Promoitalia Nucleoskin Topic 5 x 3 ml
Promoitalia
Mesotherapy skin boosterTopical polynucleotide (PDRN) cosmetic booster serum for microneedling
Certifications
- Professional cosmetic booster serum (not classified or marketed as a medicinal product)
- Intended for use by trained professionals in accordance with Promoitalia protocols and local cosmetic treatment regulations
- Professional cosmetic booster serum (not classified or marketed as a medicinal product)
- Intended for use by trained professionals in accordance with Promoitalia protocols and local cosmetic treatment regulations
Topical polynucleotide (PDRN) cosmetic booster serum for microneedling
Description
Promoitalia Nucleoskin Topic is a professional cosmetic booster serum formulated as a bio-restructuring solution for face and body. It combines a high concentration of biologically derived PDRN (polydeoxyribonucleotides) with cross-linked hyaluronic acid and glutathione. Designed for use with microneedling devices, dermarollers or Hyaluron Pen by trained professionals, it provides a liquid lifting effect, plumping and filling of fine lines and skin depressions, deep hydration and strong antioxidant protection. The cocktail promotes skin bio-regeneration at dermal and deeper levels, improving firmness, elasticity, texture and overall radiance, and is particularly suited to skin exposed to oxidative stress (smokers, pollution, pharmacological treatments).
Bnefits
- Liquid lifting effect through PDRN-mediated stimulation of skin rejuvenation and tissue toning
- Plumping and slight filling effect that reduces wrinkles and small skin depressions
- Powerful antioxidant action from glutathione, helping defend skin against free radicals
- Deep and long-lasting hydration via hyaluronic acid and polynucleotide water-binding properties
- Biorestructuring of the deep dermis, supporting collagen production and dermal matrix renewal
- Improves skin elasticity, firmness and overall texture
- Helps reduce the appearance of fine lines, periocular wrinkles and small depressed scars
- Enhances skin radiance and counteracts dull, tired-looking skin due to oxidative stress and environmental damage
- Indicated as a supportive treatment pre- and post-procedures such as blepharoplasty, lifting and resurfacing laser (when used according to protocol)
Indications
- Bio-restructuring and rejuvenation of photoaged and chronically aged facial skin
- Fine lines and superficial wrinkles on face, neck and décolletage
- Periocular wrinkles and small depressed scars
- Loss of firmness, elasticity and skin tone
- Dull, devitalised skin subjected to strong oxidative stress (e.g. smokers, high pollution exposure, certain pharmacological treatments, occupational exposure to oxidising agents)
- Skin needing deep hydration, plumping and overall quality improvement on face and selected body areas
Composition
- Biologically derived PDRN (polydeoxyribonucleotides) 2% with high molecular weight (approximately 2500 kDa)
- Hyaluronic acid 10 mg/ml, cross-linked with BDDE (slightly cross-linked, low concentration)
- Glutathione 2 mg/ml
- Sterile cosmetic solution base suitable for professional topical / transdermal application
Formulation
- Professional cosmetic bio-restructuring solution for topical use with microneedling, dermaroller or Hyaluron Pen
- High-molecular-weight PDRN 2% for dermal bio-regeneration
- Low-concentration, slightly cross-linked hyaluronic acid 10 mg/ml for filling and hydrating effect
- Glutathione 2 mg/ml as an antioxidant component
- Viscous liquid formulation supplied in sterile glass vials (3 ml each), non-pyrogenic, single-patient use
Packaging
- Outer carton containing 5 sterile glass vials
- Each vial contains 3 ml of Nucleoskin Topic solution (total 15 ml per box)
- Product leaflet with usage information and protocol guidance
- Batch and traceability information printed on vials and outer carton
Usage
- For professional use only; must be applied by trained medical or aesthetic practitioners experienced with microneedling/mesotherapy techniques.
- Cleanse and disinfect the treatment area thoroughly before application and maintain strict aseptic technique throughout the procedure.
- Apply Nucleoskin Topic using a dermapen, dermaroller, Hyaluron Pen or similar professional device according to the official protocol and device manufacturer’s instructions.
- Face protocol (typical guidance): use approximately 1.5 ml per facial treatment, delivering about 0.025 ml per micro-application (around 60 micro-applications for a full face).
- Body protocol (typical guidance): use approximately 3 ml per session, with around 0.1 ml per application point on the selected body area.
- Periocular protocol (as per manufacturer training): dilute the product 1:1 with physiological saline (1 ml product + 1 ml saline) before treating the periocular area and use around 0.025 ml per application point.
- Recommended initial course: 4–6 sessions, usually one session every 20–25 days, adjusting number and frequency based on skin condition and practitioner assessment.
- After treatment, advise patients to avoid intense sun exposure, heat (sauna, steam), swimming pools and the application of potentially irritating cosmetics on treated areas for the period recommended by the practitioner.
- Monitor skin response between sessions and adapt the protocol (depth, volume, interval) to the individual’s tolerance and clinical results.
Contraindications
- Known hypersensitivity or allergy to PDRN, hyaluronic acid, glutathione or any other component of the formulation
- Active skin infections, inflammatory dermatoses or open lesions at the intended treatment area
- Severe skin irritation, erythema or compromised skin barrier in the treatment zone
- History of severe allergic reactions or anaphylaxis to cosmetic or mesotherapy products with similar ingredients
- Use in pregnant or breastfeeding individuals is not recommended unless specifically evaluated and approved by a physician, due to lack of sufficient safety data
- Any other contraindication based on professional judgement and local regulations regarding cosmetic microneedling/mesotherapy procedures
Adverse Effects
- Transient redness, mild swelling or warmth at treated sites immediately after microneedling or application
- Temporary skin sensitivity or tightness in the treated area
- Mild pinpoint bleeding, micro-crusting or flaking related to microneedling technique
- Occasional bruising in areas treated more intensively or in individuals with fragile capillaries
- Although serious adverse effects are not commonly reported, any persistent irritation, signs of infection or unexpected reaction should be evaluated by a healthcare professional and treatment discontinued if necessary
Storage Conditions
- Store in a cool, dry place away from direct sunlight and heat sources.
- Recommended storage temperature: typically below 25–30°C as per cosmetic product norms, following any specific guidance on the outer carton.
- Do not freeze.
- Keep vials in their original packaging until use to maintain product integrity and protect from light.
- Use each vial in accordance with shelf life and discard any unused product in line with local regulations.
Duration
A typical initial course consists of 4\u20136 treatment sessions performed every 20\u201325 days; overall treatment duration is usually around 2\u20134 months, with maintenance sessions scheduled according to the practitioner\u2019s clinical judgement and the patient\u2019s skin response.
Onset
Early improvements in hydration and radiance can appear within the first few sessions, with more evident lifting, plumping and texture benefits generally observed after completion of the initial treatment course (several weeks).
