Marketed as a professional Use injectable PN skin booster; no public evidence of MHRA licensed medicinal product status.
Distributed in the UK/EU aesthetics sector under cosmetic/medical Aesthetic frameworks; any device or regulatory markings (e.g. CE/UKCA) are detailed in the official brochure and pack labelling rather than in open wholesale listings.
Clinics are expected to use the product in accordance with local regulations governing injectable aesthetic treatments, patient consent and complication management.
Marketed as a professional Use injectable PN skin booster; no public evidence of MHRA licensed medicinal product status.
Distributed in the UK/EU aesthetics sector under cosmetic/medical Aesthetic frameworks; any device or regulatory markings (e.g. CE/UKCA) are detailed in the official brochure and pack labelling rather than in open wholesale listings.
Clinics are expected to use the product in accordance with local regulations governing injectable aesthetic treatments, patient consent and complication management.
Polynucleotide (PN) injectable skin booster
Description
iLLUMA Crystal Rose+ 5 x 5 ml is an advanced polynucleotide (PN) skin booster formulated to rejuvenate dry, ageing and photo-damaged skin. The injectable PN filler works at a cellular level to enhance skin tone and texture, restore luminosity and improve elasticity in the face, neck and décolleté. Each 5 ml vial contains a highly concentrated cocktail of 53 active ingredients, including polynucleotides, hyaluronic acid (20 mg/ml), peptides and glutathione. This combination supports fibroblast activation, stimulates collagen and elastin synthesis, improves dermal regeneration and provides antioxidant protection against free radicals. Supplied as a box of five 5 ml vials, iLLUMA Crystal Rose+ is intended for use by trained medical and aesthetic professionals as part of structured biorevitalisation/PN skin booster treatment protocols.
Bnefits
Deeply hydrates and rejuvenates dry, tired and dull skin by combining polynucleotides with hyaluronic acid (20 mg/ml).
Improves overall skin tone, texture and elasticity, helping to soften fine lines and visible signs of ageing.
Stimulates fibroblast activity and promotes new collagen and elastin production for firmer, more resilient skin.
Supports cellular regeneration and long-term skin health via polynucleotides and a multi-active complex of 53 ingredients.
Provides antioxidant protection and anti–free radical action through glutathione and other actives, helping to protect against environmental and oxidative stress.
Works at the cellular level as a PN filler/skin booster to restore a more youthful glow to targeted areas such as the face, neck and décolleté.
Highly concentrated bio-revitalisation ampoule suitable for combating age-related skin changes in professional treatment protocols.
Flexible treatment course with an initial series for regeneration followed by maintenance sessions every few months to sustain results.
Indications
Biorevitalisation of dry, dehydrated and ageing skin on the face, neck and décolleté.
Improvement of uneven skin tone, dullness and loss of radiance associated with age or environmental damage.
Enhancement of skin texture and elasticity where fine lines, superficial wrinkles and laxity have developed.
Support of dermal regeneration and fibroblast function in patients showing early to moderate signs of photoageing.
Adjunctive use with other professional aesthetic procedures (e.g. microneedling) where a PN skin booster is indicated, according to practitioner protocols.
Professional use only in aesthetic and dermatology clinics by appropriately trained injectors.
Composition
Polynucleotides (PN) – DNA-derived bio-revitalising fragments that support tissue repair, fibroblast activity and cellular regeneration.
Hyaluronic acid 20 mg/ml – hydrating glycosaminoglycan to improve skin moisture, plumpness and elasticity.
Glutathione – antioxidant tripeptide to help neutralise free radicals and support brightening and protection of the skin.
Peptides – bioactive peptides selected to enhance collagen and elastin synthesis and support dermal matrix integrity.
Total of 53 active ingredients (full INCI/ingredient list provided in the official iLLUMA Crystal Rose brochure/leaflet; detailed breakdown is not fully published by wholesalers).
Concentration: hyaluronic acid 20 mg/ml combined with polynucleotides, peptides, glutathione and additional active components.
Sterile solution supplied in 5 ml glass vials for intradermal/mesotherapy-style administration by professionals.
Polycomponent bio-revitalisation ampoule designed to act at cellular level to stimulate regeneration and collagen production.
Packaging
Box containing 5 x 5 ml glass vials of iLLUMA Crystal Rose+.
Each vial is individually sealed and labelled with product name, volume (5 ml) and batch information.
Outer carton branded as iLLUMA Crystal Rose+ with indication that it is a polynucleotide (PN) skin booster, for professional use only.
Some distributors also offer single 5 ml vials supplied individually outside of the full 5-vial box for clinic use.
Usage
For professional use only; treatment should be carried out by suitably trained medical or aesthetic practitioners in accordance with local regulations.
Assess the patient’s skin condition, medical history and contraindications before treatment; obtain informed consent and follow clinic protocols.
Cleanse and disinfect the treatment area (face, neck and/or décolleté) according to aseptic technique.
Administer iLLUMA Crystal Rose+ by appropriate injection technique (e.g. micro-papular/intradermal, nappage, mesotherapy-style injections or in combination with microneedling) as per the official protocol and practitioner training.
Initial treatment course: perform the first 3 sessions every 2–3 weeks to enhance cellular regenerative capacity and build dermal improvements.
Maintenance: after the initial course, perform additional top-up treatments every 3–6 months to maintain improved skin condition.
Adjust injected volume and distribution according to treatment area, skin quality and individual patient needs, not exceeding recommended dose per session.
After treatment, provide post-procedure care instructions (e.g. avoid makeup, saunas, sun exposure and vigorous exercise for a period as per clinic protocol; use high-SPF sun protection).
Dispose of used vials, needles and syringes as clinical sharps waste in line with local regulations.
Contraindications
Known hypersensitivity or allergy to any component of the formulation (e.g. hyaluronic acid, polynucleotides, peptides or glutathione).
Active skin infections, inflammatory dermatoses or open wounds at the intended treatment site.
History of severe keloid or hypertrophic scarring in the treatment area.
Autoimmune diseases, uncontrolled systemic illness or immunosuppression where injectable biorevitalisation is contraindicated, according to clinician judgment.
Pregnancy and breast-feeding, unless the practitioner determines otherwise in line with local guidance and available safety data (many aesthetic clinics list this as a precautionary contraindication).
Known bleeding disorders or patients on anticoagulant therapy where there is a high risk of bruising/bleeding, unless carefully assessed by a medical professional.
Any contraindications listed in the official iLLUMA Crystal Rose information leaflet or protocol documentation.
Adverse Effects
Expected injection-related reactions such as redness, swelling, mild pain, tenderness, itching or bruising at the injection sites, typically resolving within a few days.
Transient lumps or papules at injection points due to intradermal placement of the product, usually settling as the product disperses.
Rare risk of local infection, abscess formation or delayed inflammatory reactions if aseptic technique is not strictly followed.
Possible allergic or hypersensitivity reactions to one or more active substances or excipients.
Very rare but potential vascular complications (e.g. occlusion) associated with injectable facial treatments, requiring prompt recognition and management according to emergency protocols.
Post-inflammatory hyperpigmentation or temporary textural changes in susceptible individuals, particularly with aggressive needling or in darker skin types.
Storage Conditions
Store in a cool, dry place at controlled room temperature as specified in the product leaflet (typically between 2°C and 25°C, avoiding extremes of temperature).
Keep vials in their original outer carton to protect from light and contamination until use.
Do not freeze; protect from excessive heat, direct sunlight and sudden temperature changes.
Do not use after the expiry date printed on the packaging.
Once a vial has been opened, use immediately and do not store partially used vials; discard any unused product safely according to clinic waste protocols.
Duration
Typical protocol recommends an initial series of 3 treatments spaced every 2\u20133 weeks, followed by maintenance sessions every 3\u20136 months; overall treatment duration is ongoing, depending on patient response and maintenance schedule.
Onset
Hydration and improved radiance may be noticed within days to a couple of weeks after treatment; collagen stimulation and more pronounced improvements in tone, texture and elasticity develop gradually over several weeks following the initial course.
