyme function.
  • • Glutathione – a potent antioxidant and depigmenting molecule that reduces oxidative stress and melanin synthesis.
  • • Stabilising excipients (e.g., trehalose, mannitol and buffers) to protect exosomes and active molecules during lyophilisation.
  • Vial 2 – Activator Solution (5ml):
  • • Hyaluronic Acid (HA) – hydrating base that improves moisture, volume and diffusion of exosomes and actives.
  • • 4 additional growth factors – supporting cell renewal and dermal remodelling.
  • • Amino acids – extra building blocks for collagen and structural proteins.
  • • Minerals and electrolytes – to support skin homeostasis.
  • Global active profile:
  • • 5 billion standardized exosome particles per kit.
  • • 96 types of miRNAs and more than 200 proteins characterized by anti-inflammatory, anti-ageing, brightening and regenerative properties.

Formulation

  • Professional lyophilised exosome-based derma signal kit for topical/mesotherapeutic use on intact skin.
  • Consists of a 20mg vial of freeze-dried exosomes and a 5ml hyaluronic-acid-based activator solution.
  • Exosomes derived from Rosa damascena stem cells and purified using ExoCoBio’s ExoSCRT technology for high purity and standardized potency.
  • Acellular formulation: exosomes and bioactive molecules only, without intact cells or DNA.
  • Designed to be used immediately after reconstitution to maximize biological activity.
  • Intended as an in-clinic cosmeceutical / skin booster, often combined with microneedling, RF microneedling, lasers or other non-ablative aesthetic procedures.

Packaging

  • Single-patient professional kit.
  • Pack contents:
  • • 1 x 20mg vial containing lyophilised exosome powder (SRLV-1).
  • • 1 x 5ml vial containing activator/diluent solution (SRLV-2).
  • Kit is intended for one full treatment session for one patient.
  • Outer carton branded as ASCE+ Derma Signal Kit SRLV, indicating lyophilised powder for skin care and exosome-based technology.
  • Each vial is sealed and labelled with lot number and expiry date for traceability.

Usage

  • For professional in-clinic use only by licensed practitioners (doctors, nurses or trained medical aestheticians) in accordance with local regulations.
  • Reconstitution:
  • 1. Insert the full contents of the 5ml activator vial into the 20mg lyophilised powder vial (or vice versa depending on clinic workflow) under aseptic conditions.
  • 2. Gently swirl or roll the vial until the powder is fully dissolved; avoid vigorous shaking that may generate excessive bubbles.
  • 3. Allow the solution to stand for approximately 3–5 minutes to complete dissolution and allow bubbles to dissipate.
  • 4. Use the reconstituted solution within a maximum of 3 hours for optimal stability and safety; discard any unused remainder.
  • Application options (on intact skin):
  • • Mesotherapy: administer small intradermal or superficial papular injections to the face and neck (and other indicated areas) as per clinic protocol, avoiding intravascular injection.
  • • Microneedling / RF microneedling: apply the solution topically to the treatment area during or immediately after the procedure to enhance penetration through microchannels.
  • • Topical / nanosoft delivery: apply evenly across the skin surface and work in with nanoneedles or other transdermal delivery devices approved in the clinic.
  • Treatment protocol:
  • • Intensive course: typically 3–5 sessions, spaced about every 2–4 weeks, depending on the protocol used (some manufacturer protocols recommend 5 sessions, 1 every 2 weeks).
  • • Maintenance: an additional session is often recommended 6–12 months after a full course, or as clinically indicated, to maintain results.
  • • One kit (20mg + 5ml) is generally used per session and per patient.
  • Post-treatment care:
  • • Apply soothing, non-irritating post-procedure skincare and broad-spectrum sunscreen.
  • • Advise patients to avoid harsh products, excessive heat, sun exposure and additional procedures until the skin has fully recovered.
  • • Follow specific manufacturer and clinic guidelines for combination with lasers, peels and other energy-based treatments.

Contraindications

  • Known hypersensitivity or allergy to any component of the formulation, including Rosa damascena-derived materials, hyaluronic acid, peptides, amino acids, vitamins, minerals, glutathione, retinol or excipients.
  • Active skin infections (bacterial, viral or fungal) in the proposed treatment area.
  • Open wounds, non-epithelialised lesions or active ulcerations at the treatment site.
  • Severe or uncontrolled inflammatory dermatoses in the target area (e.g., severe atopic dermatitis, psoriasis flare) without specialist oversight.
  • History of severe anaphylactic reactions to injectable or mesotherapy products with similar excipients.
  • Autoimmune disease or significant immunosuppression where wound healing is compromised, unless cleared by a supervising physician.
  • Pregnancy and breastfeeding: although the product is plant-stem-cell-derived and topical/mesotherapeutic, robust safety data in these populations are limited; use should be avoided unless a medical professional judges that potential benefits outweigh risks.
  • Use in patients who are not appropriate candidates for mesotherapy or microneedling due to bleeding disorders, anticoagulation or other systemic risk factors.
  • Application by untrained personnel or outside an appropriate clinical environment.

Adverse Effects

  • Transient erythema, swelling, warmth or tenderness at the treatment sites, especially when combined with mesotherapy or microneedling procedures.
  • Mild bruising, pinpoint bleeding or oedema related to injection or needling techniques.
  • Short-term dryness, tightness or mild flaking as part of the regenerative process.
  • Potential temporary exacerbation of underlying skin sensitivity or redness, particularly in reactive or rosacea-prone individuals if not properly assessed.
  • Rare allergic or hypersensitivity reactions (e.g., persistent erythema, pruritus, burning, urticaria or angioedema) to one or more ingredients.
  • Very rare risk of infection, scarring or post-inflammatory hyperpigmentation, especially if aseptic technique is inadequate or overly aggressive procedures are combined.
  • Any unusually severe, persistent or worsening adverse effect should prompt immediate discontinuation and medical evaluation.

Storage Conditions

  • Store unopened vials in a refrigerator between 2°C and 8°C, as specified by product literature and independent reviews.
  • Keep vials in original packaging to protect from light and contamination until use.
  • Do not freeze unless explicitly stated by the manufacturer.
  • Use before the expiry date indicated on each vial and outer carton.
  • After reconstitution, use the mixture as soon as possible and within a maximum of approximately 3 hours; discard any remaining solution thereafter.
  • Keep out of reach of children and store away from sources of heat and direct sunlight.

Duration

Recommended initial course commonly consists of 3\u20135 treatment sessions, typically performed every 2\u20134 weeks (often every 2 weeks for intensive care or every 4 weeks in some protocols). Manufacturer training materials also describe a regimen of 5 sessions with maintenance sessions at 6\u201312 month intervals. The total duration of a full course therefore usually spans approximately 2\u20134 months, with long-term maintenance tailored to individual skin response and clinical judgement.

Onset

Subtle improvements in hydration, comfort and luminosity may be observed within a few days after treatment. More visible changes in texture, tone, pore size and fine lines typically become apparent over several weeks, with many protocols reporting clearly noticeable results after about 6\u20137 weeks and continued improvement over the full course of 3\u20135 sessions.

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