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Nucleofill SOFT+ CE (EYES)

Nucleofill SOFT+ CE (EYES)

Nucleofill

Injectable periocular skin booster
  • CE Marked medical device for use in the periocular area
  • Manufactured according to European medical device quality and safety standards for injectable biostimulating gels
  • Distributed through professional aesthetic and medical supply channels that comply with regional regulatory requirements
  • Intended for use only by qualified healthcare professionals in accordance with local regulations and manufacturer guidance
Under-eye polynucleotide bio-stimulator

Description

Nucleofill SOFT+ CE (EYES), also known as Nucleofill Eyes (Soft Plus), is a CE-marked polynucleotide-based injectable specifically developed for the delicate under-eye and periocular area. The product contains highly purified, low-molecular-weight sodium DNA (polynucleotides) in a sterile gel that deeply hydrates, brightens and biostimulates the thin skin around the eyes. By improving microcirculation, stimulating fibroblasts and enhancing collagen and elastin production, it targets dark circles, fine lines, crepey texture and under-eye puffiness. It is used by trained medical professionals as a regenerative alternative or complement to traditional tear trough fillers, providing natural-looking rejuvenation, improved skin quality and long-term tissue regeneration rather than volumisation alone.

Bnefits

  • Reduces the appearance of dark circles under the eyes
  • Softens fine lines and superficial wrinkles around the eyes
  • Improves under-eye puffiness and eye bags for a fresher look
  • Deeply hydrates and nourishes the thin periocular skin
  • Stimulates collagen and elastin synthesis for firmer, more elastic skin
  • Brightens and evens the tone of the under-eye area
  • Offers antioxidant protection and supports tissue regeneration
  • Improves skin texture, radiance and overall eye-area vitality
  • Provides a regenerative alternative or adjunct to tear trough filler
  • Suitable for sensitive, delicate skin around the eyes

Indications

  • Periocular and under-eye skin ageing
  • Dark circles and under-eye pigmentation caused by vascular and structural changes
  • Fine lines and superficial wrinkles around the eyes (crow’s feet, lower eyelid lines)
  • Mild to moderate under-eye bags and puffiness
  • Crepey, thin, dehydrated skin in the periocular area
  • Loss of firmness and elasticity around the eyes
  • Patients unsuitable or not ready for tear trough hyaluronic acid filler
  • Adjunctive treatment before or after blepharoplasty or lifting procedures (according to clinician judgement)
  • General biostimulation and quality improvement of the eye-contour skin

Composition

  • Polymerised polynucleotides (sodium DNA) of low molecular weight
  • Polynucleotide gel 40 mg in 2 ml (20 mg/ml) in many technical descriptions
  • Sodium DNA of natural origin with high purity
  • Excipients: Aqua (Water), Sodium Chloride, Sodium DNA as listed on several distributor ingredient summaries

Formulation

  • Sterile, low-viscosity sodium DNA-based polynucleotide gel for periocular injection
  • Low-molecular-weight polynucleotide chain fragments designed for rapid tissue penetration
  • Molecular weight approximately 50–100 kDa for the polynucleotide fragments, with product-level molecular weight specification around 1,500 kDa in some technical sheets
  • pH in the range of approximately 6.8–7.2
  • Viscosity reported around 35–43 Pa·s at specified shear conditions
  • Non-crosslinked bio-stimulating gel (not a volumising filler) aiming at tissue regeneration and hydration rather than structural filling

Packaging

  • Box containing 1 x 2 ml pre-filled sterile syringe of Nucleofill Soft Plus Eyes gel
  • Typically supplied with 2 sterile 30G x 12 mm (or similar) needles for injection
  • Single-use syringe intended for one patient only
  • Includes instructions for use and treatment guidance for healthcare professionals
  • CE-marked medical device packaging with batch number and expiry date clearly indicated

Usage

  • For professional use only; must be administered by appropriately trained and qualified medical practitioners familiar with periocular injections.
  • Designed for superficial intradermal / micro-wheal (micro-bleb) technique in the periocular region, including lower eyelid, tear trough area, crow’s feet and upper eyelid margin where clinically appropriate.
  • A commonly referenced technique uses micro-deposits of approximately 0.05 ml per wheal, spaced about 0.5 cm apart, placed very superficially in the skin.
  • Standard treatment protocols generally recommend 2–3 initial sessions spaced about 2–4 weeks apart, depending on the clinic’s protocol and patient needs.
  • Some protocols suggest an initial course of 3 sessions, followed by maintenance treatments every 3–6 months to sustain results.
  • The injection should avoid intravascular administration; aspirate according to clinic protocol and inject slowly with careful anatomical awareness of vessels and orbital structures.
  • Do not inject into areas with active infection, severe inflammation, or compromised skin barrier; postpone treatment until resolved.
  • Before treatment, thoroughly cleanse and disinfect the skin around the eyes and remove all cosmetics.
  • Post-treatment recommendations often include avoiding makeup, rubbing the treated area, intense exercise, saunas, swimming and excessive sun or heat exposure for at least 24 hours, following clinic instructions.
  • The total injected volume per session is typically the contents of one 2 ml syringe for both eyes, adjusted by the practitioner according to indications and patient anatomy.
  • Can be combined, under clinician guidance, with other procedures such as botulinum toxin, peels, laser, or surgery in tailored treatment plans, with appropriate spacing between procedures.

Contraindications

  • Known hypersensitivity or allergy to polynucleotides (sodium DNA) or any component of the product
  • Pregnancy and breastfeeding (as a precaution, pending sufficient safety data)
  • Patients under the age specified by local regulations and clinic policy (commonly under 18 years)
  • Active skin infections, inflammation or dermatological diseases in the intended treatment area (e.g., dermatitis, eczema, bacterial or viral infections including active herpes simplex)
  • History of severe allergic reactions or anaphylaxis to injectable products with similar excipients
  • Uncontrolled systemic diseases, significant autoimmune or connective tissue disorders, unless cleared by the treating physician
  • Coagulation disorders, use of anticoagulant therapy or conditions that significantly increase bleeding risk, unless carefully assessed and managed by a physician
  • History of keloid or hypertrophic scarring in the periorbital area or other factors that would contraindicate injectable biostimulators by clinical judgement
  • Any general contraindication to aesthetic injectable procedures as determined by a qualified healthcare professional

Adverse Effects

  • Transient redness (erythema) at the injection sites around the eyes
  • Mild to moderate swelling or oedema in the treated periocular area, usually resolving within a few days
  • Minor bruising or small haematomas at injection points, particularly in patients prone to bruising
  • Local tenderness, discomfort or tight sensation following treatment
  • Temporary itching, dryness or mild irritation in the treated skin
  • In rare cases, delayed hypersensitivity or inflammatory reactions, which may require medical assessment and management
  • Very rare risk of infection at injection sites if aseptic technique or aftercare is inadequate
  • As with any periocular injection, inadvertent intravascular injection or injury to local structures is a theoretical risk and emphasises the need for skilled administration

Storage Conditions

  • Store in a clean, dry place at a controlled temperature, commonly indicated as between 2°C and 25°C (follow the exact storage range on the packaging).
  • Protect from direct sunlight and excessive heat or cold.
  • Do not freeze the product.
  • Keep in the original outer carton until use to protect from light and contamination.
  • Do not use after the expiry date printed on the packaging.
  • Single-use device: do not resterilise or reuse a previously opened syringe.
  • Keep out of reach of children.

Duration

Clinical protocols and user reports commonly indicate that, after an initial course of 2\u20133 sessions, results such as improved hydration, brightness and fine-line reduction can be maintained for several months, with many practitioners recommending maintenance sessions every 3\u20136 months and overall effect duration in the range of approximately 6\u201312 months depending on individual factors.

Onset

Patients often notice an improvement in hydration, smoothness and brightness in the under-eye area within days to a few weeks after the first session, with more pronounced and lasting results typically developing progressively over the full course of 2\u20133 treatments and ongoing collagen and elastin remodelling over subsequent weeks.

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