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Nucleofill Hair Polynucleotide (Medium Plus)

Nucleofill Hair Polynucleotide (Medium Plus)

Nucleofill

Hair booster injectable
  • CE Marked medical device in the European market
  • Manufactured and controlled according to European medical device quality and safety standards
  • Professional Use Only injectable product distributed through regulated medical and aesthetic supply channels
Polynucleotide scalp mesotherapy / bio-restructuring gel

Description

Nucleofill Hair Polynucleotide (Medium Plus) is an injectable polynucleotide gel specifically designed for scalp and hair revitalisation. Developed by Promoitalia Medical Aesthetics, it uses highly purified polymerised polynucleotides to nourish and biostructure the hair follicle environment, improve scalp microcirculation, and support hair regrowth. The treatment targets hair weakening and early hair loss, including androgenetic alopecia and postpartum thinning, and can also be used on the eyebrows and beard. Supplied as a sterile 2 ml pre-filled syringe, it is administered by intradermal/mesotherapy techniques in a series of sessions to reduce shedding, increase density and thickness, and improve overall scalp health.

Bnefits

  • Reduces hair loss and thinning by improving hair follicle trophism
  • Stimulates hair growth and increases hair density and thickness
  • Improves scalp microcirculation, oxygenation, and nutrient supply
  • Provides deep, long-lasting biostructuring of the scalp tissue
  • Enhances hair quality, strength, and overall vitality
  • Supports pre- and post-hair transplant protocols
  • Can be used for scalp, eyebrow, and beard revitalisation
  • Offers antioxidant protection via polymerised polynucleotides
  • Provides long-lasting results, typically maintained for around 6–12 months

Indications

  • Hair loss and hair weakening
  • Androgenetic alopecia (male and female pattern hair loss)
  • Incipient effluvium (early stages of excessive hair shedding)
  • Telogen effluvium and stress- or hormone-related shedding
  • Postpartum hair loss
  • Pre- and post-operative support for hair transplant procedures
  • Thinning of eyebrows
  • Beard thinning or patchy beard density
  • General scalp revitalisation and improvement of hair quality

Composition

  • Polymerised polynucleotides (sodium DNA), highly purified and of natural origin
  • Polynucleotide gel containing 20 mg of polynucleotides in 2 ml
  • Medium molecular weight polynucleotides (approximately 1,500 kDa)
  • Sterile, pyrogen-free injectable gel formulation

Formulation

  • Injectable polynucleotide bio-restructuring gel for scalp and hair
  • Often described as a 2% polynucleotide gel, supplied as 2 ml of product
  • Designed for intradermal / superficial mesotherapy administration to the scalp
  • High-viscosity gel with pH approximately 6.8–7.2 and viscosity around 35–43 Pa·s
  • Sodium DNA–based biostimulant targeting hair follicles and scalp tissue

Packaging

  • Box with 1 pre-filled syringe containing 2 ml of polynucleotide gel
  • Typically supplied with 2 sterile 30G x 12–13 mm needles
  • Includes instructions for use and treatment protocol guidance
  • Professional-use-only medical aesthetic presentation

Usage

  • For professional use only; administration should be performed by trained, medically qualified practitioners.
  • Indicated for superficial intradermal or mesotherapy injection into the scalp (and, where appropriate, eyebrows or beard).
  • Inject using micro-deposit / mesotherapy technique: small boluses (commonly around 0.05 ml per point) placed superficially in the scalp.
  • Standard protocol widely used: 4 treatment sessions – 2 sessions spaced 7 days apart, followed by 2 sessions spaced 14 days apart.
  • Alternative protocols may involve 3–4 sessions every 2–4 weeks, depending on clinical judgement and severity of hair loss.
  • Maintenance sessions are commonly recommended every 2–3 months or approximately every 6–12 months, according to patient response.
  • Before injection, cleanse and disinfect the scalp; avoid injecting into areas with active infection or inflammation.
  • Can be used alone or in combination protocols (e.g., alongside PRP or hair transplant procedures) following appropriate clinical guidance.
  • Do not exceed the total volume recommended per treatment area (typically up to 2 ml per session for the scalp).
  • Post-treatment: patients should avoid washing the scalp, intense physical exertion, and excessive sun or heat exposure for at least 24–48 hours, as per clinic protocol.

Contraindications

  • Known hypersensitivity or allergy to polynucleotides, sodium DNA, or any component of the product
  • Patients under 21 years of age
  • Pregnancy and breastfeeding
  • Active scalp infections or inflammatory skin conditions at the injection site
  • Current or past history of certain cancers as advised by the treating physician
  • Coagulation disorders or patients with impaired blood clotting
  • Active herpes infections in the treatment area
  • Severe systemic illnesses or uncontrolled autoimmune diseases
  • Any general contraindications to injectable mesotherapy procedures as assessed by a medical professional

Adverse Effects

  • Transient redness (erythema) at injection sites
  • Mild to moderate swelling or oedema at treated areas
  • Itchiness or pruritus of the scalp
  • Dryness or temporary discomfort of the scalp
  • Bruising or small haematomas at injection points
  • Localized tenderness or soreness after treatment
  • Rarely, allergic-type reactions (e.g., persistent itching, swelling) requiring medical evaluation
  • Very rarely, infection or nodules at injection sites if aseptic technique and aftercare are not strictly followed

Storage Conditions

  • Store at a controlled temperature, typically between 2°C and 25°C (some sources specify 2–8°C for the Nucleofill range); follow the instructions on the actual packaging.
  • Keep in a cool, dry place, protected from direct sunlight and moisture.
  • Do not freeze the product.
  • Store in the original box until use to protect from light and contamination.
  • Keep out of reach of children.
  • Use only within the expiry date printed on the packaging and do not use opened or damaged syringes.

Duration

Results are typically maintained for approximately 6\u201312 months, depending on individual physiology, lifestyle, severity of hair loss, and adherence to maintenance sessions.

Onset

Effects are gradual; improvements in hair shedding, density, and quality generally become noticeable over the course of the initial 3\u20134 treatment sessions and continue to evolve over subsequent months.

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