Manufactured by Dongkook Pharmaceutical Co., Ltd., a South Korean pharmaceutical company operating under Korean MFDS pharmaceutical and quality regulations.
Produced under GMP Compliant conditions for sterile injectable products.
Distributed internationally as an injectable sodium hyaluronate skin booster; classification (drug vs. device vs. cosmetic injectable) may vary by jurisdiction and is subject to local regulatory frameworks.
Manufactured by Dongkook Pharmaceutical Co., Ltd., a South Korean pharmaceutical company operating under Korean MFDS pharmaceutical and quality regulations.
Produced under GMP Compliant conditions for sterile injectable products.
Distributed internationally as an injectable sodium hyaluronate skin booster; classification (drug vs. device vs. cosmetic injectable) may vary by jurisdiction and is subject to local regulatory frameworks.
Intended exclusively for professional use in clinical or aesthetic practice settings, in accordance with local laws and professional guidelines.
Description
Hyaron is an injectable skin booster based on non-stabilised (non-crosslinked) hyaluronic acid in the form of sodium hyaluronate 25 mg/2.5 ml. Developed by Dongkook Pharmaceutical in South Korea, it is a mesotherapy-style bio-revitalisation product designed to deliver deep, long-lasting hydration, improve skin tone and texture and stimulate the skin’s natural extracellular matrix components. Supplied in 2.5 ml prefilled syringes, Hyaron is injected into the superficial dermis to restore moisture levels, increase elasticity and provide a smoother, more radiant and youthful-looking complexion. Its smooth, low-viscosity gel integrates evenly, helping to reduce fine lines, skin imperfections and pigmentation while promoting collagen and elastin synthesis. Aesthetic results typically last around 6–12 months, depending on the individual and treatment protocol.
Bnefits
Provides deep hydration across all skin layers by replenishing sodium hyaluronate in the superficial and upper dermis.
Enhances skin tone and texture for a more youthful, radiant appearance.
Stimulates the skin’s natural production of key extracellular matrix components, including collagen and elastin, via fibroblast activation.
Offers quick and effective correction of age-related skin concerns such as dryness, fine lines and early wrinkles.
Helps reduce skin imperfections, including acne scars, rosacea-related textural issues and certain forms of pigmentation, when used in appropriate protocols.
Delivers long-lasting results thanks to the high concentration and viscosity of the gel, with effects often maintained for 6–12 months.
Safe and generally well tolerated when used by trained professionals, with low allergenic potential due to non-animal, highly purified sodium hyaluronate.
Improves overall skin quality by increasing firmness, elasticity and brightness, contributing to a ‘glass skin’ effect.
Non-crosslinked formulation offers smooth flowability and even distribution, making it suitable for fine lines as well as general skin quality improvement.
Indications
Bio-revitalisation and intensive hydration of the face, neck and other suitable areas.
Improvement of overall skin quality, including tone, texture and elasticity.
Correction of age-related skin changes such as fine lines, early wrinkles and loss of turgor.
Dull, rough or dehydrated skin with large pores or uneven texture.
Adjunctive treatment to help reduce the appearance of acne scars and post-inflammatory textural changes, in suitable patients.
Supportive treatment for patients with rosacea-prone or sensitive skin where hydration and barrier support are indicated (under professional guidance).
Reduction of certain benign pigmentary irregularities and uneven complexion when combined with appropriate skincare and sun protection.
Non-surgical rejuvenation for patients seeking improved skin hydration and glow without volume-heavy fillers.
Composition
Active ingredient: Sodium hyaluronate 25 mg/2.5 ml (10 mg/ml).
Sodium chloride approximately 17.0 mg per 2.5 ml syringe.
Monobasic sodium phosphate (e.g. monobasic sodium phosphate dihydrate) approximately 1.2 mg per 2.5 ml syringe.
Water for injection q.s. to 2.5 ml.
Non-crosslinked, non-stabilised hyaluronic acid in the form of sodium hyaluronate; non-animal origin, highly purified.
Formulation
Non-crosslinked (non-stabilised) sodium hyaluronate gel for intradermal injection.
Clear, low-to-medium viscosity, monophasic solution/gel designed for smooth flow through fine needles (commonly 30G 1/2").
Concentration: sodium hyaluronate 25 mg per 2.5 ml prefilled syringe (10 mg/ml).
Sterile, apyrogenic and isotonic solution buffered with sodium chloride and sodium phosphate.
Biocompatible and biodegradable, gradually resorbed by the skin over several months.
Intended for mesotherapy-style bio-revitalisation rather than structural volumising filler use.
Packaging
Standard aesthetic packs: boxes typically contain 10 prefilled syringes, each with 2.5 ml of Hyaron (10 x 2.5 ml).
Single-syringe presentations (1 x 2.5 ml) offered by some distributors for clinic use and smaller treatment volumes.
Each syringe supplied sterile, often with 30G x 1/2" needles recommended or included depending on supplier.
Outer carton labelled with product name (Hyaron Prefilled Inj / Hyaron Skin Booster), active ingredient (sodium hyaluronate 25 mg/2.5 ml), batch number and expiry date.
Pack insert with instructions for use and technical information provided by the manufacturer or importer.
Usage
For professional use only: Hyaron must be administered by qualified healthcare professionals trained in intradermal injection and mesotherapy techniques.
Cleanse and disinfect the treatment area thoroughly; apply topical anaesthetic if required according to clinic protocol and patient comfort.
Inject into the superficial to upper dermis (around 1 mm depth) using a fine needle, commonly 30G 1/2", employing micro-papule, nappage or mesotherapy techniques.
Typical treatment protocols include a course of 4–6 sessions spaced approximately 7–14 days apart, or three sessions at monthly intervals, depending on the practitioner’s protocol and patient needs.
Per session, small aliquots are injected evenly across the treatment area (e.g. full face, neck, or targeted zones) to create uniform hydration and bio-revitalisation.
After injection, light massage may be used to distribute the product if needed, taking care not to over-compress the treated areas.
Advise patients to avoid makeup on treated areas for several hours, and to refrain from strenuous exercise, alcohol, saunas, and strong sun or heat exposure for 24–48 hours.
Recommend daily broad-spectrum sunscreen and supportive skincare to optimise results and protect against photoageing and pigmentation.
Maintenance treatments can be scheduled every 6–12 months or as clinically indicated based on skin condition and patient goals.
Practitioners must have appropriate emergency equipment and protocols in place, including readiness to manage hypersensitivity or vascular events, even though the product is non-crosslinked.
Contraindications
Known hypersensitivity or allergy to sodium hyaluronate, hyaluronic acid, or any excipients in the formulation.
Presence of active skin infections, inflammatory lesions or dermatologic conditions (e.g. active herpes, severe acne, dermatitis) at or near the intended injection sites.
History of severe allergic reactions or anaphylaxis to injectable products or hyaluronic acid-based treatments.
Autoimmune diseases or serious systemic illnesses where intradermal injections are considered unsafe by the treating physician.
Pregnancy and breastfeeding, as safety has not been established and aesthetic injectables are generally avoided.
Tendency to hypertrophic or keloid scarring in the treatment area, unless carefully assessed and justified.
Recent aggressive cosmetic procedures (deep chemical peels, ablative lasers, dermabrasion) in the treatment area without adequate healing time.
Use in patients under 18 years of age, or outside local regulatory and professional guidelines for injectable aesthetic treatments.
Adverse Effects
Common transient injection-site reactions such as redness, swelling, tenderness, itching, mild pain or bruising.
Small papules or bumps at injection sites that usually resolve spontaneously over a few days as the product is absorbed and distributed.
Temporary mild asymmetry or unevenness if injections are not perfectly uniform, typically manageable with subsequent sessions.
Occasional prolonged swelling or local inflammatory reactions, requiring clinical evaluation and supportive care if persistent.
Rare risk of infection at injection sites if aseptic technique or aftercare is inadequate.
Although non-crosslinked and low-viscosity, as with any injectable there is a very rare risk of inadvertent intravascular injection leading to vascular compromise; practitioners must follow safe injection practices and be prepared to manage complications.
Very rare hypersensitivity or allergic-type reactions to hyaluronic acid or excipients.
Storage Conditions
Store according to the manufacturer’s instructions, typically at controlled room temperature (approximately 2–25°C); some distributors specify refrigerated storage (2–8°C), so local pack guidance should always be followed.
Protect from direct sunlight and excessive heat; do not freeze.
Keep syringes in their original blister and outer carton until use to maintain sterility and traceability.
Do not use after the expiry date printed on the packaging.
Do not use if the syringe, blister or outer packaging is damaged or shows signs of compromised sterility.
Duration
Aesthetic and skin-quality improvements typically last around 6\u201312 months, with many sources citing approximately 6\u20139 months for hydration and up to 12 months for overall effect, depending on patient age, skin condition, lifestyle and maintenance treatments.
Onset
Initial improvement in hydration and skin plumpness is often visible within days of the first session, with cumulative benefits in tone, texture and elasticity developing over the course of multiple treatments and continuing to evolve over several weeks.
