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Nucleofill Age – (Medium Plus 2.5%) 1 x 2 ml

Nucleofill Age – (Medium Plus 2.5%) 1 x 2 ml

Nucleofill

Skin boosters
  • CE Marked medical device for aesthetic intradermal use, as indicated by distributors describing Nucleofill Age 2.5% as CE marked for safety.
  • Manufactured under medical device quality management systems consistent with ISO 13485 (as stated for the Nucleofill range by Promoitalia and authorised distributors).
Polynucleotide skin booster

Description

Nucleofill Age (Medium Plus 2.5%) is a medium-viscosity injectable polynucleotide gel designed as a skin booster for intensive anti-ageing treatment. With a 2.5% concentration of highly purified polynucleotides, it provides deep, long-lasting hydration while stimulating collagen production to improve skin elasticity and firmness. The product helps combat free radicals that contribute to skin ageing and is indicated for biorestructuring of deep tissues, soft tissue lifting and the improvement of wrinkles, scars and overall skin quality on the face, neck and décolletage. It is supplied as a sterile 1 x 2 ml vial for professional use only.

Bnefits

  • Delivers intense and long-lasting skin hydration.
  • Stimulates collagen production to improve skin elasticity and firmness.
  • Medium-viscosity polynucleotide gel that plumps and smooths the skin surface.
  • Helps combat free radicals, reducing oxidative stress and visible signs of ageing.
  • Supports biorestructuring of deep tissues for improved skin density and quality.
  • Provides a lifting and tightening effect with more youthful, radiant complexion.
  • May improve the appearance of depressed and surgical scars as part of a treatment plan.
  • Non–hyaluronic-acid formulation for patients seeking an alternative biostimulant approach.

Indications

  • Face (cheeks, forehead, perioral and periorbital areas).
  • Neck and décolletage.
  • Skin with signs of ageing such as loss of elasticity, fine lines and wrinkles.
  • Dull, tired, dehydrated or photo-damaged skin requiring deep biorestructuring.
  • Depressed and certain surgical scars, as assessed by a qualified practitioner.
  • Pre- and post-surgical aesthetic treatment support to improve tissue quality (at clinician discretion).

Composition

  • Polynucleotides 2.5% (25 mg/ml) in injectable gel form.
  • Physiological buffer and saline solution suitable for intradermal use.
  • No hyaluronic acid listed in composition.
  • Does not contain lidocaine.

Formulation

  • Medium-viscosity, sterile, pyrogen-free polynucleotide gel.
  • Polynucleotide concentration: 2.5%.
  • Intended for intradermal / subdermal injection for aesthetic skin biostimulation.
  • Single-use vial for professional administration only.

Packaging

  • 1 x 2 ml sterile vial of Nucleofill Age (Medium Plus 2.5%) polynucleotide gel.
  • Supplied in a box with product labelling, batch number and expiry date.
  • Contains product information leaflet for professional users.
  • Needles and syringes are not included and must be supplied separately.

Usage

  • For professional use only: to be administered by suitably trained healthcare professionals experienced in injectable aesthetic procedures.
  • Injection protocol typically involves intradermal or subdermal micro-injections or linear threading in indicated areas, according to manufacturer and local clinical guidelines.
  • Treatment areas commonly include face (cheeks, forehead, perioral and periorbital regions), neck and décolletage; the exact pattern and depth of injection are determined by the treating practitioner.
  • Aseptic technique must be strictly followed to minimise the risk of infection.
  • Patients should be informed about expected post-treatment reactions such as redness, swelling and bruising, and advised to avoid makeup, excessive heat, UV exposure, saunas, swimming pools and strenuous exercise for at least 24–48 hours or as directed by the practitioner.
  • Do not inject into areas with active infection, inflammation or compromised skin barrier.
  • Dispose of the vial and all sharps immediately after use; do not reuse any remaining product.

Contraindications

  • Known hypersensitivity or allergy to polynucleotides or any component of the formulation.
  • Active skin infections or inflammatory conditions in the intended treatment area (e.g. bacterial, viral, fungal or herpetic lesions).
  • Autoimmune diseases or severe systemic illnesses where injectable aesthetic treatment is considered inappropriate by the treating physician.
  • Pregnancy and breastfeeding due to limited safety data; use is generally not recommended.
  • Bleeding disorders or current anticoagulant therapy that significantly increase the risk of bruising or haematoma, unless carefully evaluated by the clinician.
  • History of severe keloid or hypertrophic scarring in treated areas, unless risk–benefit is specifically assessed.
  • Recent aggressive aesthetic procedures (deep peels, ablative lasers, surgery) in the same area until full healing has occurred.

Adverse Effects

  • Transient injection-site reactions such as redness, swelling, tenderness, bruising, itching or mild pain.
  • Temporary nodules, induration or unevenness at injection points, usually resolving spontaneously or with conservative management.
  • Rare risks associated with injectable treatments, including local infection, abscess, granuloma formation, hypersensitivity reactions or vascular compromise; these require prompt medical evaluation.
  • Potential temporary exacerbation of underlying inflammatory skin conditions in the treated area.
  • As with all aesthetic procedures, results and tolerance vary between individuals and a lack of desired effect is possible despite correct technique.

Storage Conditions

  • Store in a cool, dry place, generally between 2°C and 25°C, as per typical injectable device storage recommendations.
  • Do not freeze; protect from excessive heat and direct sunlight.
  • Keep in original packaging until use to protect from light and contamination.
  • Do not use after the expiry date printed on the packaging.
  • Single-use medical device: discard any unused product after first opening in accordance with local sharps and clinical waste regulations.

Duration

Clinical protocols commonly recommend a course of 2\u20134 treatment sessions spaced approximately 2\u20134 weeks apart, with maintenance treatments as needed every several months depending on skin condition, ageing severity and practitioner assessment.

Onset

Patients may notice initial improvement in hydration and radiance within days to a few weeks after treatment, with progressive enhancement in firmness, elasticity and wrinkle smoothing developing over subsequent sessions as collagen remodelling occurs.

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