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Revofil Plus 2×1ml

Revofil Plus 2×1ml

Revofil

Dermal filler (medical device)
  • CE Marked hyaluronic acid dermal filler (CE Certified for mid To Deep dermal implantation for correction of moderate to severe wrinkles and folds)
  • Manufactured under ISO 13485 Compliant quality management system for medical devices
  • Produced according to Good Manufacturing Practice (GMP) standards
  • Non Animal Derived, biodegradable cross Linked hyaluronic acid with biomimetic peptide technology
Cross-linked hyaluronic acid dermal filler for medium-to-deep wrinkles, contouring and volumisation

Description

Revofil Plus 2×1ml is a next-generation, soft-touch dermal filler from Caregen that combines cross-linked hyaluronic acid (23 mg/ml) with an advanced dual biomimetic peptide complex. It is indicated for mid-to-deep dermal implantation to correct moderate to severe facial wrinkles and folds, restore facial volume and harmonise contours, and perform lip volumisation and contouring. The peptides (Oligopeptide-72 and Oligopeptide-50) enhance filler longevity by inhibiting hyaluronidase and stimulate collagen and elastin synthesis for biostimulatory skin rejuvenation. The 2×1 ml pack offers a versatile 2-in-1 solution for volumising and contouring areas such as cheeks, chin and jawline, delivering natural, sculpted and long-lasting results.

Bnefits

  • Dual-action 2-in-1 performance: volumising and contouring for comprehensive facial enhancement
  • Designed for mid-to-deep dermal implantation to treat moderate to severe wrinkles and folds
  • Restores facial volume and improves facial shape and harmony in areas like cheeks, chin and jawline
  • Soft-touch, cohesive gel for smooth injection, easy moulding and natural-looking results
  • Hyaluronic acid (23 mg/ml) provides immediate volume, hydration and wrinkle filling
  • Biomimetic peptides Oligopeptide-72 and Oligopeptide-50 prolong HA duration and support collagen and elastin production
  • Improves skin elasticity, firmness and structure while reducing visible signs of ageing
  • Suitable for lip volume enhancement and contouring for fuller, yet natural-looking lips
  • Long-lasting effects typically in the 10–12 month range, depending on area and patient factors

Indications

  • Moderate to severe facial wrinkles and folds
  • Medium-to-deep wrinkles around the face and neck
  • Nasolabial folds
  • Marionette lines
  • Forehead wrinkles
  • Wrinkles around the eyes and mouth (corners of the mouth, perioral area)
  • Tear troughs and under-eye hollows (depending on practitioner protocol)
  • Temporal hollows, upper and hollow cheeks
  • Jawline and chin contouring and small volume deficits
  • Lip augmentation and contouring (volume and definition)
  • General facial volume restoration and contour harmonisation

Composition

  • Cross-linked sodium hyaluronate (hyaluronic acid) 23 mg/ml, non-animal origin
  • Oligopeptide-72 (CG-Boostrin): inhibits hyaluronidase to prolong filler duration and provide more even HA degradation over time
  • Oligopeptide-50 (CG-Glamerin): stimulates collagen and elastin production and increases dermal hyaluronic acid for skin rejuvenation
  • Physiological buffer solution and standard injectable excipients
  • Biodegradable, highly stable, peptide-stabilised HA gel

Formulation

  • Soft-touch, cross-linked hyaluronic acid gel with biomimetic peptide complex
  • Designed as a combined biphasic/monophasic-like cohesive gel for optimal viscosity and elasticity
  • Mid-to-deep dermal filler for volume enhancement, contouring and wrinkle correction
  • Sterile, pyrogen-free, non-animal-derived HA formulation in prefilled syringes

Packaging

  • Box containing 2 × 1 ml prefilled glass syringes (total 2 ml)
  • Typically supplied with 4 × 27G 13 mm needles (2 needles per syringe, depending on market)
  • Each syringe provided in an individual sterile blister pack with Instructions for Use (IFU) and peel-off traceability labels

Usage

  • For professional use only; administration must be performed by suitably trained and qualified medical or aesthetic practitioners.
  • Indicated injection depth: mid-to-deep dermis for correction of moderate to severe wrinkles and folds, and soft-tissue augmentation.
  • Common treatment areas: nasolabial folds, marionette lines, forehead wrinkles, lines around eyes and mouth, tear troughs (as per protocol), cheeks, jawline, chin and lips.
  • Use strict aseptic technique: disinfect the treatment area and maintain sterility of syringe, needle and field at all times.
  • Attach the supplied 27G needle (or appropriate needle/cannula) and expel air before injection.
  • Inject slowly with minimal pressure using techniques such as linear threading, serial puncture, fanning or depot/bolus injections, tailored to the region and indication.
  • Avoid intravascular injection; aspirate according to clinic protocol and continuously monitor the patient for any signs of vascular compromise.
  • After injection, gently mould the filler with fingers if required to optimise shape, contour and surface smoothness.
  • Advise patients to avoid applying makeup to treated areas for several hours, and to avoid intense exercise, alcohol and exposure to extreme heat, cold or direct sunlight for at least 24 hours or as per clinic protocol.
  • Refer to the official Instructions for Use (IFU) included in the pack for full, manufacturer-approved guidance on indications, injection planes, techniques, contraindications and precautions.

Contraindications

  • Known hypersensitivity or allergy to hyaluronic acid, Oligopeptide-72, Oligopeptide-50 or any excipient in the formulation
  • History of severe or multiple allergies or anaphylactic reactions unless carefully assessed and cleared by a physician
  • Active skin infection, inflammation or dermatologic condition at or near the intended injection sites (e.g. herpes simplex, active acne, dermatitis)
  • Systemic infection or uncontrolled systemic disease where dermal filler treatment is inappropriate
  • Autoimmune disease or immunocompromised state, unless risk–benefit has been individually evaluated by the treating clinician
  • Pregnancy and breastfeeding (use is generally not recommended in the absence of robust safety data)
  • Known tendency to hypertrophic or keloid scarring or significantly impaired wound healing
  • Use in patients under 18 years of age
  • Planned injection into blood vessels or in high-risk vascular areas without appropriate expertise and safety measures

Adverse Effects

  • Common, usually transient injection-site reactions such as redness, swelling, tenderness, pain, bruising, itching or slight bleeding
  • Temporary nodules, papules, irregularities or asymmetry at or near the injection area, which may resolve spontaneously or require massage or minor corrective treatment
  • Localised infection or abscess formation if strict aseptic technique is not maintained
  • Immediate or delayed hypersensitivity or inflammatory reactions, including swelling, erythema and induration
  • Very rare but serious complications typical of hyaluronic acid fillers, such as vascular occlusion, tissue ischemia or necrosis, and visual disturbances or blindness if filler is inadvertently injected into a vessel, requiring prompt emergency management
  • Any persistent, unusual or severe adverse reaction should be rapidly evaluated and treated by a qualified medical professional

Storage Conditions

  • Store according to the temperature range indicated on the outer carton (commonly 2–25 °C).
  • Do not freeze.
  • Protect from direct sunlight and excessive heat or cold.
  • Keep syringes in their original sterile blister and carton until use to maintain sterility and traceability.
  • Do not use after the expiry date or if the packaging, blister or syringe appears damaged, previously opened or compromised.
  • Keep out of the reach of children.

Duration

Typical clinical duration is reported around 10\u201312 months, varying with treatment area, injection technique, patient metabolism, lifestyle and skin condition.

Onset

Visible improvement in volume and wrinkle filling is immediate after injection; optimal aesthetic results become apparent once initial post-treatment redness or swelling subsides over the following days.

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