Crystal Healer PN 2.5% (2.5 mL pre Filled syringe)

Crystal Healer

Aesthetic injectable / skin booster

Polynucleotide (PN) skin-booster injection

Manufactured by Koru Pharma, a registered aesthetics Pharma company, under regulatory standards applicable in South Korea and export markets.
Distributed through licensed aesthetic and mesotherapy product suppliers and intended for professional use only.

Manufactured by Koru Pharma, a registered aesthetics Pharma company, under regulatory standards applicable in South Korea and export markets.
Distributed through licensed aesthetic and mesotherapy product suppliers and intended for professional use only.

Polynucleotide (PN) skin-booster injection

Description

Crystal Healer PN 2.5% is a high-concentration polynucleotide (PN) skin-booster injectable designed to promote skin regeneration, collagen synthesis, improved elasticity and skin quality restoration. Supplied as a pre-filled 2.5 mL sterile syringe for professional aesthetic use, it aims at rejuvenating skin at the cellular level — reducing fine lines, improving texture, and supporting dermal extracellular matrix repair.

Bnefits

High concentration (2.5%) of purified polynucleotides (PN) for strong regenerative potential.
Stimulates fibroblast activity, collagen and elastin synthesis for improved skin elasticity, firmness and volume.
Supports extracellular matrix (ECM) renewal, enhancing dermal structural integrity and skin resilience.
Helps reduce fine lines, wrinkles and improves skin texture and density.
May improve skin hydration, barrier function and balance sebum production, leading to more even, healthier-looking skin.
Potential to improve post-acne scarring, stretch marks, enlarged pores and other signs of skin damage or aging.

Indications

Chronological and photo-ageing (fine lines, wrinkles, loss of elasticity, decreased skin density).
Loss of skin elasticity and firmness.
Post-acne or post-inflammatory dermal changes, scars and cicatricial skin damage.
Stretch marks, enlarged pores and uneven skin texture.
Skin areas with water imbalance (dehydrated skin) needing ECM support and hydration.
Patients desiring aesthetic rejuvenation, skin “bio-revitalisation”, improved glow, softness and overall skin quality improvement.

Composition

Sodium Polynucleotide (PN) — 25 mg/mL (2.5%) purified polynucleotides.
Phosphate-buffered saline (PBS) as solvent/carrier.
Lidocaine hydrochloride (as anaesthetic component to minimize injection discomfort).

Formulation

Sterile pre-filled syringe containing 2.5 mL PN solution (2.5% PN) for intradermal/subcutaneous injection as a skin booster.
Clear, low-viscosity injectable solution suitable for mesotherapy / skin-booster protocols.
Intended for professional use by qualified medical aesthetic practitioners.

Packaging

1 box containing 1 sterile pre-filled syringe of 2.5 mL PN solution.
Syringe individually sealed and intended for single use only.
Packaging labelled with PN concentration, volume, lot/expiry details and usage instructions (for professionals).

Usage

Must be administered only by trained and certified medical aesthetic professionals.
Injection area should be cleansed and prepared under aseptic conditions prior to application.
Inject intradermally or subcutaneously into target skin areas (face, neck, décolleté, hands, other suitable regions) according to a mesotherapy / skin-booster protocol, dose and depth to be chosen by clinician based on individual skin condition.
Recommend a series of sessions: often 3–4 treatments spaced 3–4 weeks apart for optimal collagen and ECM stimulation, followed by maintenance treatments as advised by the practitioner.
Post-injection care: avoid excessive sun exposure, vigorous activity or skin irritation for recommended period; follow practitioner's guidance for aftercare. (Typical of PN/skin-booster treatments.)

Contraindications

Not for use in patients with known hypersensitivity or allergy to polynucleotides, lidocaine, or any component of the formulation.
Not recommended for use in individuals with active skin infections, dermatitis, open wounds, inflamed or compromised skin at the injection site.
Not suitable for patients with autoimmune disorders or certain systemic conditions unless cleared by a physician (common precaution for injectable skin boosters).
Use only in licensed medical settings by qualified professionals; not for self-injection or unqualified administration.

Adverse Effects

Transient injection-site reactions such as redness, swelling, mild bruising or tenderness.
Temporary mild discomfort or burning due to lidocaine; low but possible risk of allergic or hypersensitivity reactions to PN or other components.
Possible formation of small papules or unevenness if injection technique or depth is incorrect — underscores need for professional administration. (Common with mesotherapy/skin boosters.)
Risk of infection or other complications if aseptic technique is not properly maintained during injection and post-care.

Storage Conditions

Store unopened syringes in a cool, dry place, protected from direct sunlight and heat as per manufacturer instructions.
Preferably store refrigerated or under controlled room temperature depending on distributor’s guidance (check packaging).
Do not freeze. Use before the expiry date. Keep out of reach of children. Ensure sterility until point of use.

Duration

Not fixed; each session is a single injection visit. Visible skin-quality changes may accumulate over a series of sessions (e.g. 3\u20134 treatments over several weeks) with long-term maintenance as per practitioner\u2019s protocol.

Onset

Initial improvements in skin texture, hydration and glow may be noticeable within 2\u20134 weeks; collagen and elasticity improvements typically develop over several weeks to months after serial treatments.