Amoxicillin Sugar Free Suspension 250 mg/5 ml 100 ml
Amoxicillin
Prescription-only medicine (antibiotic)Oral suspension (sugar-free) amoxicillin
Certifications
- Licensed UK medicinal product under MHRA (POM) – sugar Free oral suspension authorised for dispensing.
- Manufactured in compliance with Good Manufacturing Practice (GMP) standards and distributed via authorised UK wholesalers/pharmacies under regulatory oversight.
- Licensed UK medicinal product under MHRA (POM) – sugar Free oral suspension authorised for dispensing.
- Manufactured in compliance with Good Manufacturing Practice (GMP) standards and distributed via authorised UK wholesalers/pharmacies under regulatory oversight.
Oral suspension (sugar-free) amoxicillin
Description
Amoxicillin Sugar-Free Suspension (250 mg/5 ml) is a prescription-only oral antibiotic suspension for wide use. Once reconstituted, each 5 ml dose contains 250 mg of amoxicillin (as amoxicillin trihydrate). The sugar-free formulation is designed for patients who require or prefer a sugar-free liquid antibiotic and for those unable to swallow tablets or capsules. It is indicated for the treatment of a broad spectrum of susceptible bacterial infections including respiratory, urinary, skin and soft tissue, ENT, and dental infections.
Bnefits
- Sugar-free formulation — suitable for patients needing sugar-free medication (e.g. diabetic patients, sugar-restricted diets)
- Liquid suspension allows easier administration for children and adults unable to swallow tablets or capsules
- Broad-spectrum antibiotic effective against many common bacterial pathogens (when susceptible) including those causing ENT, respiratory, urinary, skin, soft tissue and dental infections
- Flexible dosing based on weight/age or clinical need when prescribed by a qualified clinician
- Well-established safety profile and extensive clinical usage history for a range of bacterial infections globally
Indications
- Acute bacterial sinusitis, acute otitis media, acute streptococcal tonsillitis and pharyngitis
- Lower respiratory tract infections including acute exacerbations of chronic bronchitis and community-acquired pneumonia when caused by susceptible organisms
- Urinary tract infections including acute cystitis and pyelonephritis (in susceptible cases)
- Skin and soft tissue infections including wound infections and cellulitis (when caused by susceptible bacteria)
- Dental infections including dental abscesses, especially with spreading cellulitis or in combination with dental procedures
- Prophylaxis of bacterial endocarditis and prophylaxis before certain procedures where indicated (in susceptible patients)
Composition
- Amoxicillin trihydrate BP equivalent to 250 mg amoxicillin per 5 ml dose of reconstituted suspension
- Excipients include sorbitol (E420) as sweetener in sugar-free formulation, sodium benzoate (E211) preservative, sodium citrate, citric acid, flavouring agents (e.g. banana flavour), colloidal anhydrous silica, xanthan gum and other standard suspension excipients, depending on manufacturer batch.
- Free from sucrose (sugar-free), making it suitable for patients with sugar intake restrictions.
Formulation
- Powder for oral suspension (sugar-free) to be reconstituted with water to obtain 100 ml suspension.
- Oral antibiotic (beta-lactam aminopenicillin) intended for systemic antibacterial therapy when taken orally.
Packaging
- Bottle of 100 ml powder for oral suspension (unreconstituted) per pack (POM x1) as supplied in UK pharmacies/wholesalers.
- Outer carton with patient information leaflet (PIL) and instructions for reconstitution and use.
Usage
- Dispensed and reconstituted by a pharmacist according to the manufacturer’s instructions before first use.
- Shake well before each dose to ensure uniform suspension.
- Dosing to be determined by prescriber based on infection type, patient’s age/weight and renal function. Commonly given 3 times daily (every 8 hours) or as per prescription.
- Give with or without food; taking with food may reduce gastrointestinal upset in some patients.
- Use an oral syringe or medicine spoon for accurate measurement; do not use a kitchen teaspoon.
- Complete full prescribed course even if symptoms improve earlier, to avoid relapse or antibiotic resistance.
Contraindications
- Known hypersensitivity to amoxicillin, any penicillin or any component of the formulation (including sorbitol or preservatives)
- History of severe immediate hypersensitivity reaction (e.g. anaphylaxis or angioedema) to beta-lactam antibiotics such as penicillins or cephalosporins.
- Patients with hereditary fructose intolerance or other known intolerance to sorbitol (excipients), as sugar-free formulation contains sorbitol E420.
- Infections caused by bacteria resistant to amoxicillin; use only when susceptibility is confirmed or strongly suspected.
- Severe renal impairment may require dose adjustment; prescriber must evaluate renal function.
Adverse Effects
- Common: nausea, vomiting, diarrhoea, abdominal discomfort.
- Skin reactions: rash, urticaria, possible allergic reactions.
- Rare but serious: severe allergic reactions including anaphylaxis, angioedema, Stevens–Johnson syndrome or toxic epidermal necrolysis in susceptible individuals.
- Possible overgrowth of non-susceptible organisms (e.g. Candida) or altered gut flora, especially during prolonged use.
- Potential liver enzyme changes or hepatic disturbances (rare), reversible upon discontinuation.
- Risk of Clostridioides difficile–associated diarrhoea/colitis, particularly with extended use or in elderly patients.
Storage Conditions
- Store powder (unreconstituted) at room temperature (below 25°C) in original bottle until reconstitution.
- After reconstitution, store as directed by the pharmacist (often fridge 2–8 °C) and use within the period specified on the bottle label (commonly 7–14 days).
- Keep out of sight and reach of children.
- Do not use after expiry date printed on the packaging or if the bottle or contents appear damaged or contaminated.
Duration
Depends on the type and severity of infection; durations commonly range from 5 to 10 days for common infections, but may be longer as per prescriber\u2019s recommendation.
Onset
Symptomatic improvement often begins within a few days (e.g. 2\u20133 days), but full benefit and eradication of bacteria require completion of full treatment course.
