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Jalupro HMW

Jalupro HMW

Jalupro

Aesthetic medicine
  • Class III medical device with CE marking under applicable European medical device legislation (e.g. 93/42/EEC / MDR transition).
  • Manufactured by Professional Derma SA under an ISO 13485 Compliant medical device quality management system.
  • Sterile, single Use injectable dermal biorevitaliser intended exclusively for professional medical use.
  • Complies with relevant biocompatibility and safety standards for injectable hyaluronic acid Based dermal products.
Injectable skin booster / dermal biorevitaliser

Description

Jalupro HMW (High Molecular Weight) is a sterile, resorbable injectable dermal biorevitaliser combining high molecular weight, non-crosslinked sodium hyaluronate with a specific amino acid complex (glycine, L-proline, L-leucine, L-lysine HCl). It is designed to treat skin defects and depressions caused by wrinkles and scars, and to revitalise markedly photo-aged or chrono-aged, dry and dehydrated skin. By deeply hydrating the dermis and supplying fibroblasts with collagen-building amino acids, Jalupro HMW stimulates extracellular matrix regeneration, improves elasticity and tone, and softens deeper lines, furrows and atrophic scars. It is suitable for use on the face and multiple body areas and is particularly indicated for moderate to severe photo-ageing and for skin needing intensive hydration, including during summertime.

Bnefits

  • Acts as a dermal biorevitaliser in areas where the skin is very marked (deep wrinkles, furrows, pronounced depressions).
  • Deeply hydrates the dermis thanks to 2% high molecular weight hyaluronic acid (20 mg/ml), improving turgor and plumpness.
  • Stimulates fibroblasts via an amino acid complex (glycine, L-proline, L-leucine, L-lysine HCl) to promote new collagen synthesis and extracellular matrix regeneration.
  • Reduces the appearance of moderate to severe wrinkles and skin depressions caused by ageing or scars.
  • Improves tone, firmness and elasticity of thin, dehydrated and photo-damaged skin.
  • Helps improve the appearance of certain scars and fibrotic textures by remodelling dermal tissue.
  • Provides intense, long-lasting hydration, making it particularly suitable for dry or dehydrated skin and procedures during the summertime.
  • Can be used as a stand-alone biorevitalisation treatment or combined with other aesthetic procedures to enhance and prolong results.
  • Generally offers visible improvements lasting up to around 6 months, with good tolerability profile when used correctly.

Indications

  • Photo-ageing and chrono-ageing of the face and body (moderate and severe degree).
  • Dry and dehydrated skin requiring deep and prolonged hydration.
  • Skin defects and depressions caused by wrinkles and scars (including atrophic and some post-acne scars).
  • Marked furrows and deeper wrinkles where stronger biorevitalisation is required.
  • Preparation, improvement and prolongation of results for various aesthetic procedures (e.g. peels, lasers, dermabrasion, radiofrequency, dermal fillers, botulinum toxin).
  • Biorevitalisation of face, neck, décolleté, underarms, hands, inner thighs, abdomen and knee region.
  • Supportive treatment in skin that has been significantly photo-damaged (solar elastosis) where enhanced hydration and collagen stimulation are desired.

Composition

  • Sodium hyaluronate (high molecular weight) 20 mg/ml (2% solution) – total 20 mg in the 1.5 ml syringe.
  • Amino acid complex 80 mg in the 1 ml bottle, composed of approximately:
  • • Glycine
  • • L-Proline
  • • L-Lysine HCl
  • • L-Leucine
  • Water for injection (in sodium hyaluronate syringe).
  • Buffering and stabilising excipients as listed in the official instructions for use.

Formulation

  • Sterile, reabsorbable injectable solution for intradermal implantation.
  • Two-component system supplied as:
  • • One glass disposable prefilled syringe (1.5 ml) containing a sterile gel of high molecular weight sodium hyaluronate (20 mg).
  • • One glass bottle (1 ml) containing a sterile solution/lyophilised powder of amino acids (80 mg) – glycine, L-proline, L-leucine, L-lysine HCl.
  • Immediately before use, the sodium hyaluronate and amino acid solution are combined according to the manufacturer’s instructions to obtain the final injectable biorevitalising solution.
  • Non-crosslinked hyaluronic acid ensures deep hydration and a subtle filling effect without volumising like a traditional filler, while the amino acid cluster provides substrates for collagen synthesis (Amino Acid Replacement Therapy).

Packaging

  • Each box contains:
  • • 1 x 1.5 ml glass disposable prefilled syringe with sterile gel of sodium hyaluronate (high molecular weight, 20 mg).
  • • 1 x 1.0 ml glass bottle containing a sterile solution or powder of amino acids (80 mg).
  • • Package insert with instructions for preparation, indications, contraindications and injection guidelines.
  • No needles are included in the standard pack.
  • Outer carton labelled with product name (Jalupro HMW), batch number, expiry date, manufacturer details and device classification.

Usage

  • For medical use only; Jalupro HMW must be prepared and injected by suitably trained and qualified healthcare professionals in an appropriate clinical setting.
  • Immediately before injection, reconstitute according to the official instructions for use: combine the contents of the prefilled sodium hyaluronate syringe (1.5 ml) with the amino acid bottle (1 ml) if required by the specific presentation, or use sequentially in line with the manufacturer protocol.
  • Use aseptic technique throughout preparation and injection.
  • The solution is injected into the superficial to mid-dermis (papillary and/or reticular dermis) using a fine needle, typically 30G, with linear, serial puncture, fan or grid techniques as recommended by the manufacturer.
  • Indicated injection areas include the face, neck, décolleté, underarms, hands, inner thighs, abdomen and knee region; treat according to the patient’s individual ageing pattern and clinical assessment.
  • Typical treatment schedule for Jalupro HMW consists of 2 sessions spaced about 20 days apart, with volumes and patterns adjusted to indication and skin condition; additional injections may be performed at the doctor’s discretion and a maintenance session is usually recommended every 6 months or as required.
  • Post-treatment, gently massage the treated area if appropriate to ensure even distribution and reduce visible papules.
  • Advise patients to avoid make-up on treated areas for at least 12–24 hours, intense physical exercise, saunas/steam rooms and significant sun or heat exposure for a few days post-procedure.
  • Emphasise the use of broad-spectrum high-SPF sunscreen and supportive skincare to maintain results.
  • Dispose of any unused solution after the session; do not store or reuse. Discard all used syringes, bottles and needles in appropriate sharps containers according to local regulations.

Contraindications

  • Known hypersensitivity or allergy to hyaluronic acid, any of the amino acids (glycine, L-proline, L-leucine, L-lysine HCl) or any excipients in the formulation.
  • Active skin infections, inflammation, dermatitis, or open wounds at or near the intended injection sites.
  • History of severe anaphylactic reactions to injectable products unless thoroughly evaluated and deemed safe by a specialist.
  • Uncontrolled autoimmune diseases or marked immunosuppression where intradermal biorevitalisation is considered inappropriate by the treating physician.
  • Known bleeding disorders or current significant anticoagulant/antiplatelet therapy without appropriate risk assessment and periprocedural management.
  • Pregnancy and breastfeeding, due to insufficient safety data (use is generally not recommended).
  • Recent aggressive dermatologic procedures (deep chemical peels, ablative lasers, dermabrasion) in the planned area that have not fully healed or fall within a contraindicated interval.
  • Use in patients unwilling or unable to follow post-treatment care instructions, especially regarding sun protection.

Adverse Effects

  • Common, usually transient injection-site reactions such as redness (erythema), swelling, tenderness, itching and mild pain.
  • Small papules or nodules at injection points, typically resolving over hours to a few days as the product diffuses.
  • Bruising or ecchymosis, particularly in more vascular areas or in patients taking anticoagulant/antiplatelet medications.
  • Temporary irregularities or mild asymmetry related to swelling or product distribution, generally improving as oedema subsides.
  • Infrequent local infections or abscess formation if aseptic technique is not strictly followed.
  • Rare hypersensitivity or allergic reactions, which may be associated with more pronounced swelling, redness, pruritus or systemic symptoms; these require prompt medical evaluation.
  • As with all injectable dermal procedures, very rare but serious complications such as vascular compromise, tissue necrosis or granuloma formation are possible and must be recognised and managed according to established aesthetic medicine guidelines.

Storage Conditions

  • Store at controlled room temperature as specified by the manufacturer (commonly between about 2 °C and 25 °C).
  • Do not freeze.
  • Keep in the original outer carton to protect from light and contamination until time of use.
  • Do not use after the expiry date printed on the packaging.
  • Once opened or prepared, the product is intended for immediate use only and any remaining solution must be discarded; it should not be stored for reuse.
  • Keep out of the reach and sight of children and unauthorised persons.

Duration

A typical initial course consists of 2 treatment sessions performed approximately 20 days apart. Clinical improvements generally persist for up to about 6 months, depending on age, skin condition and lifestyle, after which maintenance treatment (often once every 6 months or as clinically indicated) is recommended to sustain results.

Onset

Initial improvements in hydration, radiance and skin softness are often noticeable within days to a few weeks after the first session. More pronounced changes in firmness, wrinkle depth and scar appearance usually become evident after completion of the treatment course and continue to develop over several weeks as collagen remodelling progresses. Results can last for around 6 months before gradually declining.

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