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Prednisolone 5mg Tablets (28)

Prednisolone 5mg Tablets (28)

Generic

Prescription only medicine
  • UK Licensed prescription Only medicine (POM) containing prednisolone 5mg as active ingredient, authorised by the MHRA under one or more Marketing Authorisations held by UK generic manufacturers.
  • Manufactured in accordance with EU/UK Good Manufacturing Practice (GMP) for medicinal products.
  • Supplied by Teleta Pharma, which holds a UK Wholesale Distribution Authorisation [WDA(H)] and operates under Good Distribution Practice (GDP).
Oral corticosteroid tablets

Description

Prednisolone 5mg Tablets (28) are prescription-only oral corticosteroid tablets supplied as a 28-tablet pack of generic prednisolone 5mg. Prednisolone is a synthetic glucocorticoid used for its anti-inflammatory and immunosuppressive effects in a wide range of conditions, including allergic and inflammatory disorders, autoimmune diseases, respiratory conditions (such as asthma), certain skin diseases, inflammatory bowel disease and some blood and endocrine disorders. The tablets are intended for short- or long-term systemic therapy as directed by a prescriber, with dosage and treatment duration adjusted according to the underlying condition and patient response.

Bnefits

  • Provides potent systemic anti-inflammatory and immunosuppressive activity to control a wide range of inflammatory and autoimmune conditions.
  • Can rapidly reduce symptoms such as swelling, redness, pain and allergic reactions when appropriately dosed.
  • Oral tablet form allows flexible dosing regimens (once-daily, divided doses, or alternate-day therapy) tailored by the prescriber.
  • Often used as first-line or adjunctive therapy in acute exacerbations of asthma, severe allergies and inflammatory flares.
  • Generic prednisolone 5mg tablets are widely used, well-characterised and supported by extensive clinical experience.
  • Pack size of 28 tablets is convenient for many short courses or for initial treatment periods before review.

Indications

  • Allergic and anaphylactic conditions (e.g. severe asthma, drug hypersensitivity reactions, serum sickness, angioedema, anaphylaxis) as part of standard treatment regimens.
  • Rheumatic and musculoskeletal disorders (e.g. rheumatoid arthritis, polymyalgia rheumatica, certain inflammatory arthritides) when systemic corticosteroids are indicated.
  • Dermatological diseases (e.g. severe psoriasis, pemphigus, severe eczema and other serious inflammatory skin disorders) requiring systemic corticosteroid therapy.
  • Respiratory diseases such as bronchial asthma or COPD exacerbations where systemic corticosteroids are part of guideline-directed management.
  • Gastrointestinal inflammatory conditions (e.g. ulcerative colitis, Crohn’s disease) where systemic steroids are indicated.
  • Haematological and oncological conditions (e.g. certain leukaemias, lymphomas, autoimmune haemolytic anaemia, idiopathic thrombocytopenic purpura) as part of multi-drug regimens.
  • Endocrine disorders such as adrenocortical insufficiency (as a glucocorticoid component of replacement therapy, usually with a mineralocorticoid).
  • Other inflammatory and autoimmune diseases (e.g. systemic lupus erythematosus, vasculitides, mixed connective tissue disease) according to specialist guidance.
  • Prevention of organ transplant rejection and management of graft-versus-host reactions as part of immunosuppressive protocols, when prednisolone is chosen.

Composition

  • Active ingredient: Prednisolone 5 mg per tablet.
  • Typical excipients in UK generic prednisolone 5mg tablets may include lactose (as lactose monohydrate), maize starch or pregelatinised starch, stearic acid, talc and magnesium stearate; exact excipients depend on the specific licensed generic supplied.

Formulation

  • Solid oral dosage form: 5 mg prednisolone tablet for swallowing with water.
  • Tablets are usually white or off-white, round, with a break line and product identification depending on the specific generic manufacturer.
  • Formulated for systemic absorption of prednisolone after oral administration.

Packaging

  • Blister packs or strip packs containing 28 x 5mg tablets (Prednisolone 5mg Tablets BP or equivalent).
  • Outer carton with printed product name, strength, pack size, batch number and expiry date, plus regulatory labelling from the relevant MA holder.
  • Patient Information Leaflet (PIL) included in the pack, providing detailed instructions on use, contraindications, warnings and side effects.

Usage

  • Use only as prescribed by a doctor; do not self-medicate with prednisolone tablets without medical supervision.
  • Tablets are usually taken once daily in the morning after breakfast, or in divided doses, according to the prescriber’s instructions.
  • Swallow tablets whole with water; if a specific generic tablet is scored, it may be split to obtain lower doses only if advised by a healthcare professional.
  • Dosage varies widely depending on the condition being treated and may range from low maintenance doses (e.g. 5–10 mg daily) to higher doses in acute or severe disease; follow the prescribed dose exactly.
  • Do not stop taking prednisolone suddenly if you have been on it for more than a short course (e.g. longer than 1–2 weeks) unless your prescriber provides a tapering schedule; abrupt withdrawal can cause adrenal insufficiency and disease flare.
  • Attend regular medical reviews and blood tests if taking prednisolone long term to monitor for side effects such as changes in blood pressure, blood sugar, bone density and eye health.
  • If you miss a dose, take it as soon as you remember on the same day; if it is almost time for the next dose, skip the missed dose and follow your usual schedule. Do not double up doses.
  • Carry a steroid treatment card or equivalent if on long-term prednisolone, and inform healthcare providers, dentists and surgeons that you are taking a systemic corticosteroid.
  • Seek medical advice promptly if you become unwell with infection or severe stress (e.g. surgery, major illness) while on prednisolone, as dose adjustments may be needed.

Contraindications

  • Known hypersensitivity to prednisolone or any excipient in the specific tablet formulation supplied (e.g. lactose).
  • Systemic fungal infections where adequate antifungal therapy is not in place.
  • Use of live attenuated vaccines in patients receiving high-dose systemic corticosteroid therapy (risk of disseminated infection).
  • Prednisolone should generally not be used in untreated serious infections unless as part of a regimen where an appropriate antimicrobial is given and the benefit outweighs the risk.
  • Special caution (often relative contraindications requiring careful risk–benefit assessment and monitoring) in patients with: active or latent tuberculosis, peptic ulcer disease, severe osteoporosis, uncontrolled diabetes mellitus, uncontrolled hypertension, congestive heart failure, severe renal or hepatic impairment, glaucoma, cataracts, psychiatric history (e.g. steroid-induced psychosis), and in children or adolescents (due to risk of growth suppression).

Adverse Effects

  • Common or important systemic steroid adverse effects include: increased susceptibility to infections and masking of infection signs; weight gain and Cushingoid appearance; fluid retention, oedema and hypertension; mood changes (euphoria, depression, irritability), sleep disturbance; increased blood glucose or worsening of diabetes; muscle weakness and wasting; thinning of the skin, easy bruising, delayed wound healing and acne; osteoporosis, increased fracture risk and, in children, growth suppression; peptic ulcers and gastrointestinal bleeding; cataracts and glaucoma; menstrual irregularities; and adrenal suppression with risk of acute adrenal crisis if stopped abruptly after prolonged use.
  • Many adverse effects are dose- and duration-dependent; the lowest effective dose for the shortest possible time should be used, with regular monitoring during long-term therapy.

Storage Conditions

  • Store below 25°C or as indicated on the specific product packaging.
  • Keep the tablets in the original blister or container to protect from moisture and light.
  • Keep out of the sight and reach of children.
  • Do not use after the expiry date stated on the pack; return unused or expired tablets to a pharmacy for safe disposal.

Duration

Highly variable and determined by the prescribing clinician. Prednisolone 5mg tablets may be used for short courses (e.g. a few days to a couple of weeks) in acute conditions, tapering regimens over several weeks, or long-term maintenance therapy in chronic disorders, with duration regularly reviewed and minimised where possible.

Onset

Clinical improvement in many inflammatory and allergic conditions is often seen within hours to a few days after starting appropriate doses; full benefit and disease control may take longer depending on the indication and disease severity.

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