Nucleofill 25

Nucleofill

Aesthetic Medicine

Injectable polynucleotide biostimulant / skin booster

Class III CE Marked medical device for aesthetic intradermal use in the EU/EEA market (as indicated by distributors describing Nucleofill 25 Strong as a CE Marked device).
Manufactured under quality systems compliant with ISO 13485 for medical devices (per typical Promoitalia Medical Aesthetics documentation and regulatory status).
Distributed in accordance with applicable EU Medical Device Regulation (MDR) / legacy Medical Device Directive (MDD) and local country regulations via authorised channels.

Class III CE Marked medical device for aesthetic intradermal use in the EU/EEA market (as indicated by distributors describing Nucleofill 25 Strong as a CE Marked device).
Manufactured under quality systems compliant with ISO 13485 for medical devices (per typical Promoitalia Medical Aesthetics documentation and regulatory status).
Distributed in accordance with applicable EU Medical Device Regulation (MDR) / legacy Medical Device Directive (MDD) and local country regulations via authorised channels.

Injectable polynucleotide biostimulant / skin booster

Description

Nucleofill 25 (also marketed as Nucleofill Strong or Nucleofill 25 Strong) is a high-viscosity injectable biostimulant gel based on natural polymerised polynucleotides at a concentration of 25 mg/ml. It is designed for deep skin renewal and bio-restructuring, targeting advanced signs of ageing, moderate to deep wrinkles, loss of elasticity and dehydration. By delivering highly purified long-chain polynucleotides, Nucleofill 25 activates fibroblasts, stimulates type I collagen and elastin synthesis, provides strong antioxidant protection and improves tissue oxygenation and hydration. The product is supplied as a sterile, single-use 1.5 ml pre-filled syringe (needle not included) for professional mesotherapy / biorevitalisation treatments of the face, neck, décolleté, hands and selected body areas with scars or stretch marks.

Bnefits

Stimulates fibroblasts and promotes collagen and elastin production, improving skin density, firmness and elasticity.
Provides intensive bio-restructuring of mature, photo-damaged and oxygen-deprived skin.
Deeply hydrates the skin by increasing water binding capacity and improving extracellular matrix quality.
Improves the appearance of moderate to deep facial wrinkles while preserving natural facial expression.
Helps reduce the visibility of scars and stretch marks through tissue regeneration and remodelling.
Delivers strong antioxidant and free-radical scavenging activity, reducing oxidative stress and preventing premature ageing.
Lifting and tightening effect with more defined contours and improved skin tone.
Suitable for all skin types, including dehydrated and environmentally damaged skin.
No hyaluronic acid – based purely on highly purified polynucleotides.
Provides long-lasting results when used in a course of treatments with relatively short recovery time.

Indications

Mature, photo-aged or chronically dehydrated skin requiring deep regeneration and bio-restructuring.
Moderate to deep facial wrinkles and folds (e.g. cheeks, nasolabial areas, lower face).
Loss of skin firmness, elasticity and facial contour definition.
Dull, tired-looking or oxygen-deprived skin with reduced radiance.