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Rejuran Healer PN 2 × 2 ml

Rejuran Healer PN 2 × 2 ml

Rejuran

Skin booster
  • Rejuran is described by European and Nordic clinics as a CE Marked biostimulation treatment based on polynucleotides extracted from salmon DNA.
  • Manufactured by PharmaResearch Products Co., Ltd., a South Korean pharmaceutical company producing PN Based injectables under medical Device quality Management systems.
  • Clinics and distributors report Rejuran products as CE Certified and approved/registered for use in multiple countries (including Korean MFDS and other regional regulators).
Polynucleotide injectable skin booster for global skin rejuvenation

Description

Rejuran Healer PN 2 × 2 ml is an advanced injectable skin-healing and rejuvenating treatment based on highly purified polynucleotides (PN) extracted from salmon DNA. Supplied as two 2 ml pre-filled syringes, this regenerative skin booster works by stimulating fibroblasts, enhancing collagen and elastin production, improving extracellular-matrix structure, and restoring the skin barrier. It is designed to improve overall skin quality—boosting elasticity, hydration and thickness—while reducing fine lines, wrinkles, enlarged pores, acne scars and uneven texture. Intended for professional use on the face, neck, décolleté and other indicated areas, Rejuran Healer focuses on biostimulation rather than volumising, delivering natural, long-lasting skin improvement from within.

Bnefits

  • Improves skin elasticity and firmness by stimulating collagen and elastin production.
  • Enhances skin hydration and moisture retention for a plumper, healthier appearance.
  • Reduces fine lines and superficial wrinkles, especially in photoaged or thin skin.
  • Repairs and strengthens the skin barrier, supporting better resilience and reduced sensitivity.
  • Normalises skin function, including regulation of sebum (oil) production and overall skin balance.
  • Improves skin tone, brightness and radiance, helping to reduce dullness.
  • Refines skin texture and tightens pores, leading to smoother, more even-looking skin.
  • Helps reduce acne scars and other textural irregularities by promoting dermal regeneration.
  • Increases dermal thickness and density, particularly in thin or damaged skin.
  • Provides natural-looking rejuvenation with minimal downtime when performed by trained professionals.

Indications

  • General skin rejuvenation and quality improvement of the face, neck and décolleté.
  • Fine lines and early wrinkles (periorbital, perioral, forehead, cheeks).
  • Loss of skin elasticity and firmness in photoaged or mature skin.
  • Thin, fragile or damaged skin with impaired barrier function.
  • Enlarged pores and uneven skin texture.
  • Acne scars and other atrophic scars as part of a comprehensive treatment plan.
  • Dull, dehydrated or tired-looking skin requiring biostimulatory revitalisation.
  • Post-procedure skin recovery support (e.g. after lasers or peels), as determined by the practitioner.

Composition

  • Polynucleotides (PN / polydeoxyribonucleotide) 2% derived from salmon DNA (highly purified DNA fragments).
  • Buffered aqueous solution (phosphate buffer and water for injection; exact excipient listing per official pack leaflet).
  • No added hyaluronic acid in the standard Rejuran Healer PN formulation (PN-only biostimulatory solution; check local labelling for any regional variations).

Formulation

  • Injectable, transparent polynucleotide-based skin booster designed for biostimulation rather than volumising filler effect.
  • Contains highly biocompatible PN fragments similar to human DNA, promoting tissue regeneration and dermal repair.
  • Non-cross-linked, non-particulate solution intended for intradermal administration.
  • Regenerative profile focusing on collagen stimulation, extracellular-matrix restoration and barrier repair.
  • Sterile, pyrogen-controlled product supplied in single-patient-use pre-filled syringes.

Packaging

  • Box containing 2 pre-filled syringes of 2 ml each (total 4 ml).
  • Each syringe contains Rejuran Healer PN solution (PN 2% polynucleotides derived from salmon DNA).
  • Fine-gauge injection needles (commonly 30–33G) may be supplied depending on distributor and region.
  • Syringes and needles packaged in sterile blisters.
  • Outer carton with product information, batch number and expiry date.
  • Instructions for use (IFU) / product leaflet and, where applicable, traceability labels for patient records.

Usage

  • For professional use only: Rejuran Healer PN must be administered by appropriately trained and licensed healthcare professionals experienced with injectable skin boosters.
  • Perform a full medical history, skin assessment and indication review; exclude contraindications and obtain informed consent prior to treatment.
  • Cleanse and disinfect the treatment area thoroughly using an appropriate antiseptic solution.
  • Inject Rejuran Healer intradermally using micro-injection techniques (e.g. micro-papular, serial puncture, nappage) with a fine needle (commonly 30–33G), placing small aliquots evenly throughout the treatment zone.
  • Typical treatment areas include the face (periorbital region, cheeks, forehead, nasolabial area), neck, décolleté and, in some protocols, the backs of the hands.
  • Standard protocols often recommend an initial series of 3–4 treatment sessions spaced about 3–4 weeks apart; the exact number of sessions, dose per session and interval should be individualised according to the patient’s skin condition and clinical response.
  • Use slow, controlled injections at the correct intradermal depth; aspirate cautiously where appropriate and avoid high-pressure injections to minimise risk of intravascular placement.
  • After injection, mild massage may be applied to distribute the product evenly and smooth injection papules if clinically appropriate.
  • Advise patients to avoid makeup on treated areas for several hours and to refrain from intense exercise, saunas, hot baths, sunbeds and excessive sun exposure for at least 24 hours or according to clinic protocol.
  • Instruct patients on photoprotection (e.g. regular use of broad-spectrum sunscreen) and general skincare to support optimal outcomes.
  • Always follow the official instructions for use (IFU) supplied with the product and comply with local regulatory and professional guidelines.

Contraindications

  • Known hypersensitivity or allergy to polynucleotides, salmon-derived substances, or any component of the formulation.
  • History of severe allergic reactions or anaphylaxis to injectable medical or cosmetic products.
  • Active skin infections, inflammatory lesions or dermatologic diseases (bacterial, viral such as herpes, or fungal) at or near the intended injection site.
  • Autoimmune diseases or immunocompromised states unless, after careful evaluation, the treating physician judges that the benefits outweigh the risks.
  • Uncontrolled systemic illnesses or acute febrile conditions.
  • Bleeding disorders, coagulation abnormalities, or concurrent use of anticoagulants/antiplatelets that significantly increase bleeding risk, unless properly assessed and managed by a physician.
  • Pregnancy and breastfeeding (generally not recommended due to limited safety data).
  • Patients under 18 years of age.
  • Presence of permanent fillers or other foreign bodies in the proposed treatment area where there could be a risk of interaction, unless assessed and approved by an experienced practitioner.
  • Any general contraindication to injectable aesthetic procedures as determined by the treating healthcare professional.

Adverse Effects

  • Typical, usually mild and transient injection-site reactions such as redness (erythema), small papules, mild swelling or oedema, tenderness, itching or a feeling of tightness.
  • Localised pain or discomfort at injection points, usually resolving within 1–2 days.
  • Small bruises or haematomas at injection sites.
  • Temporary skin sensitivity or mild irritation in treated areas.
  • Short-lived surface irregularities or minor asymmetry, which may require adjustment or additional treatment.
  • Rare delayed inflammatory or hypersensitivity reactions (e.g. prolonged redness, swelling, induration or pruritus) which warrant medical evaluation and appropriate management.
  • Infection at the injection site if aseptic technique is not strictly followed.
  • As with any injectable treatment, very rare but serious complications may occur, including inadvertent intravascular injection leading to tissue ischaemia or necrosis; such events require immediate emergency management by an appropriately trained physician.
  • Any unexpected, persistent or severe adverse effect should be promptly assessed and treated in line with clinical best practice and the product’s IFU.

Storage Conditions

  • Store in accordance with the manufacturer’s labelling, typically in a cool, dry place away from direct sunlight (commonly in the 2–25 °C range).
  • Do not freeze.
  • Keep in the original packaging until use to protect from light and contamination.
  • Avoid exposure to excessive heat or abrupt temperature changes.
  • Do not use after the expiry date printed on the packaging.
  • Use only if the syringe, blister and outer packaging are intact and the solution appears clear and free from visible particles.
  • Single-use sterile device: do not resterilise and do not reuse any opened or partially used syringe.

Duration

After a full course of approximately 3\u20134 sessions at 3\u20134 week intervals, improvements in skin hydration, elasticity, texture and fine lines commonly persist for around 6\u201312 months, depending on individual factors such as age, skin status, lifestyle and adjunctive treatments. Maintenance or top-up sessions (for example every 6\u201312 months) are typically recommended to sustain and enhance results.

Onset

Initial changes in hydration and radiance may be noticeable within days to a few weeks after the first session. More pronounced improvements in elasticity, fine lines, dermal thickness, pore size and overall texture usually develop progressively over 4\u20138 weeks and continue to build with subsequent treatments as collagen and extracellular-matrix regeneration occur.

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