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Pabrinex (Generic) Vitamin C & B Injection IV 5 ml Pack of 6

Pabrinex (Generic) Vitamin C & B Injection IV 5 ml Pack of 6

Pabrinex

Medicinal Products
  • Authorised in the United Kingdom as Vitamin B&C Intravenous High Potency, Concentrate for Solution for Infusion, with marketing authorisation held by Grünenthal Limited (PL 21727/0116).
  • Listed on the electronic Medicines Compendium (emc) as Vitamin B&C Intravenous High Potency (formerly branded Pabrinex IV High Potency) with an up To Date Summary of Product Characteristics and Patient Information Leaflet.
  • Classified as a prescription Only medicine (POM) in the UK and subject to MHRA regulation and pharmacovigilance, including Yellow Card adverse event reporting.
  • Manufactured in accordance with Good Manufacturing Practice (GMP) for parenteral medicinal products.
  • ATC classification A11EB (multivitamins, parenteral preparations).
  • Supplied by GPhC Registered pharmacies such as AestheticsRx Pharma Ltd, which is regulated by the General Pharmaceutical Council (GPhC reg. no. 9012430).
Intravenous high-potency vitamin B and C concentrate for solution for infusion

Description

Pabrinex (Generic) Vitamin C & B Injection IV 5 ml Pack of 6 is a high-potency intravenous vitamin preparation containing water-soluble B-complex vitamins and vitamin C in concentrated form. It corresponds to the UK-licensed product Vitamin B&C Intravenous High Potency, Concentrate for Solution for Infusion, which is presented as pairs of 5 ml ampoules (No. 1 and No. 2) for dilution and intravenous infusion. Each pair provides thiamine (vitamin B1), riboflavin (B2), pyridoxine (B6), nicotinamide, and ascorbic acid (vitamin C), with added glucose. The product is used for rapid therapy of severe depletion or malabsorption of water-soluble vitamins B and C, particularly in clinical situations such as alcoholism (including risk of Wernicke’s encephalopathy), after acute infections, post-operatively, certain psychiatric states, and in patients on chronic intermittent haemodialysis. AestheticsRx Pharma supplies this generic Pabrinex IV pack (6 x 5 ml pairs) primarily for use in hospital and clinical environments, including aesthetic and wellness settings where IV vitamin therapy is prescribed, and it is always administered by a healthcare professional as a diluted intravenous infusion.

Bnefits

  • Provides rapid replacement of key water-soluble vitamins B and C in patients with severe depletion or malabsorption.
  • Supplies thiamine (vitamin B1), which is critical in preventing and treating Wernicke’s encephalopathy in patients with alcohol dependence or malnutrition.
  • Supports normal carbohydrate metabolism, energy production and nervous system function through high-dose vitamins B1, B2, B6 and nicotinamide.
  • Delivers a high dose of ascorbic acid (vitamin C), contributing to antioxidant protection, immune function and collagen synthesis.
  • Licensed for rapid therapy of severe vitamin B and C deficiencies in adults and children, with dosing regimens defined in the Summary of Product Characteristics.
  • Administered intravenously to bypass gastrointestinal absorption, making it suitable for patients with malabsorption, vomiting or reduced oral intake.
  • Concentrate for solution for infusion that can be diluted in standard IV fluids such as 0.9% sodium chloride or 5% glucose for 30-minute infusions.
  • Pack of multiple ampoule pairs (clinical multi-dose course) allows treatment over several days as per hospital protocols.
  • Used as part of standard hospital and guideline-based regimens for alcohol-related brain disease, refeeding risk and other deficiency states.
  • Generic ‘Vitamin B&C Intravenous High Potency’ presentation offers continuity of supply for clinicians familiar with Pabrinex IV regimens.

Indications

  • Rapid therapy of severe depletion or malabsorption of the water-soluble vitamins B and C in adults and children.
  • Particularly indicated in alcoholism, where severe depletion of thiamine can lead to Wernicke’s encephalopathy.
  • Use after acute infections where vitamin requirements or losses may be increased.
  • Use post-operatively, especially in patients with poor nutritional status or increased metabolic demand.
  • Use in certain psychiatric states where deficiencies of B and C vitamins may contribute to symptomatology.
  • Maintenance of vitamin B and C levels in patients on chronic intermittent haemodialysis.
  • Use in patients at risk of or with established malnutrition and malabsorption when oral supplementation is inadequate or impossible.
  • Commonly used (off-label in some protocols) in refeeding risk or refeeding syndrome contexts as part of hospital thiamine and micronutrient regimens, under specialist guidance.

Composition

  • Each presentation consists of a pair of 5 ml glass ampoules: Vitamin B&C No. 1 and Vitamin B&C No. 2.
  • Ampoule No. 1 (5 ml) contains: Thiamine hydrochloride (vitamin B1) 250 mg.
  • Ampoule No. 1 (5 ml) contains: Riboflavin (as riboflavin sodium phosphate, vitamin B2) 4 mg.
  • Ampoule No. 1 (5 ml) contains: Pyridoxine hydrochloride (vitamin B6) 50 mg.
  • Ampoule No. 2 (5 ml) contains: Ascorbic acid (vitamin C) 500 mg.
  • Ampoule No. 2 (5 ml) contains: Nicotinamide 160 mg.
  • Ampoule No. 2 (5 ml) contains: Glucose (as glucose monohydrate) 1000 mg.
  • Excipients with known effect: approximately 79 mg sodium per 1 pair of 5 ml ampoules (about 3.4 mmol sodium), equivalent to roughly 4% of the WHO recommended maximum daily intake of sodium for an adult.
  • Other excipients include edetic acid, sodium hydroxide (for pH adjustment) and water for injections.

Formulation

  • Pharmaceutical form: Concentrate for solution for infusion.
  • Parenteral vitamin preparation combining high doses of vitamins B1, B2, B6, nicotinamide and vitamin C with glucose.
  • Supplied as two separate 5 ml amber glass ampoules (No. 1 and No. 2) that must be used together as a pair.
  • Intended route of administration: intravenous infusion only, after dilution in a suitable IV infusion fluid.
  • ATC code: A11EB – Multivitamins, parenteral preparations.
  • Prescription-only medicine (POM) for use under medical supervision in hospital or clinical settings.

Packaging

  • Pack of 6 pairs of 5 ml amber Type I glass ampoules (6 x Ampoule No. 1 and 6 x Ampoule No. 2) for intravenous use.
  • Each ampoule pair provides a complete dose of high-potency vitamins B and C when diluted and infused according to the SmPC.
  • Ampoules are supplied in an outer carton to protect from light, labelled with product name, strength, batch number and expiry date.
  • Cartons may be labelled as Vitamin B&C Intravenous High Potency, Concentrate for Solution for Infusion (generic Pabrinex IV equivalent).
  • Intended for hospital pharmacies, clinics and registered prescribers; AestheticsRx Pharma lists the pack as “Pabrinex (Generic) Vitamin C & B Inj IV 5 ml Pack of 6”.

Usage

  • For intravenous use only; must not be given by any other route.
  • Pabrinex/Vitamin B&C Intravenous High Potency is administered by slow intravenous infusion after dilution, usually in a hospital or clinical setting.
  • The contents of Ampoule No. 1 and Ampoule No. 2 (equal volumes) are drawn up and added together to 50–100 ml of a compatible infusion fluid such as 0.9% sodium chloride or 5% glucose.
  • The diluted solution is infused intravenously over approximately 30 minutes.
  • Dosage and frequency depend on the indication and local hospital protocol; examples from the SmPC include: - Rapid therapy of severe depletion or malabsorption (e.g. in alcoholism and risk of Wernicke’s encephalopathy): typically 2–3 pairs of 5 ml ampoules diluted in 50–100 ml infusion solution and infused over 30 minutes every 8 hours, as determined by the physician. - Psychosis after narcosis or ECT, or toxicity after acute infections: usually 1 pair of ampoules diluted in 50–100 ml infusion solution, infused over 30 minutes twice daily for up to 7 days. - Haemodialysis: usually 1 pair of ampoules diluted in 50–100 ml infusion solution and infused over 30 minutes at the end of dialysis every two weeks.
  • Paediatric dosing (when indicated) is based on fractions of the adult dose (e.g. quarter, one-third, or half to two-thirds of the adult dose depending on age), as per the SmPC and specialist guidance.
  • The product must be diluted before use and visually inspected for particulate matter or discolouration; ampoules showing any defects should not be used.
  • Administration should be performed by healthcare professionals with access to facilities for managing anaphylaxis and other acute reactions.
  • Use as part of established protocols (for example, alcohol-related brain disease or refeeding risk) should follow local guideline dosing and treatment duration.
  • This product is prescription-only; AestheticsRx Pharma supplies it only to registered prescribers and practitioners, to be used under medical supervision.

Contraindications

  • Known hypersensitivity to any of the active substances (thiamine, riboflavin, pyridoxine, nicotinamide, ascorbic acid) or to any excipient in the formulation.
  • History of severe hypersensitivity or anaphylactic reaction to parenteral vitamin B or C preparations of similar composition.
  • Use in patients where intravenous infusion is contraindicated or clinically inappropriate (for example, severe circulatory overload) unless benefits clearly outweigh risks.
  • Caution in patients with known hyperoxaluria or a history of kidney stones, due to the vitamin C content, particularly with repeated dosing.
  • Caution in patients on controlled sodium diets because each pair of ampoules contains approximately 79 mg sodium.
  • Pregnancy and breastfeeding: no specific adverse effects have been reported at recommended doses when clinically indicated, but use should be based on a careful assessment of benefit versus risk and in accordance with the SmPC.
  • Any additional contraindications and special warnings as outlined in the current UK SmPC for Vitamin B&C Intravenous High Potency must be observed.

Adverse Effects

  • Hypersensitivity reactions, including rash, urticaria and, rarely, severe reactions such as anaphylaxis and anaphylactic shock.
  • Injection site reactions, including pain, swelling or inflammation at or around the site of infusion.
  • Vascular reactions such as hypotension (low blood pressure), particularly if infused too rapidly.
  • Nervous system effects such as paraesthesia (tingling or pins-and-needles sensations).
  • Flushing, warmth, or general feelings of malaise during or shortly after infusion in some patients.
  • Very rare or unknown-frequency reactions associated with rapid parenteral administration of high-dose vitamins, which may require interruption of infusion and appropriate management.
  • In general, adverse reactions are uncommon when the product is diluted and infused slowly over 30 minutes as recommended, and when facilities for the treatment of anaphylaxis are available.

Storage Conditions

  • Do not store above 25°C.
  • Keep the ampoules in the outer carton to protect from light.
  • Do not freeze.
  • From a microbiological point of view, once diluted in an infusion fluid the solution should preferably be used immediately. If not used immediately, in-use storage times and conditions (usually not more than 24 hours at 2–8°C, protected from light) are the responsibility of the user and must follow aseptic preparation standards.
  • Do not freeze diluted solutions.
  • Ampoules should be visually inspected before use and discarded if particulate matter, discolouration or damage is observed.
  • Store out of the sight and reach of children.
  • AestheticsRx Pharma supplies the product as a prescription hospital/clinic item; clinics should store it according to the SmPC (ambient, protected from light) and local medicines-management policies.

Duration

Treatment duration is determined by the underlying condition and clinical response. In rapid therapy of severe vitamin B and C depletion (for example, in alcoholism with risk of Wernicke\u2019s encephalopathy), Pabrinex/Vitamin B&C Intravenous High Potency is typically given for several days (for example, 2\u20133 pairs of ampoules every 8 hours for a defined period, or 1\u20132 pairs daily or twice daily for up to 5\u20137 days) before stepping down to oral thiamine and other vitamins. In haemodialysis patients, maintenance dosing may be continued every two weeks at the end of dialysis sessions. Overall duration is defined by hospital protocols and specialist judgement and is generally short to medium term, followed by ongoing oral supplementation once the acute deficiency has been corrected.

Onset

Onset of effect is rapid because the product is given intravenously. Plasma concentrations of vitamins B and C rise during and immediately after infusion, providing prompt correction of severe deficiencies. Clinical improvement in deficiency-related symptoms (for example, in Wernicke\u2019s risk, malnutrition or post-operative states) may be observed over hours to days, depending on severity and co-existing conditions.

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