Puri HiLo PN – Skinbooster

Puri

Injectable skin booster

Hyaluronic Acid + Polynucleotide (PN) combinational skin booster

CE Marked where required, complying with medical device / injectable product regulations in applicable markets.
Manufactured by WEDERM under standards for injectable aesthetic products.
Distributed through licensed aesthetic clinics and authorised wholesalers in compliance with regulatory and professional legal frameworks.

CE Marked where required, complying with medical device / injectable product regulations in applicable markets.
Manufactured by WEDERM under standards for injectable aesthetic products.
Distributed through licensed aesthetic clinics and authorised wholesalers in compliance with regulatory and professional legal frameworks.

Hyaluronic Acid + Polynucleotide (PN) combinational skin booster

Description

Puri HiLo PN is a dual-action skin booster combining medical-grade polynucleotides (PN) with hyaluronic acid (HA) in a 2.5 mL syringe, formulated to deeply hydrate, stimulate dermal regeneration and improve skin density, texture and elasticity. It targets facial, neck and hand skin, offering both immediate hydration and long-term dermal remodelling through fibroblast stimulation, collagen and elastin synthesis, and improved tissue regeneration.

Bnefits

Deep hydration via high- and low-molecular-weight hyaluronic acid, improving skin moisture and plumpness.
Polynucleotide-driven stimulation of fibroblast activity, collagen and elastin production for improved firmness and elasticity.
Dermal regeneration leading to smoother skin texture, reduced roughness and improved dermal density.
May improve pore appearance, uneven texture, pigmentation irregularities and overall skin tone.
Lifting and tightening effect due to increased dermal volume and structural support.
Supports skin repair and regeneration—particularly beneficial after damage from sun, environmental stress or aesthetic procedures.
Non-animal derived, medical-grade PN reduces risk of immunogenic reaction compared with animal collagen.
Long-lasting skin improvement when combined with recommended treatment protocol and maintenance sessions.

Indications

Facial skin rejuvenation – fine lines, loss of elasticity, dullness, uneven texture.
Neck and décolleté skin laxity and early signs of ageing.
Hand skin rejuvenation – thinning skin, loss of firmness, dehydration.
Skin needing both deep hydration and structural dermal support.
Post-procedure dermal recovery and maintenance (after laser, microneedling or other treatments), under clinician supervision.
Patients seeking anti-ageing, non-volumising skin boosters rather than filler-based volumisation.

Composition

Medical-grade polynucleotides (PN) – 25 mg per 2.5 mL syringe.
Hyaluronic acid (HA) – hybrid formulation (with high- and low-molecular-weight HA) for hydration and dermal support.
Phosphate-buffered saline (PBS) or isotonic buffer solution q.s. to 2.5 mL – physiological pH for biocompatibility.
Excipients and stabilisers typical for injectable HA/PN formulations (proprietary and not publicly detailed).

Formulation

Sterile injectable solution / gel combining HA and PN, ready for intradermal or superficial subdermal injection.
Hybrid HA + PN formulation purpose-built to provide immediate hydration and promote long-term dermal regeneration.
Designed for even tissue distribution when injected using mesotherapy or microbolus techniques.
Isotonic, pH-balanced, biocompatible injectable preparation suitable for face, neck and hands.

Packaging

1 × 2.5 mL pre-filled sterile syringe per box.
Single-use, sterile packaging — syringe inside protective blister or tray within outer carton labelled with batch, expiry date and handling instructions.
Needles or cannulas supplied separately according to practitioner preference and local regulations.

Usage

For professional use only by qualified aesthetic or medical practitioners.
Perform full skin assessment, medical history review and informed consent prior to treatment.
Cleanse and disinfect the treatment area thoroughly according to clinical protocol.
Injection depth: intradermal or superficial subdermal depending on area and indication.
Injection technique may include micro-bolus (micro-depot), nappage/mesotherapy, linear threading or fanning patterns as per practitioner’s protocol.
Typical initial treatment course: 3–4 sessions spaced 2–3 weeks apart, using 2.5 mL per session (or as clinically evaluated), covering face, neck, or hands as needed.
Post-injection care: avoid excessive heat, strong UV exposure, sauna, strenuous exercise for 24–48 hours; follow aftercare protocol including gentle moisturisation and sun protection.
Maintenance courses may be scheduled every 6–9 months depending on skin condition and ageing profile.
Dispose of used syringes and sharps according to clinical waste regulations; do not reuse.

Contraindications

Known hypersensitivity or allergy to polynucleotides, hyaluronic acid, formulation excipients or buffer components.
Active skin infection, inflammation, open wounds, dermatitis or eczema at injection site.
Systemic infection, fever or serious illness at the time of planned treatment.
Autoimmune disease, immunosuppression or coagulopathy when injectable treatments are contraindicated, unless under specialist supervision.
Pregnancy and breastfeeding — use only if deemed appropriate by treating practitioner and following local regulations.
History of severe allergic reactions to injectable aesthetic products.
Patients under the legal age for cosmetic injectable treatments in the practitioner’s jurisdiction.

Adverse Effects

Common injection-site reactions: redness, mild swelling, tenderness, itching, slight bruising or small papules, typically resolving within a few days.
Temporary lumps, bumps or unevenness if product placement is not uniform; usually self-resolving or manageable with gentle massage if advised.
Rare: prolonged swelling, hypersensitivity reactions, local inflammation or allergic reaction, particularly in predisposed individuals.
Risk of infection or vascular compromise if strict aseptic technique and anatomical knowledge are not adhered to.
As with any injectable procedure, risk of rare serious adverse events such as vascular occlusion, granuloma formation or tissue necrosis — though incidence is low with correct technique.

Storage Conditions

Store at refrigerated temperature (2–8 °C) until use, unless manufacturer indicates otherwise.
Do not freeze; avoid exposure to high temperatures or direct sunlight to preserve product integrity.
Keep in original sealed packaging until immediately before use to maintain sterility.
Use before expiry date; once opened, use single syringe per patient and discard leftover.
Dispose of used syringes and needles as clinical sharps waste according to regulations.

Duration

Initial course of 3\u20134 sessions over 6\u20139 weeks; visible improvements typically maintained for several months. Maintenance sessions every 6\u20139 months recommended to sustain results depending on patient factors and skin condition.

Onset

Hydration and skin softness are often noticeable within days after first session; improvements in skin texture, firmness, elasticity and dermal density typically emerge progressively over 4\u20138 weeks following full treatment course as collagen and elastin synthesis increases.