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Rejuran S Skin Booster (1 × 1 ml)

Rejuran S Skin Booster (1 × 1 ml)

Rejuran

Skin booster
  • Distributed as a CE Marked polynucleotide Based dermal tissue stimulator / skin booster in various EU and UK aesthetic markets.
  • Manufactured in South Korea by PharmaResearch Co., Ltd. under medical Device quality Management systems for PN injectables.
  • Rejuran range (including Rejuran S) is noted in official and distributor materials as a dermal tissue reconstructive material composed of high Biocompatibility DNA fragments derived from wild salmon using DOT (DNA Optimising Technology).
Polynucleotide injectable for acne scars and skin texture regeneration

Description

Rejuran S Skin Booster (1 × 1 ml) is a high-concentration polynucleotide (PN) injectable designed to regenerate and smooth damaged skin, especially acne scars and textural irregularities. Formulated with purified salmon-derived polynucleotides, it stimulates fibroblasts, promotes collagen and elastin synthesis and supports tissue repair. Clinically designed to treat acne scars, fine lines, enlarged pores and uneven surface texture, Rejuran S targets the face, neck and décolletage to deliver visible rejuvenation through collagen remodelling and dermal regeneration. Unlike traditional volumising fillers, it acts primarily as a biostimulatory scar-repair and skin-quality booster.

Bnefits

  • Reduces the appearance of atrophic acne scars and other depressed scars.
  • Refines uneven skin texture and helps minimise enlarged pores.
  • Boosts collagen and elastin production for improved elasticity and firmness.
  • Diminishes fine lines and superficial wrinkles in treated areas.
  • Helps reduce pigmentation and post-inflammatory marks, promoting a more even skin tone.
  • Promotes deeper skin regeneration and dermal repair by providing a PN scaffold for tissue remodelling.
  • Improves overall skin quality, including smoothness, resilience and radiance.
  • Suitable for treatment of face (including cheeks, chin and perioral zone), neck and décolletage.
  • Can be used as a stand-alone scar treatment or combined with fractional lasers or other resurfacing procedures according to clinical judgment.

Indications

  • Atrophic acne scars (rolling, boxcar and selected ice-pick scars as clinically appropriate).
  • Other depressed or post-surgical scars on the face and selected body areas.
  • Uneven skin texture and surface irregularities.
  • Enlarged pores and rough skin surface.
  • Fine lines and early wrinkles in the lower face and peri-oral region.
  • Mild dyschromia and post-inflammatory pigmentation related to acne or scarring (as part of comprehensive treatment).
  • General improvement of skin quality on the face, neck and décolletage.

Composition

  • Polynucleotide (PN / polydeoxyribonucleotide) 2% (20 mg/ml) derived from salmon DNA.
  • Buffered aqueous solution (e.g. phosphate buffer; exact excipients according to official IFU).
  • Water for injections.

Formulation

  • High-concentration polynucleotide gel solution for intradermal injection.
  • Viscous, high-viscoelastic PN formulation designed to stay localised in depressed scars and irregularities.
  • Non-cross-linked polynucleotide biostimulator (not a traditional hyaluronic-acid volumising filler).
  • Transparent, sterile, pyrogen-controlled injectable product supplied in a pre-filled glass syringe or vial equivalent to 1 ml.
  • Intended for intradermal or very superficial subcutaneous administration by qualified medical professionals.

Packaging

  • 1 × 1 ml pre-filled syringe or vial per pack (as listed by LPG Clinics Wholesale and other distributors).
  • Typically used with a very fine needle (e.g. 30–33G; some suppliers specify 34G × 8 mm) for precision intradermal injections.
  • Sterile blister packaging for the syringe (and needle where supplied).
  • Outer carton with product name, batch number and expiry date.
  • Instructions for use (IFU) / product leaflet and, where applicable, traceability labels.

Usage

  • For professional use only: Rejuran S Skin Booster must be administered by licensed and appropriately trained healthcare professionals experienced with injectable scar and skin-booster treatments.
  • Conduct a full medical history and skin assessment to determine suitability, scar type and severity; rule out contraindications and obtain informed consent.
  • Cleanse the treatment area thoroughly and disinfect with appropriate antiseptic; topical anaesthetic cream may be applied as per clinic protocol and then removed before injection.
  • Inject small aliquots of Rejuran S intradermally at the base of atrophic scars and within texturally irregular areas using a fine needle (typically ~30–33G), employing serial puncture or micro-droplet technique.
  • For acne scars, place micro-deposits directly under and within each depressed scar to create a PN scaffold that supports collagen remodelling and scar elevation.
  • For broader texture or pore concerns on face, neck and décolletage, distribute micro-injections evenly over the treatment zone while keeping injections intradermal.
  • Standard clinical protocols commonly recommend 3–4 treatment sessions at intervals of about 3–4 weeks; number of sessions, dose per session and intervals should be tailored to the patient’s condition and response.
  • Rejuran S may be combined with fractional laser or radiofrequency resurfacing, subcision or other scar procedures in staged or same-session protocols as determined by the treating physician.
  • Inject slowly with low, controlled pressure; aspirate cautiously where appropriate and avoid intravascular injections, high-pressure boluses or placement into non-target tissues.
  • Post-treatment, mild massage around injection sites may be used if clinically appropriate to distribute the product; injection papules usually settle within a few days.
  • Advise patients to avoid makeup on treated areas for several hours and to avoid intense exercise, hot baths, saunas, sunbeds and direct sun exposure for at least 24 hours or as per clinic protocol.
  • Ensure patients follow post-care advice including gentle skincare and diligent photoprotection; schedule review and subsequent treatment sessions as indicated.
  • Always follow the official instructions for use (IFU) supplied with the product and comply with local regulatory and professional guidelines.

Contraindications

  • Known hypersensitivity or allergy to polynucleotides, salmon-derived substances or any excipient in the formulation.
  • History of severe allergic reactions or anaphylaxis to injectable medical or cosmetic products.
  • Active skin infection, inflammation or dermatologic disease (bacterial, viral such as herpes, or fungal) at or close to the intended injection area.
  • Autoimmune diseases or immunocompromised states unless, after careful evaluation, the treating physician judges that potential benefits outweigh risks.
  • Uncontrolled systemic illness or acute febrile conditions.
  • Bleeding disorders, significant coagulation abnormalities or concurrent anticoagulant/antiplatelet therapy that substantially increases bleeding risk, unless appropriately assessed and managed by a physician.
  • Pregnancy and breastfeeding (generally not recommended due to limited safety data).
  • Patients under 18 years of age.
  • Presence of permanent fillers or foreign bodies in the same area where there is a risk of interaction, unless evaluated and approved by an experienced practitioner.
  • Any general contraindication to injectable aesthetic procedures as determined by the treating healthcare professional.

Adverse Effects

  • Common, usually mild and transient injection-site reactions such as redness (erythema), small papules, mild swelling or oedema, tenderness, itching or a sensation of tightness.
  • Local pain or discomfort at injection sites, usually resolving within 1–2 days.
  • Minor bruising or haematoma at or near injection points.
  • Temporary skin sensitivity or mild irritation in treated areas.
  • Short-term surface irregularities or minor asymmetry that often improve spontaneously or with minor adjustment.
  • Occasional delayed inflammatory or hypersensitivity reactions such as prolonged redness, swelling, induration or pruritus, requiring medical evaluation and possible treatment.
  • Infection at the injection site if aseptic technique is not strictly observed.
  • Very rare but serious complications associated with injectable treatments, including inadvertent intravascular injection leading to tissue ischaemia or necrosis; such events require immediate emergency management by a suitably trained physician.
  • Any unexpected, persistent or severe adverse reaction should be promptly assessed and managed in line with clinical best practice and the official IFU.

Storage Conditions

  • Store according to manufacturer’s labelling, typically in a cool, dry place away from direct sunlight (often within the 2–25 °C range; check packaging for exact requirements).
  • Do not freeze.
  • Keep the syringe or vial in its original packaging until use to protect from light and contamination.
  • Avoid exposure to excessive heat or sudden temperature changes.
  • Do not use after the expiry date printed on the packaging.
  • Use only if the packaging is intact and the solution appears clear and free from visible particles.
  • Single-use sterile product: do not resterilise and do not reuse any opened or partially used syringe or vial.

Duration

A typical course consists of approximately 3\u20134 sessions spaced about 3\u20134 weeks apart. Improvements in scar depth, texture and overall skin quality often persist for around 9\u201312 months or longer after a completed course, depending on scar severity, individual healing response, lifestyle factors and any combination therapies. Maintenance or top-up treatments can be performed at clinician discretion to sustain results.

Onset

Initial softening and subtle lifting of depressed scars, as well as improvements in hydration and texture, may be noticeable within weeks of the first session. More pronounced benefits in acne scars, pore size, fine lines and overall surface smoothness typically develop progressively over 4\u20138 weeks and continue to improve with subsequent sessions as collagen remodelling and tissue regeneration occur.

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