Nucleofill SOFT+ CE (EYES)

Nucleofill

Injectable periocular skin booster

Under-eye polynucleotide bio-stimulator

CE Marked medical device for use in the periocular area
Manufactured according to European medical device quality and safety standards for injectable biostimulating gels
Distributed through professional aesthetic and medical supply channels that comply with regional regulatory requirements
Intended for use only by qualified healthcare professionals in accordance with local regulations and manufacturer guidance

CE Marked medical device for use in the periocular area
Manufactured according to European medical device quality and safety standards for injectable biostimulating gels
Distributed through professional aesthetic and medical supply channels that comply with regional regulatory requirements
Intended for use only by qualified healthcare professionals in accordance with local regulations and manufacturer guidance

Under-eye polynucleotide bio-stimulator

Description

Nucleofill SOFT+ CE (EYES), also known as Nucleofill Eyes (Soft Plus), is a CE-marked polynucleotide-based injectable specifically developed for the delicate under-eye and periocular area. The product contains highly purified, low-molecular-weight sodium DNA (polynucleotides) in a sterile gel that deeply hydrates, brightens and biostimulates the thin skin around the eyes. By improving microcirculation, stimulating fibroblasts and enhancing collagen and elastin production, it targets dark circles, fine lines, crepey texture and under-eye puffiness. It is used by trained medical professionals as a regenerative alternative or complement to traditional tear trough fillers, providing natural-looking rejuvenation, improved skin quality and long-term tissue regeneration rather than volumisation alone.

Bnefits

Reduces the appearance of dark circles under the eyes
Softens fine lines and superficial wrinkles around the eyes
Improves under-eye puffiness and eye bags for a fresher look
Deeply hydrates and nourishes the thin periocular skin
Stimulates collagen and elastin synthesis for firmer, more elastic skin
Brightens and evens the tone of the under-eye area
Offers antioxidant protection and supports tissue regeneration
Improves skin texture, radiance and overall eye-area vitality
Provides a regenerative alternative or adjunct to tear trough filler
Suitable for sensitive, delicate skin around the eyes

Indications

Periocular and under-eye skin ageing
Dark circles and under-eye pigmentation caused by vascular and structural changes
Fine lines and superficial wrinkles around the eyes (crow’s feet, lower eyelid lines)
Mild to moderate under-eye bags and puffiness
Crepey, thin, dehydrated skin in the periocular area
Loss of firmness and elasticity around the eyes
Patients unsuitable or not ready for tear trough hyaluronic acid filler
Adjunctive treatment before or after blepharoplasty or lifting procedures (according to clinician judgement)
General biostimulation and quality improvement of the eye-contour skin

Composition

Polymerised polynucleotides (sodium DNA) of low molecular weight
Polynucleotide gel 40 mg in 2 ml (20 mg/ml) in many technical descriptions
Sodium DNA of natural origin with high purity
Excipients: Aqua (Water), Sodium Chloride, Sodium DNA as listed on several distributor ingredient summaries

Formulation

Sterile, low-viscosity sodium DNA-based polynucleotide gel for periocular injection
Low-molecular-weight polynucleotide chain fragments designed for rapid tissue penetration
Molecular weight approximately 50–100 kDa for the polynucleotide fragments, with product-level molecular weight specification around 1,500 kDa in some technical sheets
pH in the range of approximately 6.8–7.2
Viscosity reported around 35–43 Pa·s at specified shear conditions
Non-crosslinked bio-stimulating gel (not a volumising filler) aiming at tissue regeneration and hydration rather than structural filling

Packaging

Box containing 1 x 2 ml pre-filled sterile syringe of Nucleofill Soft Plus Eyes gel
Typically supplied with 2 sterile 30G x 12 mm (or similar) needles for injection
Single-use syringe intended for one patient only
Includes instructions for use and treatment guidance for healthcare professionals
CE-marked medical device packaging with batch number and expiry date clearly indicated

Usage

For professional use only; must be administered by appropriately trained and qualified medical practitioners familiar with periocular injections.
Designed for superficial intradermal / micro-wheal (micro-bleb) technique in the periocular region, including lower eyelid, tear trough area, crow’s feet and upper eyelid margin where clinically appropriate.
A commonly referenced technique uses micro-deposits of approximately 0.05 ml per wheal, spaced about 0.5 cm apart, placed very superficially in the skin.
Standard treatment protocols generally recommend 2–3 initial sessions spaced about 2–4 weeks apart, depending on the clinic’s protocol and patient needs.
Some protocols suggest an initial course of 3 sessions, followed by maintenance treatments every 3–6 months to sustain results.
The injection should avoid intravascular administration; aspirate according to clinic protocol and inject slowly with careful anatomical awareness of vessels and orbital structures.
Do not inject into areas with active infection, severe inflammation, or compromised skin barrier; postpone treatment until resolved.
Before treatment, thoroughly cleanse and disinfect the skin around the eyes and remove all cosmetics.
Post-treatment recommendations often include avoiding makeup, rubbing the treated area, intense exercise, saunas, swimming and excessive sun or heat exposure for at least 24 hours, following clinic instructions.
The total injected volume per session is typically the contents of one 2 ml syringe for both eyes, adjusted by the practitioner according to indications and patient anatomy.
Can be combined, under clinician guidance, with other procedures such as botulinum toxin, peels, laser, or surgery in tailored treatment plans, with appropriate spacing between procedures.

Contraindications

Known hypersensitivity or allergy to polynucleotides (sodium DNA) or any component of the product
Pregnancy and breastfeeding (as a precaution, pending sufficient safety data)
Patients under the age specified by local regulations and clinic policy (commonly under 18 years)
Active skin infections, inflammation or dermatological diseases in the intended treatment area (e.g., dermatitis, eczema, bacterial or viral infections including active herpes simplex)
History of severe allergic reactions or anaphylaxis to injectable products with similar excipients
Uncontrolled systemic diseases, significant autoimmune or connective tissue disorders, unless cleared by the treating physician
Coagulation disorders, use of anticoagulant therapy or conditions that significantly increase bleeding risk, unless carefully assessed and managed by a physician
History of keloid or hypertrophic scarring in the periorbital area or other factors that would contraindicate injectable biostimulators by clinical judgement
Any general contraindication to aesthetic injectable procedures as determined by a qualified healthcare professional

Adverse Effects

Transient redness (erythema) at the injection sites around the eyes
Mild to moderate swelling or oedema in the treated periocular area, usually resolving within a few days
Minor bruising or small haematomas at injection points, particularly in patients prone to bruising
Local tenderness, discomfort or tight sensation following treatment
Temporary itching, dryness or mild irritation in the treated skin
In rare cases, delayed hypersensitivity or inflammatory reactions, which may require medical assessment and management
Very rare risk of infection at injection sites if aseptic technique or aftercare is inadequate
As with any periocular injection, inadvertent intravascular injection or injury to local structures is a theoretical risk and emphasises the need for skilled administration

Storage Conditions

Store in a clean, dry place at a controlled temperature, commonly indicated as between 2°C and 25°C (follow the exact storage range on the packaging).
Protect from direct sunlight and excessive heat or cold.
Do not freeze the product.
Keep in the original outer carton until use to protect from light and contamination.
Do not use after the expiry date printed on the packaging.
Single-use device: do not resterilise or reuse a previously opened syringe.
Keep out of reach of children.

Duration

Clinical protocols and user reports commonly indicate that, after an initial course of 2\u20133 sessions, results such as improved hydration, brightness and fine-line reduction can be maintained for several months, with many practitioners recommending maintenance sessions every 3\u20136 months and overall effect duration in the range of approximately 6\u201312 months depending on individual factors.

Onset

Patients often notice an improvement in hydration, smoothness and brightness in the under-eye area within days to a few weeks after the first session, with more pronounced and lasting results typically developing progressively over the full course of 2\u20133 treatments and ongoing collagen and elastin remodelling over subsequent weeks.