Manufactured by WEDERM Co., Ltd., a Korean medical Aesthetics manufacturer specialising in skin boosters and dermal products.
Developed under Korean medical aesthetics quality and safety frameworks; exported internationally as a professional Use injectable PN skin booster.
Part of the AETER / AeterDerm product family, which includes CE Certified PN eye treatments in some markets; practitioners should verify the exact regulatory classification and approvals of the PRO 6% version in their own country before use.
Manufactured by WEDERM Co., Ltd., a Korean medical Aesthetics manufacturer specialising in skin boosters and dermal products.
Developed under Korean medical aesthetics quality and safety frameworks; exported internationally as a professional Use injectable PN skin booster.
Part of the AETER / AeterDerm product family, which includes CE Certified PN eye treatments in some markets; practitioners should verify the exact regulatory classification and approvals of the PRO 6% version in their own country before use.
Produced using high Purity, medical Grade salmon Derived polynucleotides with biocompatibility testing typical for PN Based injectables.
Description
Puri Eyes Pro 6mg Polynucleotide 3x Stronger 1.1ml is the high-concentration version of the AETER Puri Eyes under-eye skin booster, engineered specifically for advanced periocular rejuvenation. Using medical-grade sodium polynucleotide (PN) at a 6% concentration (approximately three times stronger than the standard 2% Puri Eyes formulation), this injectable solution targets the delicate under-eye area to improve skin quality, reduce dark circles, smooth wrinkles and fine lines, and restore elasticity. The PN chains, derived from purified salmon DNA, act as powerful biostimulators, activating fibroblasts, enhancing collagen and elastin synthesis, and supporting dermal regeneration. Combined with hyaluronic acid and a buffered aqueous base, Puri Eyes Pro provides deep hydration, structural support and visible lifting while maintaining a natural, non-volumising result suitable for subtle, refined eye-area rejuvenation.
Bnefits
High-strength polynucleotide (PN) formulation at 6% for enhanced bio-stimulation compared with standard 2% Puri Eyes.
Specifically designed for the thin, delicate under-eye and periocular skin, optimising safety and efficacy in this area.
Stimulates fibroblast activity to boost collagen and elastin synthesis, improving dermal thickness and elasticity.
Reduces the appearance of fine lines, crow’s feet, under-eye wrinkles and early periocular ageing signs.
Helps diminish the look of dark circles and under-eye fatigue by improving skin density and tone.
Provides deep, long-lasting hydration through hyaluronic acid, improving skin texture and smoothness.
Supports wound-healing and tissue regeneration, accelerating recovery of stressed or damaged periocular skin.
Non-volumising, tissue-regenerative effect that maintains natural expression and contours around the eyes.
Intended for professional use with controlled micro-injection techniques, allowing precise, customised treatment patterns.
Animal-free regenerative approach using purified PN rather than classic animal-derived collagen.
Indications
Periocular / under-eye rejuvenation.
Fine lines and wrinkles around the eyes, including crow’s feet and infraorbital lines.
Dark circles and signs of tiredness under the eyes related to skin thinning and poor dermal quality.
Mild to moderate skin laxity and loss of elasticity in the under-eye and lateral canthal area.
Crepey, dehydrated or atrophic under-eye skin requiring regenerative support.
Patients seeking a regenerative biostimulator treatment rather than a volumising filler in the eye area.
Adjunctive treatment in comprehensive anti-ageing protocols for the periocular zone.
Composition
Sodium polynucleotide (PN) 6% (w/v), high-purity, low-molecular-weight fragments derived from purified salmon DNA (approx. 6 g per 100 mL; ~66 mg PN per 1.1 mL syringe).
Phosphate-buffered saline (PBS), pH ~7.0, q.s. to 1.1 mL.
Trace formulation excipients and stabilisers suitable for injectable PN solutions (exact proprietary composition not disclosed).
Formulation
Sterile, injectable, clear polynucleotide solution optimised for under-eye skin.
High-concentration sodium polynucleotide (6%) acting as a bio-stimulatory tissue-regeneration agent.
Buffered aqueous solution (phosphate-buffered saline) with physiological pH for improved tolerance.
Intended for intradermal / very superficial subdermal injection in the periocular area by trained professionals only.
Packaging
1.1 mL pre-filled sterile syringe.
1 syringe per box (single-patient, single-use).
Box labelled with product name (Puri Eyes / Puri Eyes Pro), batch number, manufacturing date and expiry date.
Supplied for professional use; needles or cannulas are typically supplied separately according to clinic preference.
Usage
Professional use only – restricted to licensed medical or aesthetic practitioners trained in periocular injection techniques.
Before treatment, assess the patient’s medical history, indications, contraindications and expectations; obtain informed consent.
Cleanse and disinfect the periocular area thoroughly following local aseptic protocol.
Recommended injection depth: very superficial dermal to superficial subdermal plane in the infraorbital and lateral canthal region, taking care to avoid intravascular injection.
Delivery devices and technique: commonly a 30–32G mesotherapy needle (e.g. 4–6 mm) with micro-depots or linear threading, or a 25–27G blunt microcannula placed in the subdermal plane according to the practitioner’s protocol.
Typical treatment protocol (example): 3–4 sessions spaced 2–3 weeks apart, using small aliquots per injection point to create a uniform grid or fanning pattern under and around the eyes.
The total volume per session is determined by the practitioner based on anatomy and indication; high-strength Pro formulation often requires lower volume per zone than standard-strength PN products.
After injection, gently mould or smooth the treated area if needed; avoid aggressive massage.
Post-treatment advice: avoid touching or applying make-up to the treated area for several hours; avoid saunas, intense exercise, alcohol and very hot or cold environments for 24 hours; follow clinic-specific aftercare and consider adjunctive cooling or PDRN/soothing patches if recommended.
Schedule maintenance courses according to clinical response – for example, one short course every 6–9 months or as indicated by skin condition and patient goals.
Dispose of used syringes and sharps immediately in approved clinical waste containers; do not reuse any remaining product.
Contraindications
Known hypersensitivity or allergy to polynucleotides, salmon-derived DNA, phosphate buffers or any component of the formulation.
Active skin infection, inflammation or dermatological disease at or near the injection site (e.g. herpes, bacterial infection, severe dermatitis).
Systemic infection, fever or acute illness at the time of the procedure.
History of severe keloid or hypertrophic scarring in the intended treatment area (use with caution or avoid).
Autoimmune disorders, immunosuppression or coagulation disorders where injectable biostimulators are contraindicated, unless managed under specialist supervision.
Pregnancy and breastfeeding (commonly treated as a precautionary contraindication in aesthetic practice).
Known history of severe allergic reactions or anaphylaxis to injectable aesthetic products.
Use in individuals below the legal age for cosmetic procedures in the practitioner’s jurisdiction.
Adverse Effects
Common, usually transient reactions at the injection site: redness (erythema), mild oedema, tenderness, warmth, itching, pinpoint bleeding or bruising.
Temporary papules or small nodules at injection points, typically resolving over several hours to a few days.
Less common: prolonged swelling or bruising, asymmetry, local inflammation or hyperpigmentation, particularly in patients prone to post-inflammatory pigmentation.
Rare but serious: infection, abscess formation, vascular compromise or embolic events if inadvertently injected intravascularly, or significant inflammatory/immune responses.
As with any periocular injection, improper technique or injection-plane errors may increase the risk of complications; emergency management protocols should be in place.
Storage Conditions
Store in a refrigerator at 2–8 °C unless otherwise specified on the packaging.
Do not freeze; freezing can damage the polynucleotide structure and compromise product performance.
Keep the syringe in its original blister and carton to protect from light and contamination until use.
Allow the product to reach near-room temperature before injection if recommended by the manufacturer, while maintaining aseptic handling.
Do not use after the expiry date printed on the packaging or if the solution appears cloudy, discoloured or contains particulates.
Single-use only; discard any unused solution after the procedure in accordance with local regulations for medical sharps and biological waste.
Duration
Initial protocols typically consist of 3\u20134 sessions at 2\u20133 week intervals, with results building progressively over 4\u20138 weeks after the last session. Maintenance treatment is usually recommended every 6\u201312 months, depending on the severity of periocular ageing, lifestyle factors and individual response.
Onset
Early improvements in hydration, radiance and fine lines are often observed within 3\u20137 days after treatment, with more pronounced changes in dermal density, wrinkle reduction and elasticity developing over 4\u20138 weeks as collagen and elastin synthesis increase. Because Puri Eyes Pro is higher strength, regenerative effects may be noticeable earlier or with fewer sessions compared to standard 2% PN formulations.
