Logo
Plinest 2ml

Plinest 2ml

Plinest

Injectable skin booster
  • Class III CE Marked PN HPT® polynucleotide injectable gel for intradermal use.
  • Manufactured by Mastelli S.r.l. under a certified medical device quality management system (e.g. ISO 13485) in accordance with European medical device regulations.
  • Recognised in clinical literature as a CE Marked PN HPT device for intradermal injection (20 mg/ml polynucleotide gel in 2 ml).
Polynucleotide injectable gel

Description

Plinest 2ml is a polynucleotide-based injectable gel (PN-HPT® – Polynucleotides Highly Purified Technology) developed by Mastelli S.r.l. for intradermal skin biorevitalisation. The product contains highly purified, fish-derived polynucleotides at a concentration of 20 mg/ml in a 2 ml pre-filled syringe and is designed for use on the face, neck and décolletage. By stimulating fibroblast activity, Plinest promotes collagen and elastin production, improves hydration and skin quality, and is particularly indicated for prevention and maintenance of youthful skin quality in younger patients as well as for skin priming and treatment of early ageing signs.

Bnefits

  • Stimulates fibroblast activity, enhancing endogenous collagen and elastin production for long-term skin rejuvenation.
  • Improves skin turgidity, elasticity and tonicity, leading to firmer and more resilient skin.
  • Provides deep hydration and improves overall skin radiance and texture.
  • Ideal for prevention and maintenance of younger patients’ skin quality and for early signs of ageing.
  • Supports skin priming and recovery in fibrous areas such as acne scars and areas with fine lines and mild laxity.
  • Non-volumising biostimulator that improves skin quality without creating excessive bulk or projection.
  • Highly purified PN-HPT® polynucleotides with high biocompatibility and a strong safety profile.
  • Supplied ready to use in a 2 ml pre-filled syringe with fine gauge needles for precise intradermal delivery.

Indications

  • Biorevitalisation and rejuvenation of the face, neck and décolletage.
  • Prevention and maintenance of youthful skin quality in younger patients.
  • Improvement of fine lines, mild skin laxity and early photoageing.
  • Skin quality enhancement and priming prior to or following other aesthetic procedures (e.g. lasers, peels, microneedling).
  • Supportive treatment for fibrous or scarred areas such as acne scars, where stimulation of dermal regeneration is desired.

Composition

  • Highly purified polynucleotides (PN-HPT®) 20 mg/ml (40 mg total in 2 ml), derived from fish DNA.
  • Sterile, apyrogenic buffered saline solution as carrier (exact excipients not fully specified in public sources).

Formulation

  • Sterile, apyrogenic, viscoelastic injectable gel for intradermal administration.
  • Concentration: 20 mg/ml highly purified polynucleotides (PN-HPT®) in a 2 ml pre-filled syringe.
  • Class III CE-marked medical device for professional use only.
  • Non-crosslinked, non-hyaluronic acid, non-volumising biostimulatory skin booster.

Packaging

  • 1 x 2 ml pre-filled syringe of Plinest polynucleotide gel.
  • 2 x 30G 1/2" disposable sterile needles included in each box.
  • Single-use, sterile packaging intended for one patient treatment session.

Usage

  • For professional use only by suitably trained healthcare practitioners experienced in injectable aesthetic treatments.
  • Administer Plinest intradermally in the indicated areas (face, neck, décolletage) using appropriate injection techniques such as micro-papular, serial puncture or linear retrograde threading, according to skin thickness and treatment plan.
  • Follow recommended protocols, typically one session every 14–21 days for 3–4 sessions in an initial course, adjusting according to individual patient needs and clinical judgement.
  • Inject small aliquots intradermally to create micro-papules or lines of product in the mid to superficial dermis, avoiding intravascular injection and following standard PN-HPT injection guidance.
  • After injection, gently massage the treated areas if appropriate to aid even distribution of the product.
  • Advise patients on standard post-treatment care, including avoiding excessive sun or heat exposure, strenuous exercise and makeup on treated areas for a short period as per clinic protocol.
  • Dispose of the syringe, needles and any unused product immediately after treatment in accordance with local clinical waste and sharps regulations; do not reuse or resterilise.

Contraindications

  • Known hypersensitivity or allergy to fish-derived products, polynucleotides or any component of the formulation.
  • Presence of active skin infection, inflammation, or dermatological disease at or near the intended injection site.
  • Severe systemic illness, uncontrolled autoimmune disease or other conditions in which injectable aesthetic procedures are contraindicated, unless the risk–benefit has been carefully assessed.
  • History of severe hypertrophic scarring or keloid formation in the planned treatment area.
  • Pregnancy or breastfeeding, and patients under 18 years of age, due to lack of sufficient safety data.
  • Use by non-medical personnel or self-administration.

Adverse Effects

  • Common injection-related reactions such as transient redness, swelling, bruising, tenderness or mild pain at the injection site.
  • Temporary papules, nodules or unevenness at injection points, which generally resolve spontaneously over a few days.
  • Occasional itching, warmth or mild sensitivity in treated areas.
  • As with any injectable treatment, rare risks include infection, prolonged inflammation or granulomatous reactions, which may require medical management.
  • Very rare but serious complications associated with intradermal injections, such as vascular compromise or tissue necrosis, may occur if injected intravascularly or with improper technique.

Storage Conditions

  • Store in a cool, dry place away from direct sunlight, within the temperature range specified on the original packaging (typically controlled room temperature).
  • Do not freeze and protect from excessive heat or sudden temperature changes.
  • Keep the syringe in its original box until use to maintain sterility and protect from light and contamination.
  • Do not use the product after the expiry date or if the packaging, syringe or sterility seal is damaged.

Duration

Clinical protocols and fact-sheet data indicate that results progress over several weeks during a course of 3\u20134 sessions and can be maintained for approximately 6\u201312 months, with maintenance treatments typically recommended every 2\u20133 months initially or every 6\u201312 months depending on age, skin status and aesthetic goals.

Onset

Early improvements in hydration and skin softness may be noticeable within days to a few weeks after the first sessions, with more substantial gains in elasticity, texture and fine-line reduction developing gradually over the course of 3\u20135 sessions and continuing to improve over subsequent weeks.

Browse more Injectable skin booster

Top Treatments

Top Cities in the UK