Nucleofill Hair Polynucleotide (Medium Plus)

Nucleofill

Hair booster injectable

Polynucleotide scalp mesotherapy / bio-restructuring gel

CE Marked medical device in the European market
Manufactured and controlled according to European medical device quality and safety standards
Professional Use Only injectable product distributed through regulated medical and aesthetic supply channels

CE Marked medical device in the European market
Manufactured and controlled according to European medical device quality and safety standards
Professional Use Only injectable product distributed through regulated medical and aesthetic supply channels

Polynucleotide scalp mesotherapy / bio-restructuring gel

Description

Nucleofill Hair Polynucleotide (Medium Plus) is an injectable polynucleotide gel specifically designed for scalp and hair revitalisation. Developed by Promoitalia Medical Aesthetics, it uses highly purified polymerised polynucleotides to nourish and biostructure the hair follicle environment, improve scalp microcirculation, and support hair regrowth. The treatment targets hair weakening and early hair loss, including androgenetic alopecia and postpartum thinning, and can also be used on the eyebrows and beard. Supplied as a sterile 2 ml pre-filled syringe, it is administered by intradermal/mesotherapy techniques in a series of sessions to reduce shedding, increase density and thickness, and improve overall scalp health.

Bnefits

Reduces hair loss and thinning by improving hair follicle trophism
Stimulates hair growth and increases hair density and thickness
Improves scalp microcirculation, oxygenation, and nutrient supply
Provides deep, long-lasting biostructuring of the scalp tissue
Enhances hair quality, strength, and overall vitality
Supports pre- and post-hair transplant protocols
Can be used for scalp, eyebrow, and beard revitalisation
Offers antioxidant protection via polymerised polynucleotides
Provides long-lasting results, typically maintained for around 6–12 months

Indications

Hair loss and hair weakening
Androgenetic alopecia (male and female pattern hair loss)
Incipient effluvium (early stages of excessive hair shedding)
Telogen effluvium and stress- or hormone-related shedding
Postpartum hair loss
Pre- and post-operative support for hair transplant procedures
Thinning of eyebrows
Beard thinning or patchy beard density
General scalp revitalisation and improvement of hair quality

Composition

Polymerised polynucleotides (sodium DNA), highly purified and of natural origin
Polynucleotide gel containing 20 mg of polynucleotides in 2 ml
Medium molecular weight polynucleotides (approximately 1,500 kDa)
Sterile, pyrogen-free injectable gel formulation

Formulation

Injectable polynucleotide bio-restructuring gel for scalp and hair
Often described as a 2% polynucleotide gel, supplied as 2 ml of product
Designed for intradermal / superficial mesotherapy administration to the scalp
High-viscosity gel with pH approximately 6.8–7.2 and viscosity around 35–43 Pa·s
Sodium DNA–based biostimulant targeting hair follicles and scalp tissue

Packaging

Box with 1 pre-filled syringe containing 2 ml of polynucleotide gel
Typically supplied with 2 sterile 30G x 12–13 mm needles
Includes instructions for use and treatment protocol guidance
Professional-use-only medical aesthetic presentation

Usage

For professional use only; administration should be performed by trained, medically qualified practitioners.
Indicated for superficial intradermal or mesotherapy injection into the scalp (and, where appropriate, eyebrows or beard).
Inject using micro-deposit / mesotherapy technique: small boluses (commonly around 0.05 ml per point) placed superficially in the scalp.
Standard protocol widely used: 4 treatment sessions – 2 sessions spaced 7 days apart, followed by 2 sessions spaced 14 days apart.
Alternative protocols may involve 3–4 sessions every 2–4 weeks, depending on clinical judgement and severity of hair loss.
Maintenance sessions are commonly recommended every 2–3 months or approximately every 6–12 months, according to patient response.
Before injection, cleanse and disinfect the scalp; avoid injecting into areas with active infection or inflammation.
Can be used alone or in combination protocols (e.g., alongside PRP or hair transplant procedures) following appropriate clinical guidance.
Do not exceed the total volume recommended per treatment area (typically up to 2 ml per session for the scalp).
Post-treatment: patients should avoid washing the scalp, intense physical exertion, and excessive sun or heat exposure for at least 24–48 hours, as per clinic protocol.

Contraindications

Known hypersensitivity or allergy to polynucleotides, sodium DNA, or any component of the product
Patients under 21 years of age
Pregnancy and breastfeeding
Active scalp infections or inflammatory skin conditions at the injection site
Current or past history of certain cancers as advised by the treating physician
Coagulation disorders or patients with impaired blood clotting
Active herpes infections in the treatment area
Severe systemic illnesses or uncontrolled autoimmune diseases
Any general contraindications to injectable mesotherapy procedures as assessed by a medical professional

Adverse Effects

Transient redness (erythema) at injection sites
Mild to moderate swelling or oedema at treated areas
Itchiness or pruritus of the scalp
Dryness or temporary discomfort of the scalp
Bruising or small haematomas at injection points
Localized tenderness or soreness after treatment
Rarely, allergic-type reactions (e.g., persistent itching, swelling) requiring medical evaluation
Very rarely, infection or nodules at injection sites if aseptic technique and aftercare are not strictly followed

Storage Conditions

Store at a controlled temperature, typically between 2°C and 25°C (some sources specify 2–8°C for the Nucleofill range); follow the instructions on the actual packaging.
Keep in a cool, dry place, protected from direct sunlight and moisture.
Do not freeze the product.
Store in the original box until use to protect from light and contamination.
Keep out of reach of children.
Use only within the expiry date printed on the packaging and do not use opened or damaged syringes.

Duration

Results are typically maintained for approximately 6\u201312 months, depending on individual physiology, lifestyle, severity of hair loss, and adherence to maintenance sessions.

Onset

Effects are gradual; improvements in hair shedding, density, and quality generally become noticeable over the course of the initial 3\u20134 treatment sessions and continue to evolve over subsequent months.