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Rejuran *Rejuvenation with PN (2 x 2ml)

Rejuran *Rejuvenation with PN (2 x 2ml)

Rejuran

Skin booster
  • Described by European clinics and distributors as a CE Marked polynucleotide Based skin booster.
  • Manufactured in South Korea by PharmaResearch Co., Ltd. under medical Device quality Management systems for PN injectables.
  • Approved or registered with regulatory authorities in several markets (including Korean MFDS and other regional regulators) for aesthetic skin Rejuvenation indications.
Polynucleotide injectable skin booster for global skin rejuvenation

Description

Rejuran *Rejuvenation with PN (2 x 2ml) is an injectable skin-healing and rejuvenating treatment based on highly purified polynucleotides (PN) extracted from salmon DNA. Also known as Rejuran Healer PN 2 x 2ml, this biostimulatory skin booster works by stimulating fibroblasts, enhancing collagen production and improving extracellular-matrix structure, while strengthening the skin barrier. It is designed to improve overall skin quality—boosting elasticity and hydration, reducing fine lines and wrinkles, normalising sebum production, and refining tone and texture—on the face, neck, décolleté and other indicated areas. The PN molecules form a biocompatible scaffold that promotes dermal regeneration and long-term skin health rather than a temporary volumising effect.

Bnefits

  • Improves skin elasticity and firmness by stimulating collagen and elastin production.
  • Enhances skin hydration and moisture retention for a plumper, healthier appearance.
  • Reduces fine lines and superficial wrinkles, particularly in photoaged or thin skin.
  • Supports skin repair with improved barrier function, helping to reduce sensitivity and irritation.
  • Normalises skin function, including thickening of thin skin and regulation of oil (sebum) production.
  • Improves overall skin tone, brightness and radiance, reducing the appearance of dullness.
  • Refines skin texture and reduces enlarged pores for smoother, more even skin.
  • Helps improve acne scars and textural irregularities as part of a comprehensive skin-rejuvenation or scar-treatment protocol.
  • Provides a natural-looking rejuvenation effect with minimal downtime when performed by trained professionals.

Indications

  • Global skin rejuvenation of the face, neck and décolleté.
  • Fine lines and early wrinkles (periorbital, perioral, forehead, cheeks).
  • Loss of skin elasticity and firmness associated with ageing and photoageing.
  • Thin, fragile or damaged skin with compromised barrier function.
  • Dull, dehydrated or tired-looking skin requiring biostimulatory revitalisation.
  • Enlarged pores and uneven skin texture.
  • Acne scars and other atrophic or textural scars as part of a broader treatment plan.
  • Post-procedural skin support (e.g. after lasers or peels), at the practitioner’s discretion.

Composition

  • Polynucleotides (PN / polydeoxyribonucleotide) 2% derived from salmon DNA (highly purified DNA fragments).
  • Buffered aqueous solution (phosphate buffer system; exact excipients according to official leaflet).
  • Water for injections.

Formulation

  • Injectable, transparent polynucleotide-based skin booster with PN 2% (medium-viscosity solution).
  • Non-cross-linked, non-particulate PN solution designed for dermal biostimulation rather than volumising filler effect.
  • Biocompatible DNA fragments similar to human DNA, promoting dermal regeneration and repair.
  • Sterile, pyrogen-controlled formulation supplied in pre-filled syringes for single-patient use.
  • Intended for intradermal injection by appropriately qualified medical professionals.

Packaging

  • Box containing 2 pre-filled syringes of 2 ml each (total 4 ml).
  • Each syringe contains Rejuran PN 2% polynucleotide solution derived from salmon DNA.
  • Typically used with 33G x 4 mm JBP nano needles (needle supply may vary by distributor).
  • Syringes (and needles where supplied) packaged in sterile blisters.
  • Outer carton printed with product name, composition, batch number and expiry date.
  • Instructions for use (IFU) / product leaflet and, where applicable, traceability labels for patient records.

Usage

  • For professional use only: treatment must be performed by licensed healthcare professionals trained in injectable skin boosters.
  • Perform a full medical history and skin assessment, including identification of indications and exclusion of contraindications; obtain informed consent before treatment.
  • Cleanse and disinfect the treatment area thoroughly with an appropriate antiseptic solution.
  • Inject Rejuran PN intradermally using micro-injection techniques (e.g. micro-papular, serial puncture, nappage) with a fine needle (commonly 30–33G), placing small aliquots evenly over the treatment area.
  • Typical treatment zones include the face (periorbital region, cheeks, forehead, nasolabial area), neck and décolleté; some practitioners may also treat the backs of the hands.
  • Use slow, controlled injections at an appropriate intradermal depth; aspirate cautiously where clinically appropriate and avoid high-pressure injections to minimise the risk of intravascular placement.
  • Standard protocols often recommend an initial course of 3–4 sessions spaced approximately 3–4 weeks apart, with dosage and intervals tailored to the patient’s skin condition and response.
  • After injection, gentle massage may be applied to distribute the product evenly and smooth injection papules if clinically appropriate.
  • Advise patients to avoid makeup on treated areas for several hours and to refrain from intense exercise, saunas, hot baths, sunbeds and excessive sun exposure for at least 24 hours or according to clinic protocol.
  • Reinforce the importance of sun protection and appropriate skincare to support and maintain treatment benefits.
  • Always follow the official instructions for use (IFU) and comply with local regulatory and professional guidelines.

Contraindications

  • Known hypersensitivity or allergy to polynucleotides, salmon-derived substances or any component of the formulation.
  • History of severe allergic reactions or anaphylaxis to injectable medical or cosmetic products.
  • Active skin infection, inflammation or dermatologic disease (bacterial, viral such as herpes, or fungal) at or near the proposed injection site.
  • Autoimmune disease or immunocompromised state unless, after careful evaluation, the treating physician judges that the benefits outweigh the risks.
  • Uncontrolled systemic disease or acute febrile illness.
  • Bleeding disorders, significant coagulation abnormalities or concurrent use of anticoagulant/antiplatelet therapy that markedly increases bleeding risk, unless appropriately assessed and managed by a physician.
  • Pregnancy and breastfeeding (generally not recommended due to insufficient safety data).
  • Patients under 18 years of age.
  • Presence of permanent fillers or foreign bodies in the same treatment area where interaction risk exists, unless specifically evaluated and approved by an experienced practitioner.
  • Any general contraindications to injectable aesthetic procedures as determined by the treating healthcare professional.

Adverse Effects

  • Common, usually mild and transient injection-site reactions such as redness (erythema), small papules, swelling or oedema, tenderness, itching or a sensation of tightness.
  • Localised pain or discomfort at injection points, typically resolving within 1–2 days.
  • Minor bruising or haematoma at injection sites.
  • Temporary skin sensitivity or mild irritation in treated areas.
  • Short-lived surface irregularities or slight asymmetry, which may improve spontaneously or require minor adjustment.
  • Occasional delayed inflammatory or hypersensitivity reactions (e.g. prolonged redness, swelling, induration or pruritus) that require medical evaluation and management.
  • Infection at the injection site if aseptic technique is not strictly followed.
  • As with any injectable treatment, very rare but serious complications such as inadvertent intravascular injection leading to tissue ischaemia or necrosis can occur and require immediate emergency management by an appropriately trained physician.
  • Any unexpected, persistent or severe adverse effect should be promptly assessed and treated according to clinical best practice and the product’s IFU.

Storage Conditions

  • Store according to manufacturer’s labelling, typically in a cool, dry place away from direct sunlight (often in the 2–25 °C range).
  • Do not freeze.
  • Keep the syringes in their original packaging until use to protect from light and contamination.
  • Avoid exposure to excessive heat or sudden temperature changes.
  • Do not use after the expiry date printed on the packaging.
  • Use only if the syringe, blister and outer packaging are intact and the solution appears clear and free from visible particles.
  • Single-use sterile product: do not resterilise and do not reuse any opened or partially used syringe.

Duration

Following a full course of around 3\u20134 sessions at 3\u20134 week intervals, improvements in hydration, elasticity, texture and fine lines are typically maintained for approximately 6\u201312 months, depending on age, skin condition, lifestyle and combination with other treatments. Maintenance or top-up sessions (for example every 6\u201312 months) are commonly recommended to sustain and enhance results.

Onset

Initial improvements in skin hydration and radiance may be noticeable within days to a few weeks after the first session, while more pronounced benefits in elasticity, fine lines, dermal thickness, pore size and overall texture develop progressively over 4\u20138 weeks and continue to build with subsequent treatments as collagen and extracellular-matrix regeneration occur.

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