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Nucleoskin (Nucleoskin Topic)

Nucleoskin (Nucleoskin Topic)

Nucleoskin

Skin booster / bio-restructuring solution
  • Manufactured by Promoitalia in Italy in line with the company’s stated quality and safety standards for professional aesthetic products
  • Marketed as a professional bio Restructuring solution for skin rejuvenation, with information and usage guidance directed to healthcare professionals in accordance with Italian Ministry of Health rules for medical devices and accessories
  • In the USA, explicitly marketed for topical use only and not as a drug, with a disclaimer that any non Topical use is not authorised by Promoitalia
PDRN (polynucleotide) + hyaluronic acid + glutathione skin booster for face, body and periocular areas

Description

Nucleoskin (Nucleoskin Topic) is a professional bio-restructuring skin booster developed by Promoitalia, formulated as a powerful PDRN-based solution that combines polydeoxyribonucleotides, hyaluronic acid and glutathione. It is designed to provide a plumping, lifting and regenerating action for ageing and photo-damaged skin. Marketed as a ‘liquid lifting’ treatment, Nucleoskin stimulates rejuvenation processes, tones tissues, reduces wrinkles and skin depressions, and offers strong antioxidant protection against free radical damage. The highly purified polynucleotide matrices activate skin bio-regeneration at both deep levels (adipose and bone tissue) and within the dermis via fibroblast stimulation. It can be used on the face, periocular area and body to improve skin texture, tone, hydration and the appearance of fine lines, small depressed scars and periocular wrinkles. Nucleoskin can be applied with a dermapen or dermaroller for transdermal delivery and, in some clinical settings outside the USA, via microinjection or hyaluron pen according to protocol and local regulation.

Bnefits

  • Provides a ‘liquid lifting’ effect by stimulating tissue rejuvenation and toning
  • Plumping and slight filling effect that reduces wrinkles and skin depressions
  • Deep bio-restructuring of the dermis and support of deeper tissues
  • Intense moisturising action due to hyaluronic acid, improving skin hydration and elasticity
  • Antioxidant effect from glutathione, defending the skin against free radicals and oxidative stress
  • Stimulates fibroblasts and dermal regeneration via PDRN (polydeoxyribonucleotides)
  • Improves the appearance of small depressed scars and periocular wrinkles
  • Supports pre- and post-surgical protocols (e.g. blepharoplasty, lifting, resurfacing laser) when used according to professional guidance
  • Enhances overall skin radiance, smoothness and firmness for mature, dull or damaged skin

Indications

  • Signs of skin ageing including fine lines and moderate wrinkles
  • Skin laxity and loss of firmness on the face and selected body areas
  • Dry, dehydrated, rough or dull skin needing intensive hydration and biorestructuring
  • Small depressed scars, including superficial post-acne scars
  • Periocular wrinkles and under-eye skin ageing in appropriately diluted protocols
  • Photo-damage and oxidative stress-related skin changes
  • Supportive treatment in pre- and post-surgical cosmetic procedures such as blepharoplasty, lifting and laser resurfacing (as part of a professional treatment plan)
  • General regenerative and rejuvenating treatment for mature or aging skin on face, neck and body

Composition

  • Biologically-derived PDRN (polydeoxyribonucleotides) 2% with high molecular weight (approximately 2,500 kDa)
  • Hyaluronic acid 10 mg/ml crosslinked with BDDE (low-concentration, slightly filling HA matrix)
  • Glutathione 2 mg/ml as an antioxidant component

Formulation

  • Bio-restructuring topical/mesotherapy solution containing PDRN, crosslinked hyaluronic acid and glutathione
  • Highly purified polynucleotidic matrices designed to activate skin bio-regeneration at deep (adipose and bone) and dermal levels
  • Low-concentration crosslinked hyaluronic acid providing a slight filler effect and hydration
  • Glutathione-based antioxidant system to counter free radical damage and support proper cellular defence
  • Professional-use solution suitable for application with microneedling devices (dermapen/dermaroller) or, in some protocols, via microinjection or hyaluron pen according to local regulations

Packaging

  • Box containing 5 vials of 3 ml each (total 15 ml) as described by Promoitalia
  • Vials intended for multiple facial or body applications; up to approximately 15 applications per box depending on area and protocol
  • Professional packaging with product name, ingredient listing, batch number and expiry date
  • Accompanied by manufacturer/product information and protocol guidance for trained practitioners

Usage

  • For professional use only; treatment should be carried out by qualified clinicians or aesthetic practitioners trained in the use of PDRN-based skin boosters and microneedling or injection techniques.
  • Nucleoskin can be applied using a dermapen or a dermaroller; the intensity of treatment (needle depth, passes and frequency) must be calibrated according to the skin type, clinical indication and individual patient characteristics.
  • UKMEDI guidance and related protocols describe its use also via hyaluron pen in some regions (excluding the vermilion area), and certain clinics use microinjection or cannula techniques for subdermal placement according to local regulations and the consented treatment plan.
  • For facial treatments, typically 1–2 ml of product are used per session; an example protocol is approximately 1.5 ml for the entire face, using around 0.025 ml per micro-application (about 60 micro applications per full face).
  • For body treatments (e.g. areas with laxity, texture changes or small depressed scars), quantities are higher; one protocol cites around 3 ml per session with 0.1 ml per application point.
  • Standard treatment plans often recommend 4–6 sessions for face/body, one session every 20–25 days, depending on clinical assessment and patient response.
  • For the periocular area, the product is typically diluted 1:1 with physiological saline (1 ml Nucleoskin + 1 ml saline); about 0.025 ml per micro-application is used, with 3–4 sessions recommended at 28-day intervals in the protocol provided by UKMEDI.
  • The treatment area should be thoroughly cleansed and disinfected prior to application; when using microneedling, apply according to device manufacturer guidelines and within safe depth limits for each region of the face or body.
  • In injection-based protocols (where permitted), Nucleoskin Topic is applied into the subdermal tissue using micro-bolus or mesotherapy techniques for treatment of facial lines, wrinkles and under-eye ageing, following detailed consent and risk explanation as documented in clinical consent forms.
  • Post-procedure, patients are typically advised to avoid makeup on the treated area for several hours, minimise touching or rubbing, and avoid intense exercise, sauna/steam heat, and excessive sun exposure for at least 24–48 hours, following clinic-specific aftercare instructions.
  • Practitioners should adhere to Promoitalia’s guidance and any regional regulations (including the manufacturer’s USA topical-use-only policy for that region) regarding route and method of administration.

Contraindications

  • Known hypersensitivity or allergy to polydeoxyribonucleotides (PDRN), hyaluronic acid, glutathione or any other component of the formulation
  • Pregnancy and breastfeeding, as a precaution where dedicated safety data are limited
  • Patients under the legal age for aesthetic procedures according to local regulations (commonly under 18 years of age)
  • Active skin infections, inflammation or dermatologic conditions (e.g. bacterial, viral or fungal infections, active herpes simplex, dermatitis) at or near the intended treatment area
  • Compromised skin barrier or open wounds in the treatment zone
  • Severe autoimmune disorders or uncontrolled systemic disease, unless carefully evaluated and cleared by the treating physician
  • Known tendency to keloid or hypertrophic scarring in the treatment area, depending on practitioner risk assessment
  • Use of systemic anticoagulant or antiplatelet therapy, or bleeding disorders, which may increase the risk of bruising and bleeding (requires physician assessment and potential adjustment)
  • Any general contraindication to microneedling, hyaluron pen application or injectable aesthetic procedures as determined by a qualified healthcare professional

Adverse Effects

  • Transient erythema (redness) and mild swelling at treatment sites following microneedling or injections
  • Temporary pinpoint bleeding and mild oozing commonly associated with microneedling treatments
  • Mild discomfort, burning or stinging sensation during and shortly after the procedure
  • Bruising or small haematomas, particularly when injection or hyaluron pen techniques are used
  • Temporary dryness, itching or sensitivity of the treated skin
  • Rare risk of infection at treatment sites if aseptic technique or aftercare is inadequate
  • With injectable use (where practised), additional risks described in consent forms include swelling, prolonged pain, migration or deformity of product, nerve or vessel injury, lidocaine or anaesthetic reactions and, in rare cases, treatment failure or lack of visible effect
  • As with any aesthetic procedure, unforeseen or idiosyncratic reactions may occur; patients should be fully counselled on risks and monitored appropriately

Storage Conditions

  • Store in accordance with the instructions on the product packaging and manufacturer leaflet.
  • Keep vials in a cool, dry place, protected from direct sunlight and excessive heat.
  • Do not freeze the product.
  • Store in the original box until use to protect from light and contamination.
  • Do not use after the expiry date printed on the package.
  • Single-use vials are intended for professional use; any unused product from an opened vial should be discarded according to local medical waste regulations.
  • Keep out of reach of children and unauthorised persons.

Duration

Clinical and marketing descriptions indicate that results are progressive and tend to persist for several months after completing a course of 3\u20136 sessions; many clinics recommend periodic maintenance treatments (for example, every few months) to sustain hydration, firmness and overall skin quality, with exact duration varying according to patient age, skin condition, lifestyle and protocol used.

Onset

Initial improvements in skin hydration, smoothness and radiance are often reported within days to weeks after the first session, with more noticeable lifting, plumping and textural improvements typically becoming evident over the course of multiple sessions as dermal regeneration and collagen remodelling progress.

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