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E45 Cream 50g

E45 Cream 50g

E45

Medicinal emollient cream
  • UK licensed medicine (E45 Cream) with a Marketing Authorisation issued to Karo Pharma AB.
  • Classified under ATC code D02AC (emollients and protectives, soft paraffin and fat products).
Dermatological cream for dry skin conditions

Description

E45 Cream 50g is a perfume-free, non-greasy emollient cream clinically proven to treat and soothe dry, itching, flaking, chapped, rough and calloused skin, as well as sunburn and detergent hands. It contains a triple-active formula of white soft paraffin, light liquid paraffin and hypoallergenic anhydrous lanolin (Medilan) that softens the skin, restores the moisture barrier and helps prevent further water loss. E45 Cream is recommended as an adjunctive treatment for more serious dry skin conditions such as eczema, dermatitis, ichthyosis and certain dry cases of psoriasis, and can be used daily by adults, the elderly, children and infants over 1 month of age.

Bnefits

  • Clinically proven to treat and soothe dry, itchy, flaky, chapped and rough skin.
  • Provides relief for sunburn and detergent-damaged hands.
  • Effective adjunctive treatment for eczema, dermatitis, ichthyosis and certain dry cases of psoriasis.
  • Triple-active emollient formula (white soft paraffin, light liquid paraffin, anhydrous lanolin) helps restore and protect the skin barrier.
  • Non-greasy, easily absorbed cream that leaves skin feeling soft, comfortable and relieved.
  • Perfume-free and dermatologically tested, suitable for sensitive skin.
  • Suitable for the whole family, including infants over 1 month.
  • Can be used on large body areas as a general moisturiser or targeted to particularly dry patches.

Indications

  • Symptomatic relief of dry skin conditions where an emollient is indicated.
  • Flaking, chapped or rough skin.
  • Dry, itchy, or flaky skin (including “detergent hands”).
  • Ichthyosis.
  • Traumatic dermatitis, including so-called “housewives’ dermatitis”.
  • Dry stages of eczema.
  • Certain dry cases of psoriasis (as emollient adjunctive therapy).
  • Sunburn (mild to moderate, unbroken skin).

Composition

  • White soft paraffin 14.5% w/w
  • Light liquid paraffin 12.6% w/w
  • Anhydrous lanolin (Medilan) 1.0% w/w
  • Glyceryl monostearate
  • Cetyl alcohol
  • Sodium cetostearyl sulphate
  • Carbomer
  • Methyl hydroxybenzoate (E218)
  • Propyl hydroxybenzoate (E216)
  • Sodium hydroxide
  • Citric acid monohydrate
  • Purified water

Formulation

  • Topical oil-in-water emollient cream.
  • Triple-active paraffin/lanolin base for occlusive and moisturising effect.
  • Perfume-free, non-greasy, white dermatological cream.

Packaging

  • 50 g plastic tube of E45 Cream in an outer carton, suitable for home and travel use.
  • Over-the-counter medicinal product available in pharmacies and medical supply outlets.

Usage

  • For adults, the elderly, children and infants over 1 month: apply to the affected area two or three times daily, or as often as required.
  • Apply in a thin to generous layer and massage gently into the skin until absorbed.
  • Can be used on the body, hands and face, avoiding the eyes and mucous membranes.
  • For external use only: do not swallow and do not apply inside the mouth, inner nose, genital area or on broken / bleeding skin.
  • If using with other topical medicines, apply as directed by a healthcare professional, leaving sufficient time between applications.
  • If dryness or irritation persists or worsens, consult a doctor or pharmacist.

Contraindications

  • Known hypersensitivity or allergy to white soft paraffin, light liquid paraffin, anhydrous lanolin (Medilan) or any of the excipients (including cetyl alcohol, methyl hydroxybenzoate E218, propyl hydroxybenzoate E216).
  • Do not apply to broken, actively bleeding or acutely infected skin.
  • Do not apply to mucous membranes (e.g. inside mouth, inner nose, genital area) or to the eyes.
  • Use with caution in individuals with known sensitivity to lanolin or parabens.
  • Not recommended for application to the breast area during breastfeeding.

Adverse Effects

  • Occasional hypersensitivity reactions such as allergic skin rash or irritation.
  • Local skin reactions including contact dermatitis (often related to cetyl alcohol or parabens).
  • Very rare cases of acneiform eruptions or folliculitis with prolonged heavy use of paraffin-based emollients.
  • Paraffin-containing products can soak into clothing and bedding and significantly increase flammability; if exposed to naked flames or lit cigarettes, there is a risk of serious burns.
  • Very rare risk of lipoid pneumonia if significant quantities of paraffin-based product are inhaled or aspirated (for example if misused near the nose in infants).

Storage Conditions

  • Store below 25°C in a dry place.
  • Keep the tube tightly closed when not in use.
  • Keep out of the sight and reach of children.
  • For external use only.
  • Do not use after the expiry date printed on the packaging.
  • Avoid smoking or going near naked flames when using this product; clothing, bedding, dressings and other fabrics in contact with the cream are more easily ignited. Change and wash these items regularly to reduce build-up, although washing may not remove all residues.

Duration

Use as often and for as long as needed to control dry skin symptoms; suitable for long-term daily use as a maintenance emollient unless otherwise advised by a healthcare professional.

Onset

Soothing and softening effects are typically felt within minutes of application as the non-greasy cream is quickly absorbed; continued regular use improves and maintains skin hydration over days to weeks.

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